Patents Assigned to Nucana Biomed Limited
  • PROCESS FOR THE PREPARATION OF GEMCITABINE-[PHENYL(BENZOXY-L-ALANINYL)] PHOSPHATE
    Publication number: 20170166602
    Abstract: The present invention provides a process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate of Formula I in high yield and purity.
    Type: Application
    Filed: July 22, 2015
    Publication date: June 15, 2017
    Applicants: NuCana Biomed Limited, Laurus Labs Private Ltd.
    Inventors: Venkata Lakshmi Narasimha Rao Dammalapati, Mani Bushan Kotala, Shankar Madhavaram
  • Phosphoramidate derivatives of 5-fluoro-2?-deoxyuridine for use in the treatment of cancer
    Patent number: 9655915
    Abstract: Phosphoramidate derivatives of 5-fluoro-2?-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: May 23, 2017
    Assignee: NuCana BioMed Limited
    Inventors: Christopher McGuigan, Jan Balzarini, Magdalena Slusarczyk, Blanka Gonczy, Paola Murziani
  • Phosphoramidite derivatives of gemcitabine for use in the treatment of cancer
    Patent number: 9321798
    Abstract: Phosphorodiamidate derivatives of e.g. gemcitabine are provided for use in treating cancer. In one embodiment, the two amidate motifs each comprises NR?R? where R? is H and R? is CR5R6CO2R7, where R6 is H, R5 is the side chain, including H and C1, of a naturally occurring alpha amino acid, and R7 is branched or unbranched, substituted or unsubstituted, acyclic or cyclic alkyl, including t-butyl-CH2-, benzyl and C3 to C6 cycloalkyl. Formula (I).
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: April 26, 2016
    Assignee: NuCana BioMed Limited
    Inventor: Christopher McGuigan
  • Phosphoramidate derivatives of 5-fluoro-2?-deoxyuridine for use in the treatment of cancer
    Patent number: 9221866
    Abstract: Phosphoramidate derivatives of 5-fluoro-2?-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: December 29, 2015
    Assignee: NuCana Biomed Limited
    Inventors: Christopher McGuigan, Jan Balzarini, Magdalena Slusarczyk, Blanka Gonczy, Paola Murziani
  • Phosphoramidate derivatives of 5-fluoro-2?-deoxyuridine for use in the treatment of cancer
    Patent number: 8933053
    Abstract: Phosphoramidate derivatives of 5-fluoro-2?-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: January 13, 2015
    Assignee: NuCana BioMed Limited
    Inventors: Christopher McGuigan, Jan Balzarini, Magdalena Slusarczyk, Blanka Gonczy, Paola Murziani
  • Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer
    Patent number: 8263575
    Abstract: The compounds are phosphoramidate derivatives of nucleoside compounds such as cladribine, isocladribine, fludarabine and clofarabine useful in the treatment of cancer.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: September 11, 2012
    Assignee: Nucana Biomed Limited
    Inventors: Christopher McGuigan, Kenneth Mills, Costantino Congiatu