Abstract: A method includes placing a sample of cells, tissue, or an organ into an oxygen imaging system, circulating a humidified gas mixture around the tissue or organ, circulating conditioned air through the oxygen imaging system to maintain a temperature around the sample, and acquiring a three-dimensional oxygen map of the sample. The oxygen map provides a quantitative measure of cell viability and functionality.
Type:
Grant
Filed:
May 28, 2024
Date of Patent:
September 30, 2025
Assignee:
O2M Technologies, LLC
Inventors:
Mrignayani Kotecha, Boris Meerovich Epel, Eliyas Siddiqui, Safa Hameed
Abstract: A method for relaxation time determination includes delivering a series of radio frequency (RF) pulses in a sequence to a specimen having a magnetic resonance spin system. The pulses are separated by equal time intervals and the sequence has a duration comparable or greater than a spin-lattice relaxation time for the spin system. The method includes receiving a response after each RF pulse in the series. The response includes a free induction decay and spin echoes. The method includes generating a series of single point imaging (SPI) images from each response. Each SPI image of the series corresponds to an RF pulse in the series. The method includes converting SPI images to a spin-spin relaxation map and a spin-lattice relaxation map.
Type:
Grant
Filed:
August 2, 2024
Date of Patent:
May 13, 2025
Assignee:
O2M Technologies, LLC
Inventors:
Boris Meerovich Epel, Mrignayani Kotecha
Abstract: A method includes placing a sample of cells, tissue, or an organ into an oxygen imaging system, circulating a humidified gas mixture around the tissue or organ, circulating conditioned air through the oxygen imaging system to maintain a temperature around the sample, and acquiring a three-dimensional oxygen map of the sample. The oxygen map provides a quantitative measure of cell viability and functionality.
Type:
Grant
Filed:
November 10, 2023
Date of Patent:
July 16, 2024
Assignee:
O2M Technologies, LLC
Inventors:
Mrignayani Kotecha, Boris Meerovich Epel, Eliyas Siddiqui, Safa Hameed