Abstract: A method of tracking a plurality of tagged molecules in a cell in two or three dimensions may include receiving a plurality of unambiguous track segments, where each of the plurality of unambiguous track segments may include a plurality of time-valued observations of individual tagged molecules. The method may also include separating the plurality of unambiguous track segments into a plurality of time windows. The method may additionally include, for each of the plurality of unambiguous track segments, deriving one or more data sets representing features of the unambiguous track segment. The method may further include associating a first unambiguous track segment from a first time window with a second unambiguous track segment from a second time window using the one or more data sets.

Abstract: Embodiments of the present invention characterizing the uncertainty of the orbital state of an Earth-orbiting space object hereof using a Gauss von Mises probability density function defined on the n+1 dimensional cylindrical manifold n×. Additionally, embodiments of the present invention can include transforming a Gauss von Mises distribution under a diffeomorphism and approximating the output as a Gauss von Mises distribution. Embodiments of the present invention can also include fusing a prior state represented by a Gauss von Mises distribution with an update report, wherein the update can be either another Gauss von Mises distribution of the same dimension as the prior or an observation related to the prior by a stochastic measurement model. A Gauss von Mises distribution can be calculated from a plurality of reports, wherein the reports are either Gauss von Mises distributions or observations related to the state space by a stochastic measurement model.

Abstract: Embodiments of the present invention characterizing the uncertainty of the orbital state of an Earth-orbiting space object hereof using a Gauss von Mises probability density function defined on the n+1 dimensional cylindrical manifold n×. Additionally, embodiments of the present invention can include transforming a Gauss von Mises distribution under a diffeomorphism and approximating the output as a Gauss von Mises distribution. Embodiments of the present invention can also include fusing a prior state represented by a Gauss von Mises distribution with an update report, wherein the update can be either another Gauss von Mises distribution of the same dimension as the prior or an observation related to the prior by a stochastic measurement model. A Gauss von Mises distribution can be calculated from a plurality of reports, wherein the reports are either Gauss von Mises distributions or observations related to the state space by a stochastic measurement model.

Abstract: Embodiments of the present invention characterizing the uncertainty of the orbital state of an Earth-orbiting space object hereof using a Gauss von Mises probability density function defined on the n+1 dimensional cylindrical manifold n×. Additionally, embodiments of the present invention can include transforming a Gauss von Mises distribution under a diffeomorphism and approximating the output as a Gauss von Mises distribution. Embodiments of the present invention can also include fusing a prior state represented by a Gauss von Mises distribution with an update report, wherein the update can be either another Gauss von Mises distribution of the same dimension as the prior or an observation related to the prior by a stochastic measurement model. A Gauss von Mises distribution can be calculated from a plurality of reports, wherein the reports are either Gauss von Mises distributions or observations related to the state space by a stochastic measurement model.

Abstract: Embodiments of the present invention are directed to reducing the computational cost of propagating the uncertainty in the state of an object, which requires the numerical solution of an initial value problem (IVP) ensemble, by means of a computer. The present invention uses an implicit-Runge-Kutta-based (IRK) method that exploits the proximity of the initial conditions within the IVP ensemble. More specifically, one of the IVPs can be solved over a given time span consisting of one or more time steps with an IRK method, and the resulting trajectory can be recorded. The system of equations that arises on each time step of the IRK method can be solved using various iterative methods. The remaining IVPs can be solved over the same timespan using the same IRK method and time steps, together with the recorded trajectory from the first propagation.