Patents Assigned to NUCLEIN, LLC
  • Apparatus and methods for molecular diagnostics
    Patent number: 12623227
    Abstract: This disclosure relates to apparatus and methods for molecular diagnostics. Certain embodiments include a piston cycled from a first position proximal to a first end of a housing, to a second position proximal to a second end of the housing, and back to the first position proximal to the first end of the housing. In some embodiments, the present disclosure relates to devices, methods, and systems for molecular diagnostics that do not comprise a piston.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: May 12, 2026
    Assignee: NUCLEIN, LLC
    Inventors: Richard Crockett, Alan Blake, Michael Karberg, John Lupher, Chris Clever Nee, Matthew Flint Kepler
  • Lyophilized reagents
    Patent number: 12601542
    Abstract: Provided herein are methods of producing lyophilized reagents with desired physical characteristics, and the lyophilized reagents produced thereby. In particular, lyophilized combinations of reagents are provided with specific physical geometries that provide optimized use in assays and devices.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: April 14, 2026
    Assignees: Northwestern University, Nuclein, LLC
    Inventors: Matthew A. Butzler, Jennifer L. Reed, Sally McFall, Abhishek K. Agarwal, David M. Kelso, Tom Westberg
  • Apparatus and methods for molecular diagnostics
    Patent number: 12390812
    Abstract: This disclosure relates to apparatus and methods for molecular diagnostics. Certain embodiments include a piston cycled from a first position proximal to a first end of a housing, to a second position proximal to a second end of the housing, and back to the first position proximal to the first end of the housing. In some embodiments, the present disclosure relates to devices, methods, and systems for molecular diagnostics that do not comprise a piston.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: August 19, 2025
    Assignee: NUCLEIN, LLC
    Inventors: Richard Crockett, Alan Blake, Michael Karberg, John Lupher, Chris Clever Nee, Matthew Flint Kepler
  • DIRECT LYSIS APPARATUS AND METHODS FOR MOLECULAR DIAGNOSTICS
    Publication number: 20240002916
    Abstract: This disclosure relates to direct lysis apparatus and methods for molecular diagnostics. Certain embodiments include a piston cycled from a first position proximal to a first end of a housing, to a second position proximal to a second end of the housing, and back to the first position proximal to the first end of the housing. In some embodiments, the present disclosure relates to devices, methods, and systems for molecular diagnostics that do not comprise a piston.
    Type: Application
    Filed: November 16, 2021
    Publication date: January 4, 2024
    Applicant: NUCLEIN, LLC
    Inventors: Richard CROCKETT, Alan BLAKE, Brittan PASLOSKE, Jeffrey SHELTON, Michael KARBERG, Ehren ACHEE, James Doug WEHRLY, Alex ILES, John LUPHER
  • APPARATUS AND METHODS FOR MOLECULAR DIAGNOSTICS
    Publication number: 20240001369
    Abstract: This disclosure relates to apparatus and methods for molecular diagnostics. Certain embodiments include a piston cycled from a first position proximal to a first end of a housing, to a second position proximal to a second end of the housing, and back to the first position proximal to the first end of the housing. In some embodiments, the present disclosure relates to devices, methods, and systems for molecular diagnostics that do not comprise a piston.
    Type: Application
    Filed: November 16, 2021
    Publication date: January 4, 2024
    Applicant: NUCLEIN, LLC
    Inventors: Richard CROCKETT, Alan BLAKE, Michael KARBERG, Ehren ACHEE, James Doug WEHRLY, Alex ILES, John LUPHER
  • APPARATUS AND METHODS FOR MOLECULAR DIAGNOSTICS
    Publication number: 20230105360
    Abstract: This disclosure relates to apparatus and methods for molecular diagnostics. Certain embodiments include a piston cycled from a first position proximal to a first end of a housing, to a second position proximal to a second end of the housing, and back to the first position proximal to the first end of the housing. In some embodiments, the present disclosure relates to devices, methods, and systems for molecular diagnostics that do not comprise a piston.
    Type: Application
    Filed: March 9, 2020
    Publication date: April 6, 2023
    Applicant: NUCLEIN, LLC
    Inventors: Richard CROCKETT, Alan BLAKE, Michael KARBERG, John LUPHER, Chris Clever NEE, Matthew Flint KEPLER
  • APPARATUS AND METHODS FOR MOLECULAR DIAGNOSTICS
    Publication number: 20220080427
    Abstract: This disclosure relates to apparatus and methods for molecular diagnostics. Certain embodiments include a piston cycled from a first position proximal to a first end of a housing, to a second position proximal to a second end of the housing, and back to the first position proximal to the first end of the housing. In some embodiments, the present disclosure relates to devices, methods, and systems for molecular diagnostics that do not comprise a piston.
    Type: Application
    Filed: December 19, 2019
    Publication date: March 17, 2022
    Applicant: NUCLEIN, LLC
    Inventors: Richard CROCKETT, Alan BLAKE, Michael KARBERG, John LUPHER, Chris Clever NEE, Matthew Flint KEPLER
  • Molecular diagnostic device
    Patent number: D977138
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: January 31, 2023
    Assignee: NUCLEIN, LLC
    Inventors: Richard Crockett, Alan Blake, Kevin Brase, Ehren Achee, Douglas Hammond