Abstract: A composition comprising: roflumilast having a purity of greater than or equal to 99% by weight, and N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-hydroxybenzamide present (relative to roflumilast) in an amount greater than zero and less than 0.1% by weight.
Type:
Application
Filed:
April 10, 2013
Publication date:
September 5, 2013
Applicant:
NYCOMED GMBH
Inventors:
Bernhard KOHL, Bernd MUELLER, Walter PALOSCH
Abstract: A method for the treatment of chronic obstructive pulmonary disease (COPD), including administering to a patient suffering from COPD, a therapeutically effective amount of roflumilast having a purity of greater than or equal to 99% by weight, and N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-hydroxybenzamide present (relative to roflumilast) in an amount greater than zero and less than 0.1% by weight.
Type:
Application
Filed:
April 10, 2013
Publication date:
August 29, 2013
Applicant:
NYCOMED GMBH
Inventors:
Bernhard KOHL, Bernd MUELLER, Walter PALOSCH
Abstract: An immediate release solid dosage form in tablet or pellet form for oral administration of a PDE 4 inhibitor, comprising a PDE 4 inhibitor that is N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-difluoromethoxybenzamide (roflumilast) or a salt thereof, and one or more suitable pharmaceutical excipients; wherein said dosage form contains 500 ?g of the roflumilast or salt thereof.
Type:
Application
Filed:
January 11, 2013
Publication date:
May 23, 2013
Applicant:
Nycomed GmbH
Inventors:
Rango DIETRICH, Hartmut NEY, Klaus EISTETTER
Abstract: An aqueous pharmaceutical composition which comprises ciclesonide, crystalline cellulose carmellose sodium and hydroxypropylmethylcellulose is provided.
Abstract: Disclosed herein are salts of 6-heteroaryl substituted hexahydrophenanthridine PDE4 inhibiting compounds, which can be used in the pharmaceutical industry for the production of pharmaceutical compositions.
Abstract: The present invention provides an aqueous pharmaceutical composition containing ciclesonide and hydroxypropyl-methylcellulose, wherein the ciclesonide is dispersed in an aqueous medium in the form of solid particles. The composition is able to avoid variations in the concentrations of ciclesonide during production as well as avoid decreases in the recovery rate of ciclesonide.
Abstract: Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors, useful in the treatment of psoriasis.
Abstract: The invention relates to salts of 6-heteroaryl substituted hexahydrophenanthridine PDE4 inhibiting compounds, which can be used in the pharmaceutical industry for the production of pharmaceutical composition for use, e.g., in treatment of airway disorders.
Type:
Grant
Filed:
March 26, 2010
Date of Patent:
January 15, 2013
Assignee:
Nycomed GmbH
Inventors:
Ulrich Kautz, Matthias Webel, Christian Scheufler, Rolf-Peter Hummel
Abstract: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase.
Type:
Application
Filed:
September 14, 2012
Publication date:
January 10, 2013
Applicant:
NYCOMED GMBH
Inventors:
Beate SCHMIDT, Christian SCHEUFLER, Jürgen VOLZ, Martin FETH, Rolf-Peter HUMMEL, Armin HATZELMANN, Christof ZITT, Andrea WOHLSEN, Degenhard MARX, Hans-Peter KLEY, Deborah OCKERT, Anke HEUSSR, Johannes A.M. CHRISTIAANS, Geert Jan STERK, Wiro M.P.B. MENGE
Abstract: The compounds of a certain formula (1), in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as given in the description, are novel effective PDE4 inhibitors.
Abstract: Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors.
Abstract: Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors.
Abstract: The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
Type:
Application
Filed:
December 15, 2010
Publication date:
November 15, 2012
Applicant:
NYCOMED GMBH
Inventors:
Dieter Flockerzi, Thomas Stengel, Alexander Mann, Harald Ohmer, Ulrich Kautz, Steffen Weinbrenner, Stefan Fischer, Christof Zitt, Armin Hatzelmann, Torsten Dunkern, Christian Hesslinger, Thomas Maier, Hermann Tenor, Clemens Braun, Raimund Külzer, Degenhard Marx
Abstract: The compounds of a certain formula 1, in which R1, R7, R8, R9 and n have the meanings as given in the description, are novel effective inhibitors of the type 4 phosphodiesterase.
Type:
Grant
Filed:
May 14, 2008
Date of Patent:
November 6, 2012
Assignee:
Nycomed GmbH
Inventors:
Beate Schmidt, Christian Scheufler, Juergen Volz, Martin Feth, Rolf-Peter Hummel, Armin Hatzelmann, Christof Zitt, Andrea Wohlsen, Degenhard Marx, Hans-Peter Kley, Deborah Ockert, Anke Heuser, Johannes A. M. Christiaans, Geert Jan Sterk, Wiro M. P. B. Menge
Abstract: Provided herein is a stable pharmaceutical product comprising a dry powder inhalation device, and a pharmaceutical composition that comprises R,R-Formoterol L-tartrate salt, in particular crystalline R,R-formoterol L-tartrate; and ciclesonide.
Abstract: Use of an adsorbent and a sealed package (e.g. an overwrap) to protect a pharmaceutical product in a solid state in the presence of a reducing sugar.
Type:
Application
Filed:
April 2, 2012
Publication date:
October 4, 2012
Applicant:
NYCOMED GMBH
Inventors:
Zoe HEATON, David GOODWIN, Iain BREAKWELL