Patents Assigned to NPT CO., LTD.
  • Genetically engineered coxsackievirus, and pharmaceutical composition
    Patent number: 12037608
    Abstract: A gene-modified coxsackievirus that is to be used in oncolytic virotherapy and is improved in safety and/or aggressiveness is provided. A gene-modified coxsackievirus that contains a mutated genome with a coxsackievirus B3 wild-type (CVB3-WT) genome inserted with at least one polynucleotide constituted of a target sequence for at least one of either of miR-34a and miR-34c and is suppressed in proliferation in normal cells is provided.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: July 16, 2024
    Assignees: THE UNIVERSITY OF TOKYO, NPT CO., LTD.
    Inventors: Yang Jia, Shohei Miyamoto, Kenichiro Hara, Atsuhumi Iwanaga, Kenzaburo Tani