Patents Assigned to NOVOGY, INC.
  • Patent number: 10760105
    Abstract: Disclosed are transformed cells comprising one or more genetic modifications that increase the lipid content of the cell, e.g., relative to an unmodified cell of the same type. Also disclosed are methods for increasing the lipid content of a cell by increasing the activity of one or more proteins in the cell and/or by decreasing the activity of one or more proteins in the cell.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: September 1, 2020
    Assignee: NOVOGY, INC.
    Inventors: Arthur J. Shaw, IV, Johannes Pieter Van Dijken, Annapurna Kamineni, Jonathan Friedlander, Vasiliki Tsakraklides, Maureen Hamilton, Elena E. Brevnova
  • Patent number: 10724041
    Abstract: Disclosed are nucleotide sequences and corresponding amino acid sequences of Arxula adeninivorans genes that can be utilized to manipulate the lipid content and/or composition of a cell. Methods and compositions for utilizing this information are disclosed to increase the lipid content or modify the lipid composition of a cell by either increasing or decreasing the activity of certain genetic targets.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: July 28, 2020
    Assignee: NOVOGY, INC.
    Inventors: Elena E. Brevnova, Arthur J. Shaw, IV, Johannes P. Van Dijken
  • Patent number: 10260052
    Abstract: DGA1 catalyzes the final enzymatic step for converting acyl-CoA and 1,2-diacylglycerol to triacylglycerols (TAG) and CoA in yeast. Disclosed are methods for expression in an oleaginous yeast host of polynucleotide sequences encoding DGA1 from Rhodosporidium toruloides, Lipomyces starkeyi, Aurantiochytrium limacinium, Aspergillus terreus, or Claviceps purpurea. Also described herein are engineered recombinant host cells of Yarrowia lipolytica comprising heterologous DGA1 polynucleotides encoding DGA1 proteins, or functionally active portions thereof, having the capability of producing increased lipid production and possessing the characteristic of enhanced glucose consumption efficiency.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: April 16, 2019
    Assignee: NOVOGY, INC.
    Inventors: Elena E. Brevnova, Arthur J. Shaw, IV, Emily H. Greenhagen
  • Publication number: 20160362663
    Abstract: DGA1 catalyzes the final enzymatic step for converting acyl-CoA and 1,2-diacylglycerol to triacylglycerols (TAG) and CoA in yeast. Disclosed are methods for expression in an oleaginous yeast host of polynucleotide sequences encoding DGA1 from Rhodosporidium toruloides, Lipomyces starkeyi, Aurantiochytrium limacinium, Aspergillus terreus, or Claviceps purpurea. Also described herein are engineered recombinant host cells of Yarrowia lipolytica comprising heterologous DGA1 polynucleotides encoding DGA1 proteins, or functionally active portions thereof, having the capability of producing increased lipid production and possessing the characteristic of enhanced glucose consumption efficiency.
    Type: Application
    Filed: February 24, 2015
    Publication date: December 15, 2016
    Applicant: NOVOGY, INC.
    Inventors: Elena E. Brevnova, Arthur J. Shaw, Emily H. Greenhagen
  • Publication number: 20160115492
    Abstract: Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical nitrogen sources, such as melamine and cyanamide. Fermentation methods using the genetically engineered organisms are also described. The methods of the invention are robust processes for the industrial bioproduction of a variety of compounds, including commodities, fine chemicals, and pharmaceuticals.
    Type: Application
    Filed: January 6, 2014
    Publication date: April 28, 2016
    Applicant: NOVOGY, INC.
    Inventors: Colin R. South, Arthur J. Shaw, IV