Abstract: A pharmaceutical composition for preparation of an orally administered liquid solution containing a therapeutically sufficient dose of dissolved balsalazide. The composition further comprises three artificial sweeteners comprising sucralose, acesulfame potassium and ammonium glycyrrhizinate that unexpectedly mitigate the bitter attributes of the orally administered liquid balsalazide solution that would otherwise render the solution unpalatable. More particularly, the present disclosure relates to a composition of the three artificial sweeteners and a therapeutically sufficient dose of balsalazide for the treatment of bowel disorders such as ulcerative colitis. Unit dose sachets of balsalazide disodium 750 mg and 2,250 mg of powder to oral solution are also disclosed.
Type:
Grant
Filed:
June 25, 2019
Date of Patent:
August 6, 2024
Assignee:
NuBioPharma, LLC
Inventors:
Inderjit Kumar Dev, Ajay Kumar Ajmani, Ronald Lee Morris, Jr.
Abstract: A pharmaceutical composition for preparation of an orally administered liquid solution containing a therapeutically sufficient dose of dissolved balsalazide. The composition further comprises three artificial sweeteners comprising sucralose, acesulfame potassium and ammonium glycyrrhizinate that unexpectedly mitigate the bitter attributes of the orally administered liquid balsalazide solution that would otherwise render the solution unpalatable. More particularly, the present disclosure relates to a composition of the three artificial sweeteners and a therapeutically sufficient dose of balsalazide for the treatment of bowel disorders such as ulcerative colitis. Unit dose sachets of balsalazide disodium 750 mg and 2,250 mg of powder to oral solution are also disclosed.
Type:
Application
Filed:
June 25, 2019
Publication date:
December 31, 2020
Applicant:
NuBioPharma, LLC
Inventors:
Inderjit Kumar Dev, Ajay Kumar Ajmani, Ronald Lee Morris, JR.
Abstract: The present invention is a novel oral formulation for the administration of either celecoxib or allopurinol which provides a useful shelf life and is easy to re-suspend.
Type:
Application
Filed:
June 6, 2016
Publication date:
December 7, 2017
Applicant:
NuBioPharma, LLC
Inventors:
Inderjit Kumar Dev, Ajay Kumar Ajmani, Ronald Lee Morris, JR.
Abstract: Administration of an NSAID with at least one dual inhibitor of mPGES-1 and NF-?B plus at least one zwitterionic phospholipid rests in a lessening of side effects and the ability to administer smaller doses of an NSAID without loss of effectiveness.