Patents Assigned to Nycomed GmbH
  • Novel Process For The Preparation Of Roflumilast
    Publication number: 20130231374
    Abstract: A composition comprising: roflumilast having a purity of greater than or equal to 99% by weight, and N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-hydroxybenzamide present (relative to roflumilast) in an amount greater than zero and less than 0.1% by weight.
    Type: Application
    Filed: April 10, 2013
    Publication date: September 5, 2013
    Applicant: NYCOMED GMBH
    Inventors: Bernhard KOHL, Bernd MUELLER, Walter PALOSCH
  • Novel Process For The Preparation Of Roflumilast
    Publication number: 20130224299
    Abstract: A method for the treatment of chronic obstructive pulmonary disease (COPD), including administering to a patient suffering from COPD, a therapeutically effective amount of roflumilast having a purity of greater than or equal to 99% by weight, and N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-hydroxybenzamide present (relative to roflumilast) in an amount greater than zero and less than 0.1% by weight.
    Type: Application
    Filed: April 10, 2013
    Publication date: August 29, 2013
    Applicant: NYCOMED GMBH
    Inventors: Bernhard KOHL, Bernd MUELLER, Walter PALOSCH
  • USE OF CICLESONIDE FOR THE TREATMENT OF RESPIRATORY DISEASES
    Publication number: 20130143849
    Abstract: Disclosed herein are novel methods of treating respiratory diseases, and in particular the treatment of asthmatic children.
    Type: Application
    Filed: January 18, 2013
    Publication date: June 6, 2013
    Applicant: NYCOMED GMBH
    Inventor: NYCOMED GMBH
  • Oral Dosage Form Containing A Pde 4 Inhibitor As An Active Ingredient And Polyvinylpyrrolidon As Excipient
    Publication number: 20130131123
    Abstract: An immediate release solid dosage form in tablet or pellet form for oral administration of a PDE 4 inhibitor, comprising a PDE 4 inhibitor that is N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-difluoromethoxybenzamide (roflumilast) or a salt thereof, and one or more suitable pharmaceutical excipients; wherein said dosage form contains 500 ?g of the roflumilast or salt thereof.
    Type: Application
    Filed: January 11, 2013
    Publication date: May 23, 2013
    Applicant: Nycomed GmbH
    Inventors: Rango DIETRICH, Hartmut NEY, Klaus EISTETTER
  • NOVEL SALTS OF 6-HETEROCYCLE SUBSTITUTED HEXAHYDROPHENANTHRIDINE DERIVATIVES
    Publication number: 20130096152
    Abstract: Disclosed herein are salts of 6-heteroaryl substituted hexahydrophenanthridine PDE4 inhibiting compounds, which can be used in the pharmaceutical industry for the production of pharmaceutical compositions.
    Type: Application
    Filed: December 7, 2012
    Publication date: April 18, 2013
    Applicant: NYCOMED GMBH
    Inventor: NYCOMED GMBH
  • CICLESONIDE CONTAINING AQUEOUS PHARMACEUTICAL COMPOSITION
    Publication number: 20130095146
    Abstract: An aqueous pharmaceutical composition which comprises ciclesonide, crystalline cellulose carmellose sodium and hydroxypropylmethylcellulose is provided.
    Type: Application
    Filed: November 29, 2012
    Publication date: April 18, 2013
    Applicant: NYCOMED GmbH
    Inventor: NYCOMED GmbH
  • Ciclesonide containing aqueous pharmaceutical composition
    Patent number: 8383611
    Abstract: The present invention provides an aqueous pharmaceutical composition containing ciclesonide and hydroxypropyl-methylcellulose, wherein the ciclesonide is dispersed in an aqueous medium in the form of solid particles. The composition is able to avoid variations in the concentrations of ciclesonide during production as well as avoid decreases in the recovery rate of ciclesonide.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: February 26, 2013
    Assignee: Nycomed GmbH
    Inventors: Atsuhiro Nagano, Yoshihisa Nishibe, Kazuya Takanashi
  • NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS
    Publication number: 20130045974
    Abstract: Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors, useful in the treatment of psoriasis.
    Type: Application
    Filed: October 26, 2012
    Publication date: February 21, 2013
    Applicant: NYCOMED GMBH
    Inventor: NYCOMED GMBH
  • Use of ciclesonide for the treatment of respiratory diseases
    Patent number: 8371292
    Abstract: The invention relates to new method of treatment of respiratory diseases, in particular the treatment of asthmatic children.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: February 12, 2013
    Assignee: Nycomed GmbH
    Inventors: Thomas Bethke, Renate Engelstaetter, Wilhelm Wurst
  • Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives
    Patent number: 8354535
    Abstract: The invention relates to salts of 6-heteroaryl substituted hexahydrophenanthridine PDE4 inhibiting compounds, which can be used in the pharmaceutical industry for the production of pharmaceutical composition for use, e.g., in treatment of airway disorders.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: January 15, 2013
    Assignee: Nycomed GmbH
    Inventors: Ulrich Kautz, Matthias Webel, Christian Scheufler, Rolf-Peter Hummel
  • PYRAZOLONE DERIVATIVES AS PDE4 INHIBITORS
    Publication number: 20130012544
    Abstract: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: NYCOMED GMBH
    Inventors: Beate SCHMIDT, Christian SCHEUFLER, Jürgen VOLZ, Martin FETH, Rolf-Peter HUMMEL, Armin HATZELMANN, Christof ZITT, Andrea WOHLSEN, Degenhard MARX, Hans-Peter KLEY, Deborah OCKERT, Anke HEUSSR, Johannes A.M. CHRISTIAANS, Geert Jan STERK, Wiro M.P.B. MENGE
  • Guanidinyl-substituted hydroxy-6-phenylphenanthridines
    Patent number: 8329906
    Abstract: The compounds of a certain formula (1), in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as given in the description, are novel effective PDE4 inhibitors.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: December 11, 2012
    Assignee: Nycomed GmbH
    Inventor: Ulrich Kautz
  • 3-thia-10-aza-phenanthrene derivatives
    Patent number: 8324404
    Abstract: The compounds of formula I in which A, R1, R2 and R3 have the meanings as given in the description, are novel effective PDE4 inhibitors.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: December 4, 2012
    Assignee: Nycomed GmbH
    Inventors: Dieter Flockerzi, Jens Christoffers, Anna Christoffers
  • Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors
    Patent number: 8324391
    Abstract: Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: December 4, 2012
    Assignee: Nycomed GmbH
    Inventor: Ulrich Kautz
  • Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors
    Patent number: 8318944
    Abstract: Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: November 27, 2012
    Assignee: Nycomed GmbH
    Inventor: Ulrich Kautz
  • NOVEL PROCESS FOR THE PREPARATION OF ROFLUMILAST
    Publication number: 20120294942
    Abstract: The invention relates to novel processes for the preparation of high-purity roflumilast.
    Type: Application
    Filed: July 12, 2012
    Publication date: November 22, 2012
    Applicant: NYCOMED GMBH
    Inventors: Bernhard KOHL, Bernd MUELLER, Walter PALOSCH
  • 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4,3-c] ISOQUINOLINE DERIVATIVES
    Publication number: 20120289474
    Abstract: The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
    Type: Application
    Filed: December 15, 2010
    Publication date: November 15, 2012
    Applicant: NYCOMED GMBH
    Inventors: Dieter Flockerzi, Thomas Stengel, Alexander Mann, Harald Ohmer, Ulrich Kautz, Steffen Weinbrenner, Stefan Fischer, Christof Zitt, Armin Hatzelmann, Torsten Dunkern, Christian Hesslinger, Thomas Maier, Hermann Tenor, Clemens Braun, Raimund Külzer, Degenhard Marx
  • Pyrazolone derivatives as PDE4 inhibitors
    Patent number: 8304436
    Abstract: The compounds of a certain formula 1, in which R1, R7, R8, R9 and n have the meanings as given in the description, are novel effective inhibitors of the type 4 phosphodiesterase.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: November 6, 2012
    Assignee: Nycomed GmbH
    Inventors: Beate Schmidt, Christian Scheufler, Juergen Volz, Martin Feth, Rolf-Peter Hummel, Armin Hatzelmann, Christof Zitt, Andrea Wohlsen, Degenhard Marx, Hans-Peter Kley, Deborah Ockert, Anke Heuser, Johannes A. M. Christiaans, Geert Jan Sterk, Wiro M. P. B. Menge
  • Stable pharmaceutical products
    Patent number: 8288445
    Abstract: Provided herein is a stable pharmaceutical product comprising a dry powder inhalation device, and a pharmaceutical composition that comprises R,R-Formoterol L-tartrate salt, in particular crystalline R,R-formoterol L-tartrate; and ciclesonide.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: October 16, 2012
    Assignee: Nycomed GmbH
    Inventor: Ruth Wayland
  • STABILIZED PHARMACEUTICAL PRODUCT
    Publication number: 20120247982
    Abstract: Use of an adsorbent and a sealed package (e.g. an overwrap) to protect a pharmaceutical product in a solid state in the presence of a reducing sugar.
    Type: Application
    Filed: April 2, 2012
    Publication date: October 4, 2012
    Applicant: NYCOMED GMBH
    Inventors: Zoe HEATON, David GOODWIN, Iain BREAKWELL