Patents Assigned to Novo Nordisk A/S
  • Publication number: 20190275259
    Abstract: A method of manufacturing a pen drug delivery device comprising the steps of (i) providing a drug delivery device comprising a dose indicator member adapted to move relative to a housing during dose setting and dose expelling corresponding to an axis of rotation, the indicator member having an initial position corresponding to no dose amount being set, (ii) arranging the indicator member in the initial rotational position, and (iii) providing on the housing and on the indicator member respectively a pair of zero markers having a predetermined rotational offset. By this arrangement the issue of finding the correct initial (zero) rotational position of the indicator member is addressed by providing corresponding and rotationally paired zero markings on the pen housing and the indicator member after the pen device has been assembled, this allowing the “true” initial position to be detected by image capture and subsequent image analysis.
    Type: Application
    Filed: May 29, 2017
    Publication date: September 12, 2019
    Applicant: Novo Nordisk A/S
    Inventors: Bennie Peder Smiszek Pedersen, Thomas Rosengaard Poulsen
  • Patent number: 10406298
    Abstract: The present invention provides an injection needle unit (10) comprising: a needle assembly (20) comprising: an injection needle (25) extending along a longitudinal axis and having a distal needle end configured for insertion into a subject and a proximal needle end configured for penetration of a reservoir septum, and a skirt (22) surrounding the proximal needle end and defining a receiving space (28) for reception of a needle mount of a drug delivery device, the skirt (22) comprising a slot (24), and a block structure (32) supported exteriorly of the skirt (22), wherein the block structure (32) is biased towards the longitudinal axis and is capable of radial displacement through the slot (24) from a latched position outside the receiving space (28) to a released position within the receiving space (28).
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: September 10, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Henrik Bengtsson, Emil Gram Spork, Lars Eilertsen
  • Patent number: 10406291
    Abstract: An autoinjector (100) for expelling a single dose of drug from a drug cartridge (600) including a piston (630), the autoinjector including: a base (200, 220), a needle (500) that is fixedly mounted relative to the base (200, 220), a plunger (310, 320, 400) adapted for cooperation with the piston (630), an actuating spring (330) provided as a helical compression spring arranged to act on the plunger (310, 320, 400) by exerting an axial force on the plunger to drive the piston (630) distally, and a needle shield (350, 380) axially movable relative to the base (200, 220) between an extended position and a collapsed position. The autoinjector defines a lock (320, 328, 380, 388) that is released when the needle shield (350, 380) is moved from the extended position to the collapsed position.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: September 10, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Soeren Kjellerup Hansen, Mads Schenstroem Stefansen, Matias Melander, Bastian Gaardsvig Kjeldsen
  • Patent number: 10398782
    Abstract: The invention relates to MIC-1 compounds. More specifically it relates to compounds comprising a MIC-1 polypeptide with an N-terminal amino acid extension and a protractor wherein the amino acid extension comprises 3 to 36 amino acid residues and where the MIC-1 polypeptide and the N-terminal amino acid extension together have a calculated pI lower than 6.5. The compounds of the invention have MIC-1 activity. The invention also relates to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable excipients, as well as the medical use of the compounds.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: September 3, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Xiang Gao, Xujia Zhang, Hongtao Guan, Henning Thoegersen, Kristian Sass-Oerum, Lars Fogh Iversen, Per Noergaard, Sebastian Beck Joergensen, Kristian Tage Hansen, Yi Wang, Kilian Waldemar Conde Frieboes, Birgit Wieczorek
  • Patent number: 10392428
    Abstract: The invention relates to a derivative of a GLP-1 analog of a general Formula I, which derivative comprises a side chain attached to a Lys residue at position 34, 35, 36, 37, 38, or 39 of the GLP-1 analog. The side chain comprises a Branched linker, a 1st and a 2nd Protractor and a Pre-linker. The Branched linker is connected to the Lys residue of the GLP-1 analog via the Pre-linker and to the 1st and the 2nd Protractor via a 1st and 2nd Post-linker, respectively. The Branched linker may, e.g., be a tri-radical of Lys. The 1st and the 2nd Protractor is C20 diacid. Various linker elements may be used in the Prelinker as well as the two Post-linkers. The invention also relates to novel GLP-analogs, novel side chain intermediates and their manufacture and use to prepare derivatives of biologically active peptides and proteins, as well as pharmaceutical compositions and medical uses of the analogs and derivatives.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: August 27, 2019
    Assignee: Novo Nordisk A/S
    Inventor: Jacob Kofoed
  • Patent number: 10384010
    Abstract: Drug delivery device adapted to receive a drug-filled cartridge comprises a piston drive member for expelling a dose of drug from a loaded cartridge, a motor for driving the piston drive member, a rechargeable electric power source, an electrical connector allowing an external connector of a power source to be connected for recharging the power source, and a controller for controlling operation of the motor. The controller is adapted to detect a condition indicative of an external power source being connected to the electrical connector and subsequently disable the expelling assembly to thereby prevent that drug can be expelled from a loaded cartridge when an external power source has been connected to the electrical connector.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: August 20, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Mikkel Schouenborg Grubbe, Mads Moeller, Carsten Schau Andersen, Thomas Soerensen, Jesper Hoeholt, Steffen Mews, Pete Brockmeier, Bjoern Gullak Larsen
  • Patent number: 10383996
    Abstract: A medication delivery device comprises an injection device having a reservoir comprising a medicament to be ejected, and a sensor arranged to detect an ejection of the medicament from the injection device, the sensor being arranged to output a signal comprising ejecting information, and a processor for collecting and storing the ejection information.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: August 20, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Thomas Miller, Christian Peter Enggaard, Preben Nielsen, Bodo von Münchow
  • Patent number: 10384013
    Abstract: Add-on module (100) for logging the value of an expelled dose from a pen-type drug injector (200), comprising a magnetic sensor system comprising first and second sensor means (745/746) as well as a mechanical dose setting and expelling mechanism comprising a magnetic clutch element (240/740) which rotates during drug expelling. The system further comprises processor means configured to determine (i) on the basis of measured values from the first sensor means, a rotational position of the clutch element, (ii) on the basis of measured values from the second sensor means, a high-speed condition in which the rotational speed of the clutch element exceeds a given threshold level, and (iii) indicate an error state if the high-speed condition is detected.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: August 20, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Nikolaj Frogner Krusell, Preben Mikael Nielsen, Jens Christian Andersen
  • Publication number: 20190248852
    Abstract: The invention relates to MIC-1 compounds. More specifically it relates to compounds comprising a MIC-1 polypeptide and an N-terminal amino acid extension, wherein said extension consists of 3 to 36 amino acid residues and where the compound has a calculated pI lower than 6.5. The compounds of the invention have MIC-1 activity. 5 The invention also relates to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable excipients, as well as the medical use of the compounds.
    Type: Application
    Filed: May 24, 2017
    Publication date: August 15, 2019
    Applicants: Novo Nordisk A/S, Novo Nordisk A/S
    Inventors: Xujia Zhang, Xiang Gao, Hongtao Guan, Henning Thoegersen, Kristian Sass-Oerum, Lars Fogh Iversen, Per Noergaard, Sebastian Beck Joergensen, Kristian Tage Hansen, Yi Wang
  • Patent number: 10376644
    Abstract: A system comprising a sensor assembly adapted to measure a magnetic field, and a mechanical assembly comprising an indicator element with a magnet moving together therewith, the magnet being configured to generate a spatial magnetic field which relative to the sensor assembly varies corresponding to the spatial position and orientation of the magnet, wherein the indicator element is adapted to both rotate and move axially during operation of the assembly. Processor means is configured to determine on the basis of measured values both a rotational position and an axial position of the indicator element.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: August 13, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Nikolaj Frogner Krusell, Nikolaj Eusebius Jakobsen
  • Patent number: 10376652
    Abstract: The present invention relates to a handheld mechanical injection device by which set doses of a liquid medicament can be injected from a medical reservoir. The medicament is expelled through an injection needle by release of a power reservoir in the device, the power reservoir being fully or partially released by actuation of a user operable release member being positioned at or near an upper end of the injection device, the upper end being that end of the injection device which is opposite the injection needle.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: August 13, 2019
    Assignee: Novo Nordisk A/S
    Inventor: Tom Hede Markussen
  • Patent number: 10357616
    Abstract: An injection device with a dose delivering mechanism being adapted to provide a non-visual, e.g. audible and/or tactile, feedback signal when a set dose has been at least substantially injected. A first and a second part of the injection device are adapted to perform a relative rotational movement with respect to each other. The relative rotational movement causes at least two parts of the injection device to abut or engage, and this abutment or engagement causes the non-visual feedback signal to be generated. A very distinct and precise feedback is provided as compared to prior art axial solutions because the generation of the feedback signal is initiated by the relative rotational movement. Feedback signal may be generated by a change in a rotational velocity of at least one part, e.g. by changing the pitch of a threaded portion or by engaging a non-rotating part and a rotating part, thereby causing the non-rotating part to start rotating.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: July 23, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Claus Schmidt Moller, Bo Radmer, Lars Ulrik Nielsen, Christian Peter Enggaard
  • Patent number: 10350369
    Abstract: The present invention relates to an injection apparatus for injecting a pharmaceutical liquid drug into the skin of a user. The injection apparatus can be in form of an injection device carrying a needle cannula or in the shape of a needle assembly (10) attachable to an injection device. The outer shell of the injection apparatus is a protective shield (10) divided into different segments (10a, 10b). These segments are preferably spaced from each other in the longitudinal direction to move individually in the axial direction. Further, the segments are provided with tilting means (14, 15) which are activated to move neighboring segments (10a, 10b) apart upon relative axial movement of one or more segments (10a, 10b) whenever an uneven force is applied to the distal end of the shield.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: July 16, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Emil Gram Spork, Henrik Bengtsson, Christian Hoejris Nielsen
  • Patent number: 10335464
    Abstract: The invention relates to a novel administration regime useful in the treatment of diseases or conditions where administration of insulin will be of benefit. In particular, the invention relates to a long-acting or ultra-long acting insulin for use in treating a disease or condition where administration of insulin will be of benefit, wherein the administration of said insulin includes or consists of one or more of the following steps: (a) obtaining a first data set of the subject, (b) obtaining a second data set of the subject, (c) obtaining a first data structure of the subject, and (d) obtaining a second data structure of the subject. When a determination is made that the at least first data structure, second data structure, first data set, and second data set collectively do contain the set of evaluation information, the device further includes providing the long-acting or ultra-long-acting insulin dose guidance recommendation.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: July 2, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Alan John Michelich, Thomas Dedenroth Miller, Oleksandr Shvets, Anuar Imanbayev, Brad Van Orden
  • Patent number: 10335535
    Abstract: The present invention relates to an injection device for injecting a pharmaceutical liquid drug containing a preservative. The injection device comprises a housing (1) supporting a cartridge (20) having an interior chamber (21) holding the pharmaceutical preservative containing liquid drug to be injected, and a needle cannula (10) having a front part (11) and a back part (12), which back part (12) is adapted to be in liquid communication with the interior chamber (21) of the cartridge (20). The injection device is further provided with a telescopic needle covering shield (30) which distally is provided with a reservoir (31) which holds a liquid containing the same preservatives as in the pharmaceutical preservative containing liquid drug contained in the interior chamber of the cartridge. The telescopic needle covering shield (30) is telescopic movable in relation to the needle cannula (10) by a first resilient member between a first position and a second position.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: July 2, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Henrik Bengtsson, Lars Eilertsen, Casper Bo Jensen, Frederik Kaae Kirk
  • Patent number: 10335462
    Abstract: The invention relates to use of long-acting GLP-1 peptides in certain dosage regimes for the treatment of type 2 diabetes, obesity, etc.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: July 2, 2019
    Assignee: Novo Nordisk A/S
    Inventor: Christine Bjoern Jensen
  • Patent number: 10335536
    Abstract: Disclosed is a medical injection device (1) comprising a needle assembly (20) having a cannula (21) and a telescopic shield (30) for covering the distal tip (23) in a no use situation. The telescopic shield further carries a cleaning reservoir (40) for cleaning the needle cannula between two subsequent injections. The cleaning reservoir is provided with an opening (43) connecting to an overflow reservoir (51/55) such that the cleaning liquid contained in the cleaning reservoir can retract and expand upon temperature changes and does not enter the needle lumen instead. In one example, the overflow reservoir is formed as a channel (51).
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: July 2, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Matias Melander, Christian Hoejris Nielsen, Mie Haraldsted
  • Patent number: 10335369
    Abstract: The invention relates to granules and pharmaceutical compositions comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant obtained by mixing hereof for more than 5 minutes prior to granulation as well as processes for their preparation and use thereof in medicine.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 2, 2019
    Assignee: Novo Nordisk A/S
    Inventor: Thomas Vilhelmsen
  • Publication number: 20190194321
    Abstract: The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.
    Type: Application
    Filed: December 4, 2018
    Publication date: June 27, 2019
    Applicant: Novo Nordisk A/S
    Inventors: Vibeke Westphal STENNICKE, Christine Brender READ, Susanne Nedergaard GRELL, Charlotte WIBERG, Rune SALBO, Anette HENRIKSEN, Soeren PADKJAER
  • Patent number: 10332699
    Abstract: An electronically controlled add-on device with a switch arrangement comprises a powered switch which is open during most of its lifetime, i.e. during both storage and operational use. More specifically, in one embodiment the add-on device comprises a secondary switch so that there are an open and a closed switch. The logics of the electronic circuitry control the circuitry so that the closed switch will be un-powered and the open switch will be powered. When the switch is mechanically changed, both switches are changed by the controller so that the closed switch will be un-powered and the open switch will be powered.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: June 25, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Bo Radmer, Sara Niemann, Nikolai Byskov, Carsten Soerensen, Michael Ejstrup Hansen, Roger Harrington