Abstract: A topical formulation of an androstane steroid compound of improved solubility in combinations of the solvents propylene glycol and propylene carbonate.

Abstract: Disclosed are topical formulations comprising an androstane steroid, propylene glycol, and benzyl alcohol in an amount effective to dissolve the androstane steroid compound, wherein the amount of benzyl alcohol is not effective to act as a penetration enhancer. The formulations are useful for the treatment of inflammatory and/or pruritic manifestations of corticosteroid-responsive dermatoses.

Abstract: The invention provides aqueous gel compositions comprising metronidazole, benzyl alcohol as a solvent, water, and a polyacrylic acid or cellulosic gelling agent, wherein the benzyl alcohol is present in an amount effective to maintain the physical stability of the aqueous gel composition for at least seven days at 5° C. The invention also provides methods of using and methods of preparing the aqueous gel compositions.

Abstract: A pharmaceutical dispenser including a tube having an open end and a space filled with a composition, and an applicator including a first end removably coupled to the open end of the tube and a longitudinal portion with at least one aperture is described. The dispenser can also include a removable cover extending longitudinally and having a bore surrounding the longitudinal portion of the applicator. The composition may be an anal medication. A single dosage unit of the composition is usually contained in the tube, and the tube, applicator, and cover are disposable after use. Methods of using the dispenser include squeezing the tube, allowing the composition to exit the aperture of the applicator, and applying the composition to a target area.