Abstract: A disposable hyperbaric oxygen chamber which is constructed of a flexible, thin-walled, polyethylene plastic bag which is of sufficient size to permit the entry of almost the entire body of an animal, most frequently that of a human, within the bag. The mouth of the bag is pleated so that the pleats can be bunched together into localized bulges to concentrate the volume of oxygen over the area of a wound such as a skin ulcer, lesion or injury. The wall of the bag includes at least one gas supply connector for connecting with a gas supply tube. The wall of the bag also includes a drain connector which is to be connected to a drain tube for removing of accumulated liquid within the internal chamber. The wall of the bag also includes at least one hand access opening which includes a thin-walled tubular glove member with this tubular glove member being locatable exteriorly of the wall of the bag or interiorly of the wall within the internal chamber.