Abstract: A novel co-crystal of N?-(7-fluoropyrrolo[1,2a]quinoxalin-4-yl)pyrazine-2-carbohydrazide with oxalic acid is disclosed. The disclosed oxalic acid co-crystal demonstrates cancer cell growth inhibition and is more bioavailable than the corresponding free base when administered as a suspension.
Type:
Grant
Filed:
April 8, 2009
Date of Patent:
November 15, 2011
Assignee:
Novelix Pharmaceuticals, Inc.
Inventors:
Victor J Bauer, Mike H O'Neill, Barbara J Kidon, Burkhard Jansen
Abstract: A method of treating inflammation and hyperkeratotic lesions in a mammal in need thereof, by administering the following compound (NVX-207), a related compound, or a pharmaceutically acceptable salt thereof to the mammal.
Abstract: A novel co-crystal of N?-(7-fluoropyrrolo[1,2a]quinoxalin-4-yl)pyrazine-2-carbohydrazide with oxalic acid is disclosed. The disclosed oxalic acid co-crystal demonstrates cancer cell growth inhibition and is more bioavailable than the corresponding free base when administered as a suspension.
Type:
Application
Filed:
April 8, 2009
Publication date:
February 10, 2011
Applicant:
NOVELIX PHARMACEUTICALS, INC.
Inventors:
Victor J. Bauer, Mike H. O'Neill, Barbara J. Kidon, Burkhard Jansen
Abstract: The present invention relates to novel betulinic acid derivatives with increased activity for the treatment of carcinomas and HIV diseases, a method for preparing such novel betulinic acid derivatives as well as their use as pharmaceuticals.
Type:
Grant
Filed:
December 21, 2007
Date of Patent:
December 14, 2010
Assignee:
Novelix Pharmaceuticals, Inc.
Inventors:
Edgar Selzer, Burkhard Jansen, Reinhard Paschke
Abstract: The present invention relates to novel betulinic acid derivatives with increased activity for the treatment of carcinomas and HIV diseases, a method for preparing such novel betulinic acid derivatives as well as their use as pharmaceuticals.
Type:
Application
Filed:
December 21, 2007
Publication date:
September 4, 2008
Applicant:
Novelix Pharmaceuticals, Inc.
Inventors:
Edgar Selzer, Burkhard Jansen, Reinhard Paschke
Abstract: The present invention relates to novel betulinic acid derivatives with increased activity for the treatment of carcinomas and HIV diseases, a method for preparing such novel betulinic acid derivatives as well as their use as pharmaceuticals.
Type:
Grant
Filed:
February 11, 2004
Date of Patent:
December 25, 2007
Assignee:
Novelix Pharmaceuticals, Inc.
Inventors:
Edgar Selzer, Burkhard Jansen, Reinhard Paschke
Abstract: The present invention relates to novel betulinic acid derivatives with increased activity for the treatment of carcinomas and HIV diseases, a method for preparing such novel betulinic acid derivatives as well as their use as pharmaceuticals.
Type:
Application
Filed:
February 11, 2004
Publication date:
August 31, 2006
Applicant:
Novelix Pharmaceuticals, Inc.
Inventors:
Edgar Selzer, Burkhard Jansen, Reinhard Paschke