Patents Assigned to Novazyme Pharmaceuticals, Inc.
  • Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester ?-N-acetyl glucosimanidase
    Patent number: 7135322
    Abstract: The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiester?N-acetyl glucosimanidase (phosphodiester ?-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal bydrolases having an N-acetylglucosamine-1-phosphate.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: November 14, 2006
    Assignee: Novazyme Pharmaceuticals, Inc.
    Inventors: William Canfield, Stuart Kornfeld
  • Phosphodiester alpha-GlcNAcase of the lysosomal targeting pathway
    Publication number: 20030148460
    Abstract: The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme phosphodiester &agr;-GlcNAcase, methods of producing and methods of purifying this enzyme.
    Type: Application
    Filed: November 29, 2002
    Publication date: August 7, 2003
    Applicant: NOVAZYME PHARMACEUTICALS, INC.
    Inventor: William M. Canfield
  • Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester alpha-N-acetyl glucosimanidase
    Publication number: 20030143669
    Abstract: The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiester &agr; N-acetyl glucosimanidase (phosphodiester &agr;-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal hydrolases having an N-acetylglucosamine-1-phosphate.
    Type: Application
    Filed: December 21, 2001
    Publication date: July 31, 2003
    Applicant: NOVAZYME PHARMACEUTICALS, INC.
    Inventors: William Canfield, Stuart Kornfeld
  • Highly phosphorylated acid beta-glucocerebrosidase and methods of treating gaucher's disease
    Publication number: 20030133924
    Abstract: The present invention provides a highly phosphorylated acid beta-glucocerebrosidase (GBA), which can be employed in an enzyme replacement therapy protocol to treat patients suffering from Gaucher's disease.
    Type: Application
    Filed: December 21, 2001
    Publication date: July 17, 2003
    Applicant: NOVAZYME PHARMACEUTICALS, INC.
    Inventor: William Canfield
  • Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells
    Publication number: 20030124652
    Abstract: The present invention provides a method for producing high mannose glycoproteins in complex carbohydrate deficient cells and the glycoproteins obtained therein.
    Type: Application
    Filed: December 21, 2001
    Publication date: July 3, 2003
    Applicant: NOVAZYME PHARMACEUTICALS, INC.
    Inventor: William M. Canfield
  • Method of producing glycoproteins having reduced complex carbohydrates in mammalian cells
    Publication number: 20030124653
    Abstract: The present invention provides a method of producing glycoproteins having reduced complex carbohydrates in a mammalian cell, glycoproteins produced by the method and cells that produce the glycoproteins.
    Type: Application
    Filed: December 21, 2001
    Publication date: July 3, 2003
    Applicant: NOVAZYME PHARMACEUTICALS, INC.
    Inventor: William M. Canfield
  • Soluble GlcNAc phosphotransferase
    Publication number: 20030119088
    Abstract: The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same.
    Type: Application
    Filed: December 21, 2001
    Publication date: June 26, 2003
    Applicant: NOVAZYME PHARMACEUTICALS, INC.
    Inventors: William Canfield, Mariko Kudo
  • Methods for producing highly phosphorylated lysosomal hydrolases
    Publication number: 20020150981
    Abstract: The present invention provides highly phosphorylated lysosomal hydrolases, methods of modifying lysosomal hydrolases with the lysosomal targeting pathway enzymes GlcNAc-phosphotransferase and/or phosphodiester &agr;-GlcNAcase.
    Type: Application
    Filed: November 9, 2001
    Publication date: October 17, 2002
    Applicant: NOVAZYME PHARMACEUTICALS, INC.
    Inventor: William M. Canfield
  • Methods for producing highly phosphorylated lysosomal hydrolases
    Publication number: 20020025550
    Abstract: The present invention provides highly phosphorylated lysosomal hydrolases, methods of modifying lysosomal hydrolases with the lysosomal targeting pathway enzymes GlcNAc-phosphotransferase and/or phosphodiester 60 -GlcNAcase.
    Type: Application
    Filed: July 2, 2001
    Publication date: February 28, 2002
    Applicant: NOVAZYME PHARMACEUTICALS, INC.
    Inventor: William M. Canfield