Patents Assigned to Numat Biomedical S.L.
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Patent number: 9849212Abstract: The present invention provides a biocompatible implant comprising one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof, wherein an antioxidant compound selected from the group of flavonoids or methoxytryptophols, an ester thereof, a pharmaceutically acceptable salt thereof or a combination thereof, is/are coated to at least a part of a metal, metal alloy or metal oxide surface of said biocompatible implant. This implant is useful for replace bone tissue in vertebrate animals, and furthermore restore the normal function of said tissue, mainly due to its ability of induce osseointegration and soft tissue attachment.Type: GrantFiled: April 18, 2013Date of Patent: December 26, 2017Assignee: NUMAT BIOMEDICAL S.L.Inventors: Marta Monjo Cabrer, Joana María Ramis Morey, Alba Córdoba Insensé, María Satué Sahún, Manuel Gómez Florit
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Patent number: 9433710Abstract: The present invention relates to a biocompatible implant comprising one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof, wherein a compound selected from the group consisting of an IP, an ester of an IP, and/or a pharmaceutically acceptable salt thereof, or a combination thereof, is/are covalently bound to at least a part of a metal, metal alloy or metal oxide surface of said biocompatible implant. The covalent bond between the IP and the metal, metal alloy or metal oxide surface can be further assisted by the use of a linker. An implant according to the invention provides for a modulated and/or improved osseointegrative effect when implanted into a body, such as a mammalian body, by virtue of the coating comprising covalently bound phytate.Type: GrantFiled: December 26, 2012Date of Patent: September 6, 2016Assignees: LABORATORIES SANIFIT, S. L., NUMAT BIOMEDICAL, S. L.Inventors: Marta Monjo Cabrer, Joan Perelló Bestard, Joana María Ramis Morey, Fernando Tur Espinosa, María del Mar Arriero Sánchez, Eva Martín Becerra, Bernat Isern Amengual, Rubén Henríquez Paláez
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Publication number: 20160082147Abstract: The present invention provides a biocompatible implant comprising one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof, wherein an antioxidant compound selected from the group of flavonoids or methoxytryptophols, an ester thereof, a pharmaceutically acceptable salt thereof or a combination thereof, is/are coated to at least a part of a metal, metal alloy or metal oxide surface of said biocompatible implant. This implant is useful for replace bone tissue in vertebrate animals, and furthermore restore the normal function of said tissue, mainly due to its ability of induce osseointegration and soft tissue attachment.Type: ApplicationFiled: April 18, 2013Publication date: March 24, 2016Applicant: NUMAT BIOMEDICAL S.L.Inventors: Marta MONJO CABRER, Joana María RAMIS MOREY, Alba CÓRDOBA INSENSÉ, María SATUÉ SAHÚN, Manuel GÓMEZ FLORIT
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Patent number: 8821568Abstract: An implant to be used as medical or dental implant, comprising a metallic or polymeric base which is covered by the vitamin D precursor cholecalciferol. The implant can be obtained by direct covering of the polymeric or metallic base with a solution comprising cholecalciferol or also covering the base with the 7-dehydrocholesterol (7-DHC), and subsequently irradiated with UV light to induce the formation of cholecalciferol. Optionally, the coating of the implant may include an antioxidant such as vitamin E. This implant enhances osseointegration in compromised patients by means of the endogenous synthesis and activity of vitamin D in hard and mineralized tissue regeneration. Furthermore, a method to obtain these implants which comprises coating the surface of the implant directly with cholecalciferol or with a specific concentration of 7-DHC and irradiated with UV light to induce the formation of cholecalciferol.Type: GrantFiled: July 26, 2012Date of Patent: September 2, 2014Assignee: Numat Biomedical S.L.Inventors: Ståle Petter Lyngstadaas, Marta Monjo, Christiane Petzold, Jan Erik Ellingsen
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Publication number: 20130017234Abstract: An implant to be used as medical or dental implant, comprising a metallic or polymeric base which is covered by the vitamin D precursor cholecalciferol. The implant can be obtained by direct covering of the polymeric or metallic base with a solution comprising cholecalciferol or also covering the base with the 7-dehydrocholesterol (7-DHC), and subsequently irradiated with UV light to induce the formation of cholecalciferol. Optionally, the coating of the implant may include an antioxidant such as vitamin E. This implant enhances osseointegration in compromised patients by means of the endogenous synthesis and activity of vitamin D in hard and mineralized tissue regeneration. Furthermore, a method to obtain these implants which comprises coating the surface of the implant directly with cholecalciferol or with a specific concentration of 7-DHC and irradiated with UV light to induce the formation of cholecalciferol.Type: ApplicationFiled: July 26, 2012Publication date: January 17, 2013Applicant: Numat Biomedical S.L.Inventors: Ståle Petter Lyngstadaas, Marta Monjo, Christlane Petzold, Jan Erik Ellingsen