Abstract: The FNIII13 domain of fibronectin and smaller fragments thereof have a tumour cell proliferation inhibitory effect. Compositions are provided comprising fragments of fibronectin having the FNIII 13 domain and fragments thereof. A system comprising cells exposed to fibronectin and caused to proliferate by the presence of tenascin are used as an in vitro method for screening possible anti-tumour agents. Cell-free systems comprising a fibronectin ligand and tenascin are also employed for screening potential anti-tumour or anti-cancer agents. Test compounds are assayed for the ability to disrupt binding of the fibronectin ligand to tenascin. A further cell-free system additionally includes a syndecan molecule.
Type:
Grant
Filed:
September 18, 2006
Date of Patent:
September 13, 2011
Assignee:
Novartis Forschungesstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Abstract: The present invention relates to the phosphorylated form of nuclear serine/threonine protein kinase, designated nuclear, Dbf2-related kinase (Ndr), and provides assays and materials for identifying modulators thereof. The invention relates to the fields of molecular biology, chemistry, pharmacology, and screening technology.
Type:
Grant
Filed:
November 25, 2003
Date of Patent:
August 30, 2011
Assignee:
Novartis Forschungesstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Inventors:
Samuel Joseph Bichsel, Brian Arthur Hemmings, Mario Reinhard Stegert, Rastislav Tamaskovic