Abstract: Methods for building an atomic model of a protein molecule that include: (a) identifying a protein molecule with at least 20% sequence identity to Microsomal Prostaglandin E Synthase 1 (MPGES1) and (b) utilizing the atomic coordinates of MPGES1 to obtain an atomic model of the identified protein molecule are provided. Methods for determining a drug candidate compound that interacts with members of the MAPEG family, in particular MPGES1, are also provided.
Type:
Application
Filed:
January 23, 2009
Publication date:
August 25, 2011
Applicant:
NOVASAID AB
Inventors:
Hans Hebert, Caroline Jegerschold, Per-Johan Jakobsson, Ralf Morgenstern
Abstract: A compound of formula (1) as well as pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compound. The compound is useful for the treatment of disorder from pain, fever, inflammation and cancer.
Type:
Application
Filed:
February 19, 2009
Publication date:
December 23, 2010
Applicant:
Novasaid AB
Inventors:
Johan Wannberg, Mathias Alterman, Patric Stenberg, Jacob Westman