Abstract: The invention is directed in various aspects to a compression fixation system that includes coupling components and locking assemblies for connecting two or more separate elements in a fixed arrangement. For example, the system is useful for connecting and compressing two or more elements selected from bones and bone fragments. The system includes a substantially linear coupling component, such as, for example, a Kirschner Wire (“K-Wire”) and locking assembly elements that engage with the coupling component in a coaxial orientation. The coupling component includes at least a linear portion and an anchor portion, the anchor portion configured to be fixed within or adjacent to a first one of the elements to be connected and the linear portion configured to be fixed adjacent to a second one of the elements to be connected, where the locking assembly is attached coaxially with and locked against the second element to achieve compression and fixation.