Patents Assigned to Numaferm GmbH
  • Variants of hlya and uses thereof
    Patent number: 12612436
    Abstract: Polypeptides comprising hemolysin A (Hly A) fragments and/or variants and a peptide or polypeptide of interest in form of a fusion protein that exhibits improved expression and secretion as well as increased solubility and stability and improved renaturation efficiency. Also encompassed are nucleic acids encoding these polypeptides. host cells that comprise said nucleic acids, and methods and uses for protein expression using said nucleic acids, host cells and polypeptides.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: April 28, 2026
    Assignee: NUMAFERM GmbH
    Inventor: Christian Schwarz
  • Methods for the expression of peptides and proteins
    Patent number: 10443081
    Abstract: The present invention lies in the field of molecular biology, recombinant peptide and protein expression and relates to methods comprising nucleic acid sequences comprising allocrites of T1SSs or fragments thereof for the efficient production of recombinant Pe OIs and Pr OI. The allocrites or fragments thereof improve the expression of PeOI and Pr OI as IB and function as IB-tags.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: October 15, 2019
    Assignee: Numaferm GmbH
    Inventors: Lutz Schmitt, Christian Schwarz, Sander Hendrikus Joannes Smits