Patents Assigned to NuPotential, Inc.
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Patent number: 8987220Abstract: A method for treating cells and/or nuclear transfer units and/or stem cells in culture with such compounds, individually or in combinations, is described. The method results in a globally hypomethylated genome and a restoration of cell differentiation and/or developmental potential, or potentiality. In addition, a method for the in vitro production of reprogrammed cells which have had differentiation potential (totipotential, pluripotential, or multipotential) restored by demethylating the genome is described.Type: GrantFiled: October 5, 2009Date of Patent: March 24, 2015Assignee: Nupotential, Inc.Inventor: Kenneth J. Eilertsen
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Patent number: 8357666Abstract: The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method for inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises inhibiting the expression of a gene that codes for a protein involved in transcriptional repression. In yet another embodiment, the invention relates to a reprogrammed cell or an enriched population of reprogrammed cells that can have characteristics of an ES-like cell, which can be re- or trans-differentiated into a differentiated cell type.Type: GrantFiled: April 7, 2009Date of Patent: January 22, 2013Assignee: Nupotential, Inc.Inventors: Kenneth J. Eilertsen, Rachel A. Power, Jong S. Rim
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Publication number: 20120322153Abstract: The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method comprising inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises delivering a transcription factor to a cell and exposing said cell to an agent that inhibits the activity, expression, or activity and expression of a gene, which codes for a protein, or a protein involved in transcriptional repression, and selecting a cell, wherein differentiation potential has been restored to said cell. In yet another embodiment, the invention relates to a reprogrammed cell and an enriched population of reprogrammed cells that can have characteristics of an ES-like cell can be re- or trans-differentiated into various differentiated cell types.Type: ApplicationFiled: August 17, 2010Publication date: December 20, 2012Applicant: NUPOTENTIAL, INC.Inventors: Kenneth J. Eilertsen, Jong S. Rim, Rachel A. Power, Jaroslaw Staszkiewicz
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Publication number: 20110059526Abstract: The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method comprising inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises inhibiting the activity of an HDAC with an HDAC inhibitor and inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In still another embodiment, the invention relates to a method for reprogramming comprising exposing a cell to more than one agent to inhibit more than ore type of regulatory protein.Type: ApplicationFiled: November 12, 2009Publication date: March 10, 2011Applicant: NUPOTENTIAL, INC.Inventors: Kenneth J. Eilertsen, Rachel A. Power, Jong S. Rim
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Publication number: 20100159459Abstract: A method for treating cells and/or nuclear transfer units and/or stem cells in culture with such compounds, individually or in combinations, is described. The method results in a globally hypomethylated genome and a restoration of cell differentiation and/or developmental potential, or potentiality. In addition, a method for the in vitro production of reprogrammed cells which have had differentiation potential (totipotential, pluripotential, or multipotential) restored by demethylating the genome is described.Type: ApplicationFiled: October 5, 2009Publication date: June 24, 2010Applicant: NUPOTENTIAL, INC.Inventor: Kenneth J. Eilertsen
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Publication number: 20090275032Abstract: The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method comprising inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises inhibiting the activity of an HDAC with an HDAC inhibitor and inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In still another embodiment, the invention relates to a method for reprogramming comprising exposing a cell to more than one agent to inhibit more than ore type of regulatory protein.Type: ApplicationFiled: April 7, 2009Publication date: November 5, 2009Applicant: NuPotential, Inc.Inventors: Kenneth J. Eilertsen, Rachel A. Power, Jong S. Rim
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Publication number: 20090269763Abstract: The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method for inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises inhibiting the expression of a gene that codes for a protein involved in transcriptional repression. In yet another embodiment, the invention relates to a reprogrammed cell or an enriched population of reprogrammed cells that can have characteristics of an ES-like cell, which can be re- or trans-differentiated into a differentiated cell type.Type: ApplicationFiled: April 7, 2009Publication date: October 29, 2009Applicant: NuPotential, Inc.Inventors: Kenneth J. Eilertsen, Rachel A. Power, Jong S. Rim
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Patent number: 7601699Abstract: A method for treating cells and/or nuclear transfer units and/or stem cells in culture with such compounds, individually or in combinations, is described. The method results in a globally hypomethylated genome and a restoration of cell differentiation and/or developmental potential, or potentiality. In addition, a method for the in vitro production of reprogrammed cells which have had differentiation potential (totipotential, pluripotential, or multipotential) restored by demethylating the genome is described.Type: GrantFiled: August 1, 2006Date of Patent: October 13, 2009Assignee: NuPotential, Inc.Inventor: Kenneth J. Eilertsen
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Publication number: 20090253203Abstract: The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method comprising inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises exposing a cell to a small molecule modulator that induces the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the invention relates to a reprogrammed cell and an enriched population of reprogrammed cells that can have characteristics of an ES-like cell can be re- or trans-differentiated into various differentiated cell types.Type: ApplicationFiled: April 7, 2009Publication date: October 8, 2009Applicant: NuPotential, Inc.Inventors: Kenneth J. Eilertsen, Rachel A. Power