Patents Assigned to NuProbe USA, Inc.
  • Quantitative Multiplex Amplicon Sequencing System
    Publication number: 20230399687
    Abstract: The present invention discloses methods of quantitative multiplex amplicon sequencing system for labeling the original DNA sample with an oligonucleotide barcode sequence by polymerase chain reaction, amplifying the genomic region(s) for high-throughput sequencing and quantifying the sequence in DNA sample. The methods allow analyzing a DNA sample comprising between 1 and 10,000 Target Regions for quantifying potential sequence variants and wildtype molecules.
    Type: Application
    Filed: November 1, 2021
    Publication date: December 14, 2023
    Applicants: NUPROBE USA, INC., WILLIAM MARSH RICE UNIVERSITY
    Inventors: David Y. ZHANG, Peng DAI, Pengying HAO, Alessandro PINTO
  • HIGH SENSITIVITY DETECTION OF MICROSATELLITE LOCI BY BLOCKER DISPLACEMENT AMPLIFICATION WITH MULTIPLE BLOCKERS AND ITS USE IN MICROSATELLITE INSTABILITY DETECTION
    Publication number: 20220298564
    Abstract: This invention describes methods and compositions for selectively enriching unstable variants at a particular microsatellite locus.
    Type: Application
    Filed: October 12, 2021
    Publication date: September 22, 2022
    Applicant: NuProbe USA, Inc.
    Inventor: Yan YAN