Patents Assigned to Nuclea Biotechnologies, Inc.
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Publication number: 20160209412Abstract: The present disclosure provides assays, methods and signature peptides for the identification and quantification of biomarkers in a sample. In particular, the present disclosure relates to the development of mass spectrometric immunoassays with selected reaction monitoring mass spectrometry (MSIA-SRM MS) platforms for biomarker analysis. The MSIA-SRM MS platform may specifically be used for discriminating between particular variants of one or more biomarkers. In addition, the MSIA-SRM platform of the present invention may identify and/or quantify a biomarker and/or its variants present at low abundance in a sample.Type: ApplicationFiled: August 20, 2014Publication date: July 21, 2016Applicant: Nuclea Biotechnologies, Inc.Inventors: Sun W. Tam, Ying Xu, Yunhui Zhang, Christopher S. Drescher, Patrick J Muraca
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Patent number: 9056919Abstract: The invention relates to novel USP2a peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and monitoring of the progression of cancer, as well as for determining or monitoring the efficacy of treatment.Type: GrantFiled: October 24, 2012Date of Patent: June 16, 2015Assignee: NUCLEA BIOTECHNOLOGIES, INC.Inventor: Patrick J. Muraca
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Patent number: 9029512Abstract: The present invention relates to antibodies that immunospecifically bind to phospho-Akt and certain p-Akt substrates. The invention encompasses human and humanized forms of the antibodies and their use in treating cancers and other proliferative disorders. The invention also relates to p-Akt-derived peptides useful for preparing the antibodies. Methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other proliferative disorders using the present antibodies also are disclosed.Type: GrantFiled: November 13, 2009Date of Patent: May 12, 2015Assignee: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Patent number: 8900820Abstract: The present invention provides protein and gene expression profiles indicative of whether a patient afflicted with non-small cell lung cancer is likely to be responsive to treatment with a therapeutic compound that is a EGFR-TK inhibitor. By identifying such responsiveness, a treatment provider may determine in advance those patients who would benefit from such treatment, as well as identify alternative therapies for non-responders. The present invention further provide methods of using the gene and protein expression profiles, and assays for identifying the presence of a gene or protein expression profile in a patient sample.Type: GrantFiled: December 22, 2011Date of Patent: December 2, 2014Assignee: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Publication number: 20140206018Abstract: The present invention relates to antibodies that immunospecifically bind to FAS and certain FAS related proteins. The invention encompasses human and humanized forms of the antibodies and their use in treating cancers and other proliferative disorders. The invention also relates to FAS-derived peptides useful for preparing the antibodies. Methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other proliferative disorders using the present antibodies also are disclosed.Type: ApplicationFiled: February 25, 2014Publication date: July 24, 2014Applicant: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Patent number: 8729239Abstract: The present invention relates to antibodies that immunospecifically bind to FAS and certain FAS related proteins. The invention encompasses human and humanized forms of the antibodies and their use in treating cancers and other proliferative disorders. The invention also relates to FAS-derived peptides useful for preparing the antibodies. Methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other proliferative disorders using the present antibodies also are disclosed.Type: GrantFiled: April 9, 2010Date of Patent: May 20, 2014Assignee: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Publication number: 20140127708Abstract: The invention relates to compositions and methods for detecting, screening, diagnosing or determining the progression of, regression of and/or survival from a proliferative disease or condition, specifically prostate cancer. The invention also provides new assays and kits for the staging or stratifying prostate cancer patients or patients suspected of having prostate cancer.Type: ApplicationFiled: May 8, 2012Publication date: May 8, 2014Applicant: NUCLEA BIOTECHNOLOGIES, INC.Inventor: Patrick J. Muraca
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Publication number: 20140127714Abstract: Methods and immunoassays for the determination of fatty acid synthase (FAS) expression in patients having or suspected of having a proliferative disorder, especially prostate cancer, are disclosed. The sensitive method and assay detect the level of expression of FAS in a biological sample using antibodies that are highly specific for FAS. The method and assay can be used to monitor the progression of cancer, and/or to predict the efficacy of certain treatments or the likelihood of recurrence of the cancer.Type: ApplicationFiled: January 8, 2014Publication date: May 8, 2014Applicant: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Patent number: 8685891Abstract: Methods and immunoassays for the determination of fatty acid synthase (FAS) expression in patients having or suspected of having a proliferative disorder, especially prostate cancer, are disclosed. The sensitive method and assay detect the level of expression of FAS in a biological sample using antibodies that are highly specific for FAS. The method and assay can be used to monitor the progression of cancer, and/or to predict the efficacy of certain treatments or the likelihood of recurrence of the cancer.Type: GrantFiled: August 26, 2010Date of Patent: April 1, 2014Assignee: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Publication number: 20140080737Abstract: The invention provides gene expression profiles (GEPs), protein expression profiles (PEPs) as well as gene/protein expression profiles (GPEPs) and methods for using them to identify metastatic breast cancer patients who are likely to respond to therapy with a VEGF inhibitor. The present invention allows a treatment provider to identify those patients who are most likely to respond to such treatment, and to initiate and/or adjust treatment options for such patients accordingly.Type: ApplicationFiled: April 13, 2012Publication date: March 20, 2014Applicant: NUCLEA BIOTECHNOLOGIES, INC.Inventor: Patrick J. Muraca
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Publication number: 20130237691Abstract: The invention relates to novel USP2a peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and monitoring of the progression of cancer, as well as for determining or monitoring the efficacy of treatment.Type: ApplicationFiled: May 16, 2013Publication date: September 12, 2013Applicant: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Publication number: 20130237449Abstract: The invention relates to novel USP2a peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and monitoring of the progression of cancer, as well as for determining or monitoring the efficacy of treatment.Type: ApplicationFiled: May 16, 2013Publication date: September 12, 2013Applicant: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Publication number: 20130109587Abstract: The invention relates to novel USP2a peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and monitoring of the progression of cancer, as well as for determining or monitoring the efficacy of treatment.Type: ApplicationFiled: October 24, 2012Publication date: May 2, 2013Applicant: NUCLEA BIOTECHNOLOGIES, INC.Inventor: Nuclea Biotechnologies, Inc.
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Publication number: 20130095483Abstract: The invention relates to compositions and methods for detecting, screening, diagnosing or determining the progression of, regression of and/or survival from a proliferative disease or condition, specifically breast cancer. The invention also provides new assays and kits for the staging or stratifying breast cancer patients or patients suspected of having breast cancer.Type: ApplicationFiled: October 15, 2012Publication date: April 18, 2013Applicant: NUCLEA BIOTECHNOLOGIES, INC.Inventor: Nuclea Biotechnologies, Inc.
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Patent number: 8278034Abstract: The invention provides microarrays comprising a plurality of frozen tissues and/or cell samples and methods of preparing and using the same. By using frozen samples, the microarrays provide optimal samples from which to detect the expression of both nucleic acids (e.g., mRNAs) and proteins in high throughput parallel analyses. The microarrays enable gene identification, molecular profiling, selection of promising drug targets, sorting and prioritizing of expressed sequence array data, and the identification of abnormal physiological processes associated with disease.Type: GrantFiled: June 22, 2001Date of Patent: October 2, 2012Assignee: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Publication number: 20120165218Abstract: Methods and immunoassays for the determination of fatty acid synthase (FAS) expression in patients having or suspected of having a proliferative disorder, especially prostate cancer, are disclosed. The sensitive method and assay detect the level of expression of FAS in a biological sample using antibodies that are highly specific for FAS. The method and assay can be used to monitor the progression of cancer, and/or to predict the efficacy of certain treatments or the likelihood of recurrence of the cancer.Type: ApplicationFiled: August 26, 2010Publication date: June 28, 2012Applicant: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Publication number: 20120149594Abstract: The invention provides gene expression profiles (GEPs), protein expression profiles (PEPs) as well as gene/protein expression profiles (GPEPs) and methods for using them to identify those patients who are likely to progress to breast cancer after detection of suspicious calcifications and/or fibrocystic disease by standard imaging techniques, e.g., mammography, MRI or ultrasound. The present invention further allows a treatment provider to identify those patients who are most likely to develop breast cancer to initiate and/or adjust treatment options for such patients accordingly.Type: ApplicationFiled: November 23, 2011Publication date: June 14, 2012Applicant: NUCLEA BIOTECHNOLOGIES, INC.Inventor: PATRICK J. MURACA
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Patent number: 8129125Abstract: The present invention provides protein and gene expression profiles indicative of whether a patient afflicted with non-small cell lung cancer is likely to be responsive to treatment with a therapeutic compound that is a EGFR-TK inhibitor. By identifying such responsiveness, a treatment provider may determine in advance those patients who would benefit from such treatment, as well as identify alternative therapies for non-responders. The present invention further provide methods of using the gene and protein expression profiles, and assays for identifying the presence of a gene or protein expression profile in a patient sample.Type: GrantFiled: September 22, 2008Date of Patent: March 6, 2012Assignee: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Patent number: D714959Type: GrantFiled: November 6, 2012Date of Patent: October 7, 2014Assignee: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
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Patent number: D718800Type: GrantFiled: November 14, 2012Date of Patent: December 2, 2014Assignee: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca