Patents Assigned to NZP UK Limited
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Patent number: 11517577Abstract: The invention relates to compounds of general formula (I): wherein R2a, R2b, R3a, R3b, R5, Y and R7 are as defined herein are selective agonists at the FXR receptor and are useful for the treatment or prevention of diseases and conditions including nonalcoholic steatohepatitis (NASH); primary biliary cirrhosis; primary sclerosing cholangitis; biliary atresia; cholestatic liver disease; hepatitis C infection; alcoholic liver disease; fibrosis; and liver damage arising from fibrosis.Type: GrantFiled: July 30, 2019Date of Patent: December 6, 2022Assignees: NZP UK LIMITED, THE UNIVERSITY OF SOUTHAMPTONInventors: Alexander Charles Weymouth-Wilson, Gemma Packer, Bruno Jan Pol Linclau, Dannielle Kydd-Sinclair, Kimberly Ann Watson
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Patent number: 11479577Abstract: The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.Type: GrantFiled: February 26, 2021Date of Patent: October 25, 2022Assignee: NZP UK LimitedInventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans, Ieuan Davies, Carl Otter, Rhys Batchelor
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Publication number: 20220073557Abstract: Compounds of general formula (1): wherein R1, R2 and R3 are as defined herein; are of use in the treatment and prevention of neurodegenerative disorders including Alzheimer's disease and Parkinson's disease.Type: ApplicationFiled: December 20, 2019Publication date: March 10, 2022Applicants: NZP UK LIMITED, THE UNIVERSITY OF SOUTHAMPTONInventors: Alexander Charles Weymouth-Wilson, Bruno Jan Pol Linclau, Gemma Packer, Joseph Watts, Heather Mortiboys, Oliver Bandmann, Christopher Hastings
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Publication number: 20210299148Abstract: The invention relates to compounds of general formula (I): wherein R2a, R2b, R3a, R3b, R5, Y and R7 are as defined herein are selective agonists at the FXR receptor and are useful for the treatment or prevention of diseases and conditions including nonalcoholic steatohepatitis (NASH); primary biliary cirrhosis; primary sclerosing cholangitis; biliary atresia; cholestatic liver disease; hepatitis C infection; alcoholic liver disease; fibrosis; and liver damage arising from fibrosis.Type: ApplicationFiled: July 30, 2019Publication date: September 30, 2021Applicants: NZP UK LIMITED, THE UNIVERSITY OF SOUTHAMPTONInventors: Alexander Charles Weymouth-Wilson, Gemma Packer, Bruno Jan Pol Linclau, Dannielle Kydd-Sinclair, Kimberly Ann Watson
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Publication number: 20210179661Abstract: The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.Type: ApplicationFiled: February 26, 2021Publication date: June 17, 2021Applicant: NZP UK LimitedInventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans, Ieuan Davies, Carl Otter, Rhys Batchelor
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Patent number: 10968250Abstract: The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.Type: GrantFiled: May 18, 2017Date of Patent: April 6, 2021Assignee: NZP UK LimitedInventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans, Ieuan Davies, Carl Otter, Rhys Batchelor
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Patent number: 10766921Abstract: The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein, wherein the epoxidation is conducted using an oxidant and methyltrioxorhenium as a catalyst (MeReO3). The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.Type: GrantFiled: May 18, 2017Date of Patent: September 8, 2020Assignee: NZP UK LimitedInventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans
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Patent number: 10597423Abstract: Disclosed herein is a process for the preparation of a compound of formula (I) and related methods. The compounds of formula (I) are intermediates in the synthesis of synthetic bile acids and its analogues, and the compounds of formula (I) have pharmacological activity. Methods include the synthesizing of these intermediates, and methods of preparing obeticholic acid and obeticholic acid analogues from the prepared compounds.Type: GrantFiled: October 17, 2018Date of Patent: March 24, 2020Assignee: NZP UK LimitedInventors: Alexander Weymouth-Wilson, Zofia Komsta, James Boydell, Laura Wallis, Carl Otter, Ieuan Davies, Rob Clarkson
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Patent number: 10538550Abstract: The invention relates to compounds of formula (I) wherein R1, R2, Y1, R4 and R5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acid derivatives with pharmacological activity. The invention further provides methods related to the synthesizing of these intermediates, and methods of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.Type: GrantFiled: November 19, 2015Date of Patent: January 21, 2020Assignee: NZP UK LimitedInventors: Alexander Weymouth-Wilson, Zofia Komsta, James Boydell, Laura Wallis, Rhys Batchelor, Carl Otter, Ieuan Davies
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Publication number: 20190309012Abstract: The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein, wherein the epoxidation is conducted using an oxidant and methyltrioxorhenium as a catalyst (MeReO3). The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.Type: ApplicationFiled: May 18, 2017Publication date: October 10, 2019Applicant: NZP UK LimitedInventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans
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Publication number: 20190284227Abstract: The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease.Type: ApplicationFiled: May 18, 2017Publication date: September 19, 2019Applicant: NZP UK LimitedInventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans, Ieuan Davies, Carl Otter, Rhys Batchelor
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Patent number: 10301350Abstract: The invention relates to compounds of formula (I) and related methods, wherein R1, R2, Y, R4 and R5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids with pharmacological activity. The invention futher provides intermediated in the systhesis of obeticholic acid and its analogues. The invention also provides methods related to the synthesizing of these intermediates and methods of preparing obeticholic acid and obeticholic acid analogues from the compound of the invention.Type: GrantFiled: November 19, 2015Date of Patent: May 28, 2019Assignee: NZP UK LIMITEDInventors: Alexander Weymouth-Wilson, Zofia Komsta, James Boydell, Carl Otter, Laura Wallis, Rhys Batchelor
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Publication number: 20190153023Abstract: The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein. The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.Type: ApplicationFiled: May 18, 2017Publication date: May 23, 2019Applicant: NZP UK LimitedInventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Ieuan Davies, Jingjing Wang
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Publication number: 20190077827Abstract: The invention relates to compounds of formula (I), wherein R1, R2, Y, R4 and R5b are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids.Type: ApplicationFiled: October 17, 2018Publication date: March 14, 2019Applicant: NZP UK LimitedInventors: Alexander Weymouth-Wilson, Zofia Komsta, James Boydell, Laura Wallis, Carl Otter, Ieuan Davies, Rob Clarkson
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Patent number: 10131688Abstract: The invention relates to compounds of formula (I): wherein R1, R2, Y, R4 and R5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids.Type: GrantFiled: November 19, 2015Date of Patent: November 20, 2018Assignee: NZP UK LimitedInventors: Alexander Weymouth-Wilson, Zofia Komsta, James Boydell, Laura Wallis, Nathan Bartlett, Montserrat Shelbourne