Patents Assigned to NYMIRUM, INC.
  • Small molecule binding pockets in nucleic acids
    Patent number: 10522239
    Abstract: Described herein is technology for determining the 2-D or 3-D atomic resolution structure of a polynucleotide bound to and/or interacting with another molecule, for example a small molecule. In some aspects of the technology, NMR and isotopic labeling strategies are used. The technology described herein is useful for a plurality of applications including but not limited to drug discovery and chemical biology probe discovery.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: December 31, 2019
    Assignee: Nymirum, Inc.
    Inventors: Andrew Corbet Stelzer, Mitchell Alan McBrairty, Hashim M. Al-Hashimi, Sung-Hun Bae
  • Device and methods for analysis of biomolecule structure, dynamics and activity
    Patent number: 10228337
    Abstract: The present invention provides a method for determining the 3-dimensional or 3-D atomic resolution structure of a biomolecule using chemical shift data obtained from the biomolecule having one or more selectively isotopically labeled biomolecule monomers and interrogation of same using an NMR device. Methods also comprise use of a low-field NMR device and structure determination method to determine the 2-D and 3-D structure of the biomolecule, for example, a polynucleotide.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: March 12, 2019
    Assignee: Nymirum, Inc.
    Inventors: Sung-Hun Bae, Aaron Terrence Frank, Andrew Corbet Stelzer, Hashim M. Al-Hashimi, Joshua Paul Fairbank, Michael Edward Pape
  • Device and Methods for Analysis of Biomolecule Structure, Dynamics and Activity
    Publication number: 20150300968
    Abstract: The present invention provides a method for determining the 3-dimensional or 3-D atomic resolution structure of a biomolecule using chemical shift data obtained from the biomolecule having one or more selectively isotopically labeled biomolecule monomers and interrogation of same using an NMR device. Methods also comprise use of a low-field NMR device and structure determination method to determine the 2-D and 3-D structure of the biomolecule, for example, a polynucleotide.
    Type: Application
    Filed: December 5, 2013
    Publication date: October 22, 2015
    Applicant: NYMIRUM, INC.
    Inventors: SUNG-HUN BAE, AARON TERRENCE FRANK, ANDREW CORBET STELZER, HASHIM M. AL-HASHIMI, JOSHUA PAUL FAIRBANK, MICHAEL EDWARD PAPE