Abstract: A dermal conditioning device for creating at feast one fissure, in a stratum corneum layer of an area of skirt, comprising: a non-invasive fissuring generator; a controller coupled to the non-invasive skin fissuring generator, a power supply coupled to the non-invasive skin fissuring generator and the controller; and a housing encasing the non-invasive skin fissuring generator and the controller, wherein the controller controls the non-invasive skin fissuring generator to: generate at least one signal, and apply the at least one signal to dehydrate the area of skin, and stress the external surface of the stratum corneum layer of the area of skin, the stress calibrated to produce a strain on the stratum corneum layer causing a formation of at least one fissure in the stratum corneum layer when the area of skin is dehydrated, while maintaining a pre-fissure immune status of the area of skin.

Abstract: A dermal conditioning device is for creating at least one pressure point on at least an external surface of an eyelid. The device includes at least one skin tissue lesion generator, at least one controller, a power supply and a housing, the controller coupled to the skin tissue lesion generator. A power supply couples to the skin tissue lesion generator and the controller and the housing encasing the skin tissue lesion generator and the controller. The controller controls the skin tissue lesion generator to generate at least one signal and to apply the signal to stress the external surface of an outer layer of the eyelid, the stress causing a formation of the pressure point on the eyelid without tissue coagulation, thereby activating at least one of a corneal reflex, a menace reflex, and a lacrimation reflex of the eyelid by activating at least one nociceptor on the eyelid.

Abstract: A method of producing an array of sharp tips including a biocompatible coating, wherein the biocompatible coating is thicker at a sharp end of the sharp tips than at a broader section of the sharp tips, the method including providing an array of sharp tips, and coating the sharp end of the sharp tips differentially from coating the broader section of the sharp tips. A method of treating skin including producing a hollow in the skin by heating and mechanically compressing epidermis while retaining a covering of stratum corneum. A method of treating tissue including heating a tip to a temperature suitable for producing a crater in the tissue, advancing the tip toward the tissue, detecting when the tip comes into contact with the tissue by detecting a change in mechanical resistance to the advancing, and measuring the mechanical resistance to the advancing. Related apparatus and methods are also described.

Abstract: A method of producing an array of sharp tips including a biocompatible coating, wherein the biocompatible coating is thicker at a sharp end of the sharp tips than at a broader section of the sharp tips, the method including providing an array of sharp tips, and coating the sharp end of the sharp tips differentially from coating the broader section of the sharp tips. A method of treating skin including producing a hollow in the skin by heating and mechanically compressing epidermis while retaining a covering of stratum corneum. A method of treating tissue including heating a tip to a temperature suitable for producing a crater in the tissue, advancing the tip toward the tissue, detecting when the tip comes into contact with the tissue by detecting a change in mechanical resistance to the advancing, and measuring the mechanical resistance to the advancing. Related apparatus and methods are also described.

Abstract: In accordance with some embodiments of the invention there is provided a device for vaporizing one or more holes in tissue, comprising an array of vaporizing elements and a heating element configured to heat the vaporizing elements, wherein a geometry of at least a portion of the vaporizing elements is configured to prevent excessive penetration of other vaporizing elements into the tissue. In some embodiments, the vaporizing elements are heated to a temperature ranging between 300-600 degrees Celsius.

Abstract: A device for vaporizing a hole in tissue, including a vaporizing element, a heating element, configured to heat the vaporizing element, and a mechanism configured to advance the vaporizing element into a specific depth in the tissue and retract the vaporizing element from the tissue within a period of time long enough for the vaporizing element to vaporize the tissue and short enough to limit diffusion of heat beyond a predetermined collateral damage distance from the hole. Related apparatus and methods are also described.

Abstract: A device for vaporizing a hole in tissue, including a vaporizing element, a heating element, configured to heat the vaporizing element, and a mechanism configured to advance the vaporizing element into a specific depth in the tissue and retract the vaporizing element from the tissue within a period of time long enough for the vaporizing element to vaporize the tissue and short enough to limit diffusion of heat beyond a predetermined collateral damage distance from the hole. Related apparatus and methods are also described.

Abstract: A device for vaporizing a hole in tissue, including a vaporizing element, a heating element, configured to heat the vaporizing element, and a mechanism configured to advance the vaporizing element into a specific depth in the tissue and retract the vaporizing element from the tissue within a period of time long enough for the vaporizing element to vaporize the tissue and short enough to limit diffusion of heat beyond a predetermined collateral damage distance from the hole. Related apparatus and methods are also described.