Patents Assigned to Novo Nordisk Healthcare A/G
  • Pharmaceutical Compositions Comprising Factor VII Polypeptides and Factor XI Polypeptides
    Publication number: 20080058266
    Abstract: Compositions comprising a factor VII or factor VII-related polypeptide and a factor XI or factor XI-related polypeptide, kits comprising the same, and methods of using such compositions (e.g.
    Type: Application
    Filed: September 5, 2007
    Publication date: March 6, 2008
    Applicant: Novo Nordisk HealthCare A/G
    Inventor: Rasmus Rojkjaer
  • Pharmaceutical Composition Comprising Factor VII Polypeptides and Protein S Inhibitors
    Publication number: 20080057059
    Abstract: The present invention relates to a composition comprising factor VII or a factor VII-related polypeptide and a protein S inhibitor, and the use thereof for treating bleeding episodes.
    Type: Application
    Filed: September 5, 2007
    Publication date: March 6, 2008
    Applicant: Novo Nordisk HealthCare A/G
    Inventor: Rasmus Rojkjaer
  • Human coagulation factor VII polypeptides
    Publication number: 20080010693
    Abstract: The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as polynucleotide constructs encoding such variants, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.
    Type: Application
    Filed: April 21, 2005
    Publication date: January 10, 2008
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Egon Persson, Ole Olsen
  • PHARMACEUTICAL COMPOSITION COMPRISING A FACTOR VIIa AND A FACTOR XIII
    Publication number: 20070280920
    Abstract: The present invention relates to the use of a factor VIIa and a factor XIII in the treatment or prophylaxis of bleeding episodes.
    Type: Application
    Filed: May 30, 2007
    Publication date: December 6, 2007
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Lars Petersen, Ulla Hedner, Rasmus Rojkjaer
  • Pharmaceutical composition comprising factor VII polypeptides and TAFI polypeptides
    Patent number: 7291587
    Abstract: The present invention relates to a composition comprising factor VII or a factor VII-related polypeptide, and TAFI or a TAFI-related polypeptide, and the use thereof for treating bleeding episodes.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: November 6, 2007
    Assignee: Novo Nordisk HealthCare A/G
    Inventor: Rasmus Rojkjaer
  • Pharmaceutical Composition Comprising Factor VII Polypeptides and PAI-1 Polypeptide
    Publication number: 20070219135
    Abstract: The present invention relates to a composition comprising factor VII or a factor VII-related polypeptide, and PAI-1 or a PAI-1-related polypeptide, and the use thereof for treating bleeding episodes.
    Type: Application
    Filed: May 31, 2007
    Publication date: September 20, 2007
    Applicant: Novo Nordisk HealthCare A/G
    Inventor: Rasmus Rojkjaer
  • Stabilised solid compositions of factor VII polypeptides
    Publication number: 20070207956
    Abstract: The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: September 25, 2006
    Publication date: September 6, 2007
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Michael Jensen, Birthe Hansen, Troels Kornfelt
  • Coagulation factor VII derivatives
    Patent number: 7235638
    Abstract: The present invention relates to novel human coagulation Factor VII polypeptides, Factor VII derivatives as well as polynucleotide constructs encoding such polypeptides, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: June 26, 2007
    Assignee: Novo Nordisk HealthCare A/G
    Inventor: Egon Persson
  • Virus filtration of liquid Factor VII compositions
    Publication number: 20070142625
    Abstract: The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).
    Type: Application
    Filed: May 23, 2006
    Publication date: June 21, 2007
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Jesper Christensen, Erik Halkjaer, Turid Preuss, Thomas Hansen, Lene Tomoda, Nina Johansen
  • Factor VII glycoforms
    Publication number: 20070122884
    Abstract: The present invention provides preparations of Factor VIIa polypeptides or Factor VIIa-related polypeptides that exhibit predetermined glycoform patterns. The preparations of the invention exhibit improved functional properties and are useful for treating Factor VII-mediated conditions.
    Type: Application
    Filed: December 21, 2006
    Publication date: May 31, 2007
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Hans Pingel, Niels Klausen
  • Uses of factor VIIa or factor VIIa equivalents for treating late complications of trauma
    Publication number: 20070078086
    Abstract: The invention relates to the use of Factor VIIa or a Factor VIIa equivalent for the manufacture of a medicament for preventing late complications in trauma patients.
    Type: Application
    Filed: August 1, 2006
    Publication date: April 5, 2007
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Mads Axelsen, Elisabeth Erhardtsen, Brett Skolnick
  • Use of factor VIIa or factor VIIa equivalents for treating trauma
    Publication number: 20070078087
    Abstract: The invention relates to the use of Factor VIIa or a Factor VIIa equivalent for the manufacture of a medicament for treatment of trauma.
    Type: Application
    Filed: August 2, 2006
    Publication date: April 5, 2007
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Mads Axelsen, Elisabeth Erhardtsen, Brett Skolnick
  • Method for the production of recombinant proteins
    Publication number: 20070072271
    Abstract: The present invention relates to a process for the production of recombinant polypeptides in leukocytes.
    Type: Application
    Filed: July 5, 2006
    Publication date: March 29, 2007
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Jan Nehlin, Ivan Svendsen
  • Novel compounds
    Publication number: 20070037746
    Abstract: The present invention relates to novel coagulation factor FVIIa polypeptides.
    Type: Application
    Filed: August 1, 2006
    Publication date: February 15, 2007
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Henrik Ostergaard, Egon Persson
  • Human coagulation factor VII variants
    Patent number: 7176288
    Abstract: The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as nucleic acid constructs encoding such variants, vectors and host cells comprising and expressing the nucleic acid, pharmaceutical compositions, uses and methods of treatment.
    Type: Grant
    Filed: September 13, 2001
    Date of Patent: February 13, 2007
    Assignee: Novo Nordisk HealthCare A/G
    Inventors: Egon Persson, Ole Hvilsted Olsen
  • Stabilised compositions of Factor VII
    Publication number: 20070021338
    Abstract: The invention relates to chemically as well as physically stable kits and compositions comprising polypeptides, in particular Factor VII or Factor VII-related polypeptides, such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: June 9, 2006
    Publication date: January 25, 2007
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Birthe Hansen, Michael Jensen, Troels Kornfelt
  • Pharmaceutical composition comprising a factor VII polypeptide and epsilon-aminocaproic acid
    Publication number: 20060293241
    Abstract: The present invention relates to compositions or kits comprising factor VII or a factor VII-related polypeptide and epsilon-aminocaproic acid, and the use thereof for the treatment of bleeding episodes or enhancement of hemostasis.
    Type: Application
    Filed: August 28, 2006
    Publication date: December 28, 2006
    Applicant: Novo Nordisk HealthCare A/G
    Inventor: Rasmus Rojkjær
  • Combined use of factor VII polypeptides and factor VIII polypeptides
    Publication number: 20060276398
    Abstract: The invention concerns a pharmaceutical preparation comprising a factor VII or factor VII-related polypeptide and a factor VIII or factor VIII-related polypeptide. The invention also concerns use of a factor VII or factor VII-related polypeptide and a factor VIII or factor VIII-related polypeptide for manufacture of a medicament for pharmaceutical use as well as methods for prevention or treatment of bleeding episodes in subjects.
    Type: Application
    Filed: July 25, 2006
    Publication date: December 7, 2006
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Jens Knudsen, Ulla Hedner, Rasmus Rojkjaer
  • Hybird molecules having factor VII/VIIa activity
    Publication number: 20060258851
    Abstract: The present invention relates to novel human coagulation Factor VII/VIIa proteins having coagulant potential/activity as well as pharmaceutical compositions comprising the polypeptides, uses and methods of treatment. In particular, the present invention relates to novel, semi synthetic analogues of human coagulation Factor VII and VIIa (FVII and FVIIa) as well as to a method of their production.
    Type: Application
    Filed: March 30, 2006
    Publication date: November 16, 2006
    Applicant: Novo Nordisk HealthCare A/G
    Inventor: Nils Johansen
  • Human coagulation Factor VII variants
    Publication number: 20060252129
    Abstract: The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as nucleic acid constructs encoding such variants, vectors and host cells comprising and expressing the nucleic acid, pharmaceutical compositions, uses and methods of treatment.
    Type: Application
    Filed: July 14, 2006
    Publication date: November 9, 2006
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Egon Persson, Ole Olsen