Patents Assigned to Novuspharma S.p.A.
  • Oncosuppressive gene
    Patent number: 7189840
    Abstract: Isolation and characterization of an oncosuppressive gene which is involved in the apoptotic process and is regulated by p53 ad p73, polypeptide thereby encoded, sequences involved in gene regulation and genetic constructs thereof.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: March 13, 2007
    Assignee: Novuspharma S.p.A.
    Inventors: Massimo Broggini, Maurizio D'Incalci
  • 2-(1H-indol-3-yl)-2-oxo-acetic acid amides with antitumor activity
    Patent number: 6987122
    Abstract: 2-(1H-Indol-3-yl)-2-oxo-acetamide derivatives of formula (I) having antitumor activity in particular against solid tumors, specifically colon and lung tumors.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: January 17, 2006
    Assignee: Novuspharma S.p.A.
    Inventors: Ernesto Menta, Nicoletta Pescalli
  • 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity
    Patent number: 6753342
    Abstract: 2-(1H-Indol-3-yl)-2-oxo-acetamides having antitumor activity, in particular against solid tumors, more precisely colon and lung tumors, of the following formula I: wherein Y is an oxygen of sulfur atom and X, R1, R2, R3, R4 and R5 are as defined in claim 1.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: June 22, 2004
    Assignee: Novuspharma S.p.A.
    Inventors: Ernesto Menta, Nicoletta Pescalli
  • Nitrates of bis-platinum complexes with polyamine ligands
    Patent number: 6596889
    Abstract: Nitrates of Bis-platinum complexes with polyamine ligands of formula (I) having antitumor activity and pharmaceutical compositions containing said compounds as active principles.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: July 22, 2003
    Assignee: Novuspharma S.p.A.
    Inventors: Ernesto Menta, Giovanni Da Re
  • Bis-phosphonate confugates with alkylating moieties having antitumor activity
    Patent number: 6207655
    Abstract: The present invention relates to conjugates of 3-carboxy-4,4′-dihydroxyphosphorylbutenoic acids with alkylating agents, derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: March 27, 2001
    Assignee: Novuspharma S.p.A.
    Inventors: Valeria Livi, Silvano Spinelli, Marco Conti, Simonetta D'Alo', Ernesto Menta
  • 2-[2-[(2-hydroxyethyl)amino]ethy [ l]-5-[[2-methylamino)ethyl]amino]indazolo4,3-gh]isoquinolin-6(2H)-one as antitumor agent
    Patent number: 6034092
    Abstract: The present invention relates to 2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-methylamino)ethyl]amino]indazolo[ 4,3-gh]isoquinolin-6(2H)-one and the pharmaceutically acceptable acid addition salts thereof, of formula (I). This compound has shown a high a antitumor activity.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: March 7, 2000
    Assignee: Novuspharma S.p.A.
    Inventors: Ernesto Menta, Ambrogio Oliva, Silvano Spinelli, Paul Krapcho