Patents Assigned to Novexel
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Patent number: 8148366Abstract: The invention relates to nitrogenous heterocyclic compounds of formula (I): in which: R1 represents hydrogen, —(CH2)m—NH2, —(CH2)m—NH(C1-C6)alk, —(CH2)m—N(C1-C6)alk2, —(CH2)m—NH—C(NH)NH2 or —(CH2)m—NH—CH?NH, m is equal to 1 or 2; R2 and R3 together form a nitrogenous heterocycle of aromatic character with 5 vertices containing 1, 2 or 3 nitrogen atoms, substituted on a nitrogen atom by R4; R4 represents hydrogen, C1-C6)alk or a chain of formula: -(A)n-(NH)o—(CH2)p—(CHR?)qR? A represents C?O, C?NH or SO2; R? represents hydrogen or carboxy.Type: GrantFiled: August 5, 2009Date of Patent: April 3, 2012Assignee: Novexel SAInventors: Benoit Ledoussal, Marie-Edith Gourdel, Emilie Renaud, Camille Pierres, Adel Kebsi
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Nitrogenous heterocyclic compounds, preparation thereof and use thereof as antibacterial medicaments
Patent number: 8063219Abstract: The invention concerns nitrogenated heterocyclic compounds, their preparation and use as antibacterial drugs, compounds of general formula (I) wherein R1 represents a (CH2)n-NHR2 or (CH2)n-NHR radical, where R is a (C1-C6) alkyl and n is equal to 1 or 2; R2 represents a hydrogen atom; R3 and R4 together form an aromatic nitrogenated heterocycle with 5 apexes with 1, 2 or 3 nitrogen atoms optionally substituted by one or several R? groups, R? being selected in the group composed of a hydrogen atom and alkyl radicals with 1 to 6 carbon atoms; in free form, as zwitterions, and in the form of salts of pharmaceutically acceptable inorganic or organic bases and acids.Type: GrantFiled: April 11, 2008Date of Patent: November 22, 2011Assignee: NovexelInventors: Maxime Lampilas, David Alun Rowlands, Adel Kebsi, Benoit Ledoussal, Camille Pierres -
Publication number: 20110046102Abstract: The invention concerns the compounds meeting formula (I: wherein one of R1 and R2 is a hydrogen and the other a fluorine or both represent a fluorine, in free form, in the form of zwitterions and of salts with pharmaceutically acceptable mineral or organic bases, the preparation thereof and their use as medicinal products inhibiting the action of ?-lactamases by pathogenic bacteria.Type: ApplicationFiled: April 24, 2009Publication date: February 24, 2011Applicant: NovexelInventors: Benoit Ledoussal, Marie-Edith Gourdel
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Publication number: 20100197928Abstract: The disclosure relates to a method for preparing a compound of formula (I), wherein P1 and P2 are groups protecting the carboxylic acid and oxyamine functions, starting from pyroglutamic acid (S). The disclosure also relates to novel intermediates.Type: ApplicationFiled: September 12, 2008Publication date: August 5, 2010Applicant: NOVEXELInventors: Alain Priour, Alain Bonnet, Gilles Oddon, Alain Mazurie
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Publication number: 20100092443Abstract: The invention relates to the combination of nitrogenated heterocyclic antibacterial compounds of formula (I) with other antibacterial compounds and the use of same as drugs. The nitrogenated heterocyclic compounds are of general formula (I) wherein R1 represents a (CH2)n-NH2 or (CH2)n—NHR radical, where R is a (C1-C6) alkyl and n is equal to 1 or 2; R2 represents a hydrogen atom; R3 and R4 together form an aromatic nitrogenated heterocycle with 5 apexes with 1, 2 or 3 nitrogen atoms optionally substituted by one or several R? groups, R? being selected in the group composed of a hydrogen atom and the alkyl radicals with 1 to 6 carbon atoms, in free form, as zwitterions, and in the form of salts of pharmaceutically acceptable inorganic or organic bases and acids.Type: ApplicationFiled: August 5, 2009Publication date: April 15, 2010Applicant: NovexelInventors: Premavathy Levasseur, John Lee Pace, Kenneth Coleman, John Lowther
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Publication number: 20100093784Abstract: The invention relates to nitrogenous heterocyclic compounds of formula in which: R1 represents hydrogen, —(CH2)m—NH2, —(CH2)m—NH(C1-C6)alk, —(CH2)m—N(C1-C6)alk2, —(CH2)m—NH—C(NH)NH2 or —(CH2)m—NH—CH?NH, m is equal to 1 or 2; R2 and R3 together form a nitrogenous heterocycle of aromatic character with 5 vertices containing 1, 2 or 3 nitrogen atoms, substituted on a nitrogen atom by R4; R4 represents hydrogen, C1-C6)alk or a chain of formula: -(A)n-(NH)o—(CH2)p—(CHR?)qR? A represents C?O, C?NH or SO2; R? represents hydrogen or carboxy.Type: ApplicationFiled: August 5, 2009Publication date: April 15, 2010Applicant: NovexelInventors: Benoit Ledoussal, Marie-Edith Gourdel, Emilie Renaud, Camille Pierres, Adel Kebsi
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Publication number: 20100087648Abstract: The invention relates to nitrogen-containing heterocyclic compounds of general formula (I) wherein: R1 represents a (CH2)n—NH2 radical, n being equal to 1 or 2; R2 represents a hydrogen atom; R3 and R4 form together a nitrogen-containing heterocycle with aromaticity with 5 apices containing 1, 2 or 3 nitrogen atoms, substituted on this nitrogen atom or one of these nitrogen atoms with a (CH2)m—(C(O))p—R5 group, m being equal to 0, 1, 2 or 3, p being equal to 0 or 1 and R5 representing a hydroxy group, in which case p is equal to 1, or an amino, (C1-C6)alkyl or di-(C1-C6)alkyl amino, a nitrogen-containing heterocycle with aromaticity with 5 or 6 apices containing 1 or 2 nitrogen atoms and if necessary, an oxygen or sulfur atom; it being understood that when the sub-group (C(O))p—R5 forms a carboxy, amino, (C1-C6) alkyl or di-(C1-C6) alkyl amino, group, m is different from 0 or 1; in free form or as zwitterions and salts with pharmaceutically acceptable mineral or organic bases and acids, to their preparaType: ApplicationFiled: August 5, 2009Publication date: April 8, 2010Applicant: NovexelInventors: Maxime Lampilas, David Rowlands, Benoit Ledoussal, Marie-Edith Gourdel, Emilie Renaud, Camille Pierres, Adel Kebsi
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Publication number: 20100048528Abstract: This invention discloses and claims methods for inhibiting bacterial ?-lactamases and treating bacterial infections by inhibiting bacterial ?-lactamases in man or an animal comprising administering a therapeutically effective amount to said man or said animal of a compound, or pharmaceutically acceptable salt thereof, of formula (I) either alone or in combination with a ?-lactamine antibiotic wherein said combination can be administered separately, together or spaced out over time. Pharmaceutical compositions comprising a compound of formula (I), or a combination of a compound of formula (I) and a therapeutically effective amount of a ?-lactamine antibiotic, and a pharmaceutically acceptable carrier are also disclosed and claimed.Type: ApplicationFiled: November 2, 2009Publication date: February 25, 2010Applicant: NovexelInventors: Jozsef Aszodi, Claude Fromentin, Maxime Lampilas, David Alan Rowlands
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Patent number: 7612087Abstract: This invention discloses and claims methods for inhibiting bacterial ?-lactamases and treating bacterial infections by inhibiting bacterial ?-lactamases in man or an animal comprising administering a therapeutically effective amount to said man or said animal of a compound, or pharmaceutically acceptable salt thereof, of formula (I) either alone or in combination with a ?-lactamine antibiotic wherein said combination can be administered separately, together or spaced out over time. Pharmaceutical compositions comprising a compound of formula (I), or a combination of a compound of formula (I) and a therapeutically effective amount of a ?-lactamine antibiotic, and a pharmaceutically acceptable carrier are also disclosed and claimed.Type: GrantFiled: July 26, 2004Date of Patent: November 3, 2009Assignee: NovexelInventors: Jozsef Aszodi, Claude Fromentin, Maxime Lampilas, David Alan Rowlands
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Publication number: 20090018329Abstract: The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a method for preparing these compounds, and to their use as medicaments, in particular as antibacterials and ?-lactamase inhibitors.Type: ApplicationFiled: September 16, 2008Publication date: January 15, 2009Applicant: NovexelInventors: Maxime Lampilas, Branislav Musicki, Michel Klich, David Allen Rowlands
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Patent number: 7439253Abstract: The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a method for preparing these compounds, and to their use as medicaments, in particular as antibacterials and ?-lactamase inhibitors.Type: GrantFiled: December 4, 2003Date of Patent: October 21, 2008Assignee: NovexelInventors: Maxime Lampilas, Branislav Musicki, Michel Klich, David Alan Rowlands
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Patent number: 7232833Abstract: The invention relates to 4-substituted quinoline compounds of general formula: which are active as antimicrobials, in which: X1, X2, X3, X4 and X5 is C—R?1, to C—R?5 respectively, or alternatively at most one represents N, Y represents CHR, CO, CROH, CRNH2, CRF or CF2, R being a hydrogen or alkyl, m is 1, 2 or 3 and n is 0, 1 or 2, Z is CH2 or Z is O, S, SO, SO2 and, in this case, n is equal to 2, R2 is —CO2R, —CH2CO2R, —CH2—CH2CO2R, —CH2OH or —CH2—CH2OH, wherein R is as defined above, R3 represents phenyl, heteroaryl or alk-Ro3, where alk is alkyl and Ro3 represents various groups, where appropriate containing oxygen, sulfur or amine, in their enantiomeric or diastereoisomeric forms or their mixtures, and/or where appropriate in the syn or anti form or their mixtures, and their salts.Type: GrantFiled: March 26, 2004Date of Patent: June 19, 2007Assignee: NovexelInventors: Antony Bigot, Youssef El-Ahmad, Jean-Luc Malleron, Jean-Paul Martin, Serge Mignani, Guy Pantel, Baptiste Ronan, Michel Tabart, Michel Cheve, Fabrice Viviani
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Patent number: 7232834Abstract: Quinolylpropylpiperidine derivatives of general formula (I) in which R1 is hydrogen or fluorine, R2 is carboxyl, carboxymethyl or hydroxymethyl, R3 is alkyl substituted either with phenylthio optionally substituted with halogen, hydroxyl, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkyloxycarbonyl, cyano or amino, or with cycloalkylthio (3 to 7 members) optionally substituted with halogen or trifluoromethyl, or with heteroarylthio (5 to 6 members and 1 to 4 heteroatoms chosen from N, O and S), optionally substituted with halogen, hydroxyl, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkyloxycarbonyl, cyano or amino or R3 is propargyl substituted by phenyl or heteroaryl as defined above and R4 is alkyl, alkenyl-CH2— or alkynyl-CH2—, cycloalkyl or cycloalkylalkyl, in their various isomeric forms, separate or as mixtures, and also their salts, their preparation process and intermediates and the compositions containing them.Type: GrantFiled: September 10, 2003Date of Patent: June 19, 2007Assignee: Novexel SAInventors: Eric Bacque, Antony Bigot, Youssef El Ahmad, Jean-Luc Malleron, Serge Mignani, Baptiste Ronan, Michel Tabart, Fabrice Viviani