Patents Assigned to Novogen Research Pty. Ltd.
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Publication number: 20120003178Abstract: Provided herein are methods for predicting the response of a subject to administration of a glucan prior to said administration, comprising in one embodiment: isolating at least one cell from the subject, wherein the cell is capable of being stimulated by the glucan; contacting the at least one cell with the glucan and incubating for a period of time and under suitable conditions sufficient to stimulate the cell(s) thereby inducing a change in the level of expression, activity and/or secretion of one or more biomarkers from the cell(s); and determining the level of expression and/or secretion of the at least biomarker, wherein the level of expression, activity and/or secretion is predictive of the response of the subject to administration of the glucan.Type: ApplicationFiled: February 19, 2009Publication date: January 5, 2012Applicant: NOVOGEN RESEARCH PTY LTDInventor: Reinhard Koenic
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Publication number: 20120003337Abstract: Compositions enriched with natural phyto-oestrogens or analogues thereof selected from Genistein, Daidzein, Formononetin and Biochanin A. These may be used as food additives, tablets or capsules for promoting health in cases of cancer, pre-menstrual syndrome, menopause or hypercholesterolaemia.Type: ApplicationFiled: April 1, 2011Publication date: January 5, 2012Applicant: NOVOGEN RESEARCH PTY LTD.Inventor: Graham Edmund Kelly
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Publication number: 20110305782Abstract: This invention relates to natural products containing phyto-oestrogens, or phyto-oestrogen analogues, which have various beneficial physiological effects in man, and which have a variety of uses, such as to promote good health and as a dietary additive, for example. The invention describes a method of improving the health of a human by administering to the human a health supplementing amount of a phyto-oestrogen selected from genistein, daidzein formononentin and/or biochanin A. A health supplement comprising a health supplementary amount of a phyto-oestrogen selected from genisten daidzein formononentin and/or biochanin A, is also described. Preferably, the supplement also comprises at least one dietary suitable excipient, diluent, carrier or food, and may be in the form of a tablet or capsule, for example. Ideally, the phyto-oestrogen is extracted from red clover or from soya, although any source rich in isoflavones may also be used.Type: ApplicationFiled: June 17, 2011Publication date: December 15, 2011Applicant: NOVOGEN RESEARCH PTY LTD.Inventor: Graham Edmund Kelly
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Publication number: 20110301118Abstract: The present invention relates to methods for the treatment of skin wounds or lesions, and connective tissue damage or injury, comprising administering to a subject an effective amount of a glucan composition. Also provided are methods for the promotion of wound healing and tissue regeneration.Type: ApplicationFiled: October 15, 2009Publication date: December 8, 2011Applicant: NOVOGEN RESEARCH PTY LTDInventor: Reinhard Koenig
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Publication number: 20110212989Abstract: Therapeutic method of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H or RACO wherein Ra is C1-10alkyl or an amino acid, R2 is H, OH or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c) or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (f) and B is (g) where R3 is H, CORA where RA is as previously defined, CO2RC where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CO2RC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, anType: ApplicationFiled: May 6, 2011Publication date: September 1, 2011Applicant: NOVOGEN RESEARCH PTY LTDInventors: Graham Edmund KELLY, George Eustace Joannou
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Patent number: 7915308Abstract: Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (1), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R3 is H, CORA where RA is as previously defined, CO2RC where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CO2RC wherType: GrantFiled: July 22, 2008Date of Patent: March 29, 2011Assignee: Novogen Research Pty LtdInventors: Graham Edmund Kelly, George Eustace Joannou
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Publication number: 20110065911Abstract: The present invention relates to a method for producing a glucan product substantially free of endotoxin contamination.Type: ApplicationFiled: February 19, 2009Publication date: March 17, 2011Applicant: NOVOGEN RESEARCH PTY LTDInventor: Reinhard Koenig
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Patent number: 7906554Abstract: This invention relates to combination therapies involving anticancer chemotherapeutic agents and isoflavones or analogues thereof. The invention further relates to compounds, methods and therapeutic uses involving, containing, comprising, including and/or for preparing platinum-isoflavonoid complexes suitable for use in the combination therapies of the invention.Type: GrantFiled: October 2, 2003Date of Patent: March 15, 2011Assignee: Novogen Research Pty LtdInventor: Graham Edmund Kelly
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Patent number: 7906660Abstract: Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained in high purity and in near quantitative yields whilst employing pharmaceutically acceptable reagents and solvents.Type: GrantFiled: May 25, 2006Date of Patent: March 15, 2011Assignee: Novogen Research Pty LtdInventors: Andrew Heaton, Naresh Kumar
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Patent number: 7776843Abstract: The present invention is directed to methods of using glucan compositions, comprising water insoluble microparticulate glucans, in the treatment of bone injuries. The water insoluble microparticulate glucans used in the compositions comprise branched ?-(1.3)(1.6) glucan. The glucan compositions used in the present invention are essentially free of unbranched ?-(1.3)(1.6) glucan and non-glucan components.Type: GrantFiled: August 4, 2006Date of Patent: August 17, 2010Assignee: Novogen Research Pty. Ltd.Inventor: Graham Edmund Kelly
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Publication number: 20100152284Abstract: Provided herein are methods for treating or preventing neuropathy, neuropathy-related conditions, wherein the neuropathy or neuropathy-related conditions are induced by, or otherwise associated with, treatment of the subject with at least one chemotherapeutic agent, the methods comprising administering an effective amount of an isoflavonoid compound of formula (I). Also provided are methods for the treatment of nerve damage. Also provided are uses of isoflavonoid compounds of formula (I) in the treatment of neuropathy, neuropathy-related conditions and nerve damage.Type: ApplicationFiled: October 30, 2007Publication date: June 17, 2010Applicant: NOVOGEN RESEARCH PTY LTDInventors: David Brown, Alan James Husband, Ann M. Turnley
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Publication number: 20100130598Abstract: The present invention relates to methods for inducing or promoting caspase-independent apoptosis in a cell, the method comprising exposing to the cell an effective amount of a compound of formula I as described herein. The invention also relates to methods for treating or preventing diseases and disorders by administering to subjects in need thereof an effective amount of a compound of formula I, wherein the compound induces or promotes caspase-independent apoptosis in at least one cell of the subject.Type: ApplicationFiled: October 19, 2009Publication date: May 27, 2010Applicant: Novogen Research Pty Ltd.Inventors: David Mathew Brown, Alan James Husband, Gil Mor, Ewan M. Tytler
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Patent number: 7714151Abstract: Aminated isoflavonoid synthesized by aminating the 4-keto group of isoflavanone and isoflavanone ring systems, pharmaceutical compositions containing same and uses thereof as therapeutic agents.Type: GrantFiled: November 3, 2003Date of Patent: May 11, 2010Assignee: Novogen Research Pty LtdInventors: Graham Edmund Kelly, Andrew Heaton, Jane Faragalla, John Bremner
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Patent number: 7700644Abstract: Novel compounds based on phenyl-substituted naphtho[1,2-g]chrysene compounds (A) are described. The compounds are obtainable by dimerisation of 3-phenylchroman (isoflavonoid) ring systems (B). Methods of synthesis of the novel dimeric compounds, compositions containing same and use of the dimers as therapeutic agents are also described.Type: GrantFiled: March 24, 2006Date of Patent: April 20, 2010Assignee: Novogen Research Pty LtdInventors: Andrew Heaton, Naresh Kumar
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Patent number: 7648968Abstract: The present invention is directed to methods of using glucan compositions, comprising water insoluble microparticulate glucans, in the treatment of dermal ulcers. The water insoluble microparticulate glucans used in the compositions comprise branched ?-(1,3)(1,6) glucan. The glucan compositions used in the present invention are essentially free of unbranched ?-(1,3)(1,6) glucan and non-glucan components.Type: GrantFiled: August 4, 2006Date of Patent: January 19, 2010Assignee: Novogen Research Pty. Ltd.Inventor: Graham Edmund Kelly
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Publication number: 20090317490Abstract: Novel substituted chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.Type: ApplicationFiled: August 31, 2009Publication date: December 24, 2009Applicant: Novogen Research PTY LTD.Inventors: Andrew HEATON, Alan HUSBAND
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Patent number: 7622575Abstract: The present invention is directed to methods of using glucan compositions, comprising water insoluble microparticulate glucans, in the treatment of connective tissue injuries. The water insoluble microparticulate glucans used in the compositions comprise branched ?-(1,3)(1,6) glucan. The glucan compositions used in the present invention are essentially free of unbranched ?-(1,3)(1,6) glucan and non-glucan components.Type: GrantFiled: August 4, 2006Date of Patent: November 24, 2009Assignee: Novogen Research Pty. Ltd.Inventor: Graham Edmund Kelly
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Patent number: 7601855Abstract: Novel substituted chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.Type: GrantFiled: September 21, 2005Date of Patent: October 13, 2009Assignee: Novogen Research Pty LtdInventors: Andrew Heaton, Alan Husband
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Publication number: 20090233999Abstract: Isoflavone compounds and analogues thereof, compositions containing same and therapeutic methods of treatment involving same are described.Type: ApplicationFiled: November 6, 2008Publication date: September 17, 2009Applicant: NOVOGEN RESEARCH PTY LTDInventors: ANDREW HEATON, NARESH KUMAR, GRAHAM EDMUND KELLY, ALAN HUSBAND
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Patent number: RE40792Abstract: Compositions enriched with natural phyto-oestrogens or analogues thereof selected from Genistein, Daidzein, Formononetin and Biochanin A. These may be used as food additives, tablets or capsules for promoting health in cases of cancer, pre-menstrual syndrome, menopause or hypercholesterolaemia.Type: GrantFiled: May 19, 1993Date of Patent: June 23, 2009Assignee: Novogen Research Pty LtdInventor: Graham Edmund Kelly