Abstract: The invention is directed towards gene expression characteristic for cancer, in particular brain cancers such as glioblastoma. Compositions, methods and kits encompassing such therein.

Abstract: The present invention provides a method suitable for identifying and producing peptide and peptidomimetic molecules that are capable of producing a recognized phenotypic effect, even in cases where the endogenous peptide is not yet identified and compounds identified thereby. The invention further provides a method for generating related molecules that can be screened to identify a binding agent optimized for therapeutic use and compounds identified thereby. In a preferred embodiment, the invention provides a method for identifying and producing peptide and peptidomimetic molecules that are capable of modulating a phenotypic effect that is produced by the binding of another ligand to the same or a different receptor and compounds identified thereby.

Abstract: The invention is directed towards gene expression characteristic for cancer, in particular brain cancers such as glioblastoma. Compositions, methods and kits encompassing such therein.

Abstract: The present invention relates to an assay for the detection of modified nucleoside levels in a patient. Detection of the modified nucleoside levels in a patient having a disease such as cancer allows for the progression of the disease to be followed and therapeutic regimens to be altered. Such an assay is particularly useful in following the response of cancer patients to chemotherapeutic treatment.

Abstract: The invention is directed towards gene expression characteristic for cancer, in particular brain cancers such as glioblastoma. Compositions, methods and kits encompassing such therein.