Abstract: A monolithic substrate of materials containing within it multiple opened channels of one dimensional macropore have a mesoporous inner surface and a method for making the same, wherein each of the opened channels is isolated from each other. The isolated channels of the one dimensional pore are aligned with and continuously extend through the entire substrate which contains various mesopores in three dimensions. The macropore has preferred pore sizes ranging from about 0.1 micrometers to about 20 micrometers, and the mesopore has a preferred pore size which is less than 500 angstrom.