Abstract: A method and device for selective in vivo ablation of fresh blood thrombi by means of non-invasive focused high power acoustic energy. The method comprises applying a plurality of pulses of high energy acoustic waves or a continuous acoustic wave, focused at the location of a thrombus in a blood vessel, resulting in the ablation of the thrombus, and restoration of blood flow. There is also provided a device for the controlled generation and application of focused pulsed, or continuous, acoustic energy waves of predetermined energy and frequency.