Abstract: A topical formulation of an androstane steroid compound of improved solubility in combinations of the solvents propylene glycol and propylene carbonate.
Abstract: Disclosed are topical formulations comprising an androstane steroid, propylene glycol, and benzyl alcohol in an amount effective to dissolve the androstane steroid compound, wherein the amount of benzyl alcohol is not effective to act as a penetration enhancer. The formulations are useful for the treatment of inflammatory and/or pruritic manifestations of corticosteroid-responsive dermatoses.
Type:
Application
Filed:
December 8, 2006
Publication date:
May 27, 2010
Applicant:
Nycomed US Inc.
Inventors:
Brian Albano, Robert J. Anderson, Joseph A. Check, III, Weldon Crow