Abstract: Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disclosed is a method of treating a human papilloma virus infection in a subject infected or suspected of being infected with a human papilloma virus of a first type by administering to the subject a composition containing (1) a heat shock protein or an antigenic fragment thereof, and (2) a protein of a human papilloma virus of a second type or an antigenic fragment thereof, where the first type and second type are different.
Type:
Grant
Filed:
April 26, 2007
Date of Patent:
July 13, 2010
Assignee:
Nventa Biopharmaceuticals Corporation
Inventors:
John R. Neefe, Stephen E. Goldstone, Mark T. Winnett, Marvin Siegel, Leslie J. Boux
Abstract: Immunostimulatory agents, including nucleic acids having one or more than one locked nucleic acid (LNA) nucleosides are provided. The nucleic acids may further comprise CpG motifs. The nucleic acids may be double stranded, and may comprise dsRNA.
Abstract: Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disclosed is a method of treating a human papilloma virus infection in a subject infected or suspected of being infected with a human papilloma virus of a first type by administering to the subject a composition containing (1) a heat shock protein or an antigenic fragment thereof, and (2) a protein of a human papilloma virus of a second type or an antigenic fragment thereof, where the first type and second type are different.
Type:
Grant
Filed:
June 18, 2004
Date of Patent:
May 1, 2007
Assignee:
Nventa Biopharmaceuticals Corporation
Inventors:
John R. Neefe, Stephen E. Goldstone, Mark T. Winnett, Marvin Siegel, Leslie J. Boux