Abstract: The present invention is related to an antagonist of ghrelin, wherein the antagonist is a nucleic acid, and whereby preferably the nucleic acid is binding to ghrelin.
Type:
Grant
Filed:
August 1, 2003
Date of Patent:
July 6, 2010
Assignee:
NOXXON Pharma AG
Inventors:
Steffen Helmling, Dirk Eulberg, Christian Maasch, Sven Klussmann
Abstract: A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism.
Type:
Application
Filed:
August 13, 2009
Publication date:
April 1, 2010
Applicant:
NOXXON PHARMA AG
Inventors:
Christian Lange, Bernd Eschgfaller, Sven Klussmann
Abstract: The present invention is related to a method for the detection of a nucleic acid molecule comprising at least a strand comprising a sequence of nucleotides in a sample, whereby the method comprises the following steps: i) providing a sample containing the nucleic acid molecule; j) providing a capture probe, whereby the capture probe is at least partially complementary to a part of the nucleic acid molecule; k) allowing the capture probe to react with the nucleic acid molecule or a part thereof; and d) detecting whether or not the capture probe is hybridized to the nucleic acid molecule or part thereof.
Type:
Application
Filed:
October 31, 2007
Publication date:
March 11, 2010
Applicant:
NOXXON PHARMA AG
Inventors:
Florian Jarosch, Hilke Hansen, Christian Lange
Abstract: The present invention relates to a modified L-nucleic acid, comprising a L-nucleic acid part and a non-L-nucleic acid part, whereby the L-nucleic acid part is conjugated to the non-L-nucleic acid part and the conjugation of the L-nucleic acid part with the non-L-nucleic acid past leads to a slowed elimination out of the organism, in comparison with a L-nucleic acid which only comprises the L-nucleic acid part, said L-nucleic acid part being a spiegelmer.
Type:
Grant
Filed:
October 25, 2002
Date of Patent:
December 8, 2009
Assignee:
NOXXON Pharma AG
Inventors:
Christian Lange, Bernd Eschgfäller, Sven Klussmann
Abstract: The present invention relates to a process for the production of a conjugate from a polynucleotide and a polysaccharide comprising the steps: a) provision of an aldonic acid of the polysaccharide or of a derivative thereof; b) reaction of the aldonic acid with an alcohol derivative, preferably a carbonate derivative of an alcohol, to an aldonic acid ester, preferably to an activated aldonic acid ester; and c) reaction of the aldonic acid ester with the polynucleotide, wherein the polynucleotide exhibits a functional amino group, wherein the reaction of the aldonic acid with the alcohol derivative in step b) takes place in a dry aprotic polar solvent.
Type:
Application
Filed:
February 8, 2005
Publication date:
November 12, 2009
Applicants:
Supramol Parenteral Colloid GMBH, Noxxon Pharma AG
Abstract: The invention relates to a vasopressin-binding nucleic acid, characterized in that the nucleic acid has a Box 1 segment The and a Box 2 segment, Box 1 having the sequence GAGS, in which W=A or U, preferably W=U, and Box 2 having a sequence comprised of approximately 18 to 24 nucleotides, preferably 21 nucleotides, and a group (G)n being contained four times in the sequence, whereby n=2, 3 or 4.
Type:
Application
Filed:
November 29, 2005
Publication date:
July 16, 2009
Applicant:
Noxxon Pharma AG
Inventors:
Werner Purschke, Dirk Eulberg, Sven Klussmann, Ingo Rohl, Axel Vater
Abstract: The present invention is related to a nucleic acid molecule capable of binding to MCP-1, whereby the nucleic acid molecule is for use as a medicament for the treatment and/or prevention of a chronic disease or chronic disorder, preferably selected from the group consisting of chronic respiratory disease, chronic kidney disease and systemic lupus erythematosus.
Type:
Application
Filed:
November 29, 2008
Publication date:
June 18, 2009
Applicant:
NOXXON PHARMA AG
Inventors:
WERNER PURSCHKE, FLORIAN JAROSCH, DIRK EULBERG, SVEN KLUSSMANN, KLAUS BUCHNER, CHRISTIAN MAASCH
Abstract: The present invention is related to a nucleic acid specifically binding bioactive ghrelin, more preferably n-octanoyl ghrelin, and its use for the diagnosis of grelin mediated diseases and disorders.
Type:
Application
Filed:
November 10, 2004
Publication date:
February 8, 2007
Applicant:
NOXXON Pharma AG
Inventors:
Sven Klussmann, Steffen Helmling, Dirk Eulberg, Christian Maasch, Klaus Buchner
Abstract: The present invention is related to a nucleic acid, preferably binding to ghrelin, whereby the nucleic acid comprises a first stretch Box A, and a second stretch Box B, whereby the first stretch Box A comprises about 25 consecutive nucleotides, the second stretch Box B comprises about six to eight consecutive nucleotides, whereby a 3?-terminal stretch of nucleotides of the first stretch Box A hybridises with the second stretch Box B, whereby upon hybridisation a first double-stranded structure is formed, whereby such first double-stranded structure comprises a bulge.
Type:
Application
Filed:
April 7, 2006
Publication date:
November 16, 2006
Applicant:
NOXXON Pharma AG
Inventors:
Florian Jarosch, Dirk Eulberg, Christian Maasch, Steffen Helmling, Sven Klussmann
Abstract: The invention relates to an antagonist for CGRP and amylin, whereby the antagonist is a nucleic acid and said nucleic acid binds to CGRP or amylin. Said nucleic acid preferably comprises an L-nucleotide.
Type:
Application
Filed:
May 6, 2003
Publication date:
August 17, 2006
Applicant:
NOXXON Pharma AG
Inventors:
Axel Vater, Christian Maasch, Florian Jarosch, Mathias Bell, Steffen Helmling, Bernd Eschgfaller, Elisabeth Moyroud, Sandra Stark, Sven Klussmann, Thorsten Ruppert, Gregor Bahrenberg, Clemens Gillen, Klaus Schiene
Abstract: The present invention provides for amplification methods for cloning and copying genetic material on surfaces as well as copying biological material insofar as, in a broader sense, it can be classified as a ligand-receptor system. The invention therefore relates in particular to a method for propagating ligands and receptors on at least two surfaces, comprising (a) immobilizing a first ligand on a first surface of a substantially solid phase; (b) adding a solution of receptors and binding complementary receptors to the first ligand; (c) transferring the receptor to a second surface and immobilizing the receptor at that location; (d) attaching an additional ligand to the immobilized receptor; and (e) transferring the additional ligand to the first surface and immobilizing it at that location, wherein the steps set forth above may be repeated,multiple times.
Type:
Grant
Filed:
May 25, 2001
Date of Patent:
March 18, 2003
Assignee:
Noxxon Pharma AG
Inventors:
Jens Peter Fürste, Sven Klussmann, Thomas Klein, Günter Von Kiedrowski