Abstract: The present invention discloses an isolation system, comprising a flexible, portable, disposable membrane with no rigid structures. The membrane inflates from a contracted state having a small form-factor for storage to an inflated state for use. The membrane has an opening on one side defining a chamber within, with the opening having a sealing member that when closed, seals off the chamber. The membrane includes a first port for ingress of gas into the chamber a second port for egress of exhaust gas via an associated exhaust filter assembly, with the second port intrinsically functioning as a passive pressure regulator.