Abstract: The present invention relates to self-assembling protein nanoparticles constructed from suitable oligomerization domains and further incorporating the TLR5 binding protein flagellin as an adjuvant molecule. Furthermore, the invention relates to the use of such nanoparticles for vaccination.

Abstract: A brewing system which uses an air pump to evacuate a dispensing line and a method of brewing in which a brewer includes an air pump to provide pressurized air at least at the end of a brew cycle to help evacuate moisture from a dispensing line. The brewing system includes a heated water reservoir which retains heated water for dispensing and a dispense line through which the water is dispensed. A vent is coupled to the reservoir. A controllable air pump communicates with the reservoir to controllably add air to the reservoir to drive water out of the reservoir. The vent is closed when the pump is used to add air to the system to allow for a build-up of air pressure in the reservoir and out through the dispense line. The controllable air pump controllably dispenses air into the upper portion. Both the air vent valve and air pump are controllably coupled to a controller.

Abstract: Provided are inhibitors of sphingosine kinase Type I that are useful in a number of applications, indications and diseases, as well as for monitoring pharmacokinetics and patient management. These compounds are applicable to treating tumors of the central nervous system, such as glioblastoma multiforme (GBM).

Abstract: The present invention relates to methods for treating inflammatory bowel disease and other indications by inhibiting leptin activity.

Abstract: A method for automatically adjusting the setting(s) of a printer having a control circuit in communication with a sensory system and a database. The database is located in a storage medium and the data in the database includes one or more defined parameter settings corresponding to one or more media types. The sensory system is used to obtain a media identifier from media loaded into the printer. The control circuit determines the type of media from the media identifier. The media type is then compared to the database entries and used to retrieve any defined parameter setting(s) corresponding to the media type identified by the media identifier. Instructions to adjust the printer setting(s) according to the defined parameter setting(s) are determined at the control circuit. The control circuit then sends the instructions to the appropriate systems of the printer to adjusted the printer setting(s) according to the defined parameter setting(s).

Abstract: A cutter that is used for dividing a processed product using ultrasound energy. The cutter includes a blade that has least one blade wing, the blade wing narrows at a front side towards a cutting edge, and that is adjoined at a rear side by a blade back. The blade back has a first side surface and a second side surface opposing one another. A mounting surface is provided on the first side surface of the blade back, and on the mounting surface a first end piece of at least one curved, coupling element is welded, and a second end piece of the mounting surface has a connecting member that is connected to an energy converter that supplies ultrasound energy to the blade.

Abstract: Disclosed is a monolayer touch screen, which comprises: a transparent cover glass; a transparent emboss adhesive layer coated on a surface of the transparent cover glass, wherein the transparent emboss adhesive layer has multiple grooves that are located at non-visible region; a metallic mesh layer embedded in the transparent emboss adhesive layer, and the metallic mesh layer are located at a visible region; a hairline finishing layer deposited on the surface of the multiple grooves; and an ink layer coated on the hairline finishing layer. Hairline finishing layer of such monolayer touch screen deposits directly on the surface of multiple grooves of transparent emboss adhesive layer, compared to the traditional touch screen, such monolayer touch screen is thinner and has a hairline finishing effect. Also disclosed is a method for manufacturing the monolayer touch screen.

Abstract: The present invention provides a scanning driver and an organic light-emitting display using the same. The scanning driver comprises a plurality of cascaded structures receiving signals from a first timing clock line (CK1) and a second timing clock line (CK2) with opposite phases, the cascaded structures successively generating output signals (i.e., scanning signals), wherein each of the cascaded structures comprises: a first transistor, connected to a starting signal line or to a scanning output line of a previous cascaded structure; a second transistor, connected to the second timing clock line and to the scanning output line; a third transistor connected to a high-level power supply VGH; a fourth transistor, connected to a low-level power supply VGL and to an output terminal of the third transistor; a fifth transistor, connected to a high-level power supply VGH and to a scanning output line; and a first capacitor, connected between an output terminal of the first transistor and the scanning output line.

Abstract: Provided are methods for labeling target molecules, such as nucleic acids, with fluorescent dye compounds having the formula One method embodiment includes contacting reactive group Z of the fluorescent dye compound with the target molecule such that reactive group Z reacts with the target molecule to form a covalent bond between the group and the target molecule. Another method embodiment includes contacting a fluorescent dye compound that further includes a first member of a binding pair, with a target molecule that includes a second member of the binding pair. Also provided are target molecules labeled with the fluorescent dye compounds.

Abstract: A jig device holding a work piece is used with a milling machine that cuts from the work piece a prosthesis having a surface essentially free of defects. The jig device is inserted repeatedly into the machine in the same predetermined location, even upon inverting the jig device. This maintains the spatial relationship between the jig device and milling so, at start up, they are always in the same exact spatial relationship. The milling machine partially cuts through a first side of the work piece to form in the work piece a cavity having a surface part corresponding to at least a portion of the prosthesis being made. The jig device is then removed from the machine, inverted and reinserted into the machine at the same predetermined location. A support material is placed in the cavity prior to reinserting the jig device. Upon reinserting the jig device, the machine precisely cuts through an opposed side of the work piece to form within the work piece a prosthesis having a surface essentially free of defects.

Abstract: Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.

Abstract: A coated conduit end with a perceivable demarcation quickly and reliably indicates how far conduit is screwed or inserted into a coated conduit fitting to form a conduit system.

Abstract: A tool for removing a jacket from a tube or cable comprises a first through-hole extending through a body of the tool tangent to an anvil. A cut head pivotably mounted to the body includes a depression and a cutting blade mounted to extend into the depression a distance less than the expected thickness of the jacket. The cut head may be raised, then lowered onto a jacketed tube or cable inserted into the first through-hole. Rotation of the tool or the tube or cable scores the jacket circumferentially. A hook blade extends into a second hole in the body at a non-radial orientation to the hole, the hook blade being positioned to engage an inner surface of the jacket when the jacketed tube is inserted into the second hole, and to cut a longitudinal slit in the jacket from a free end of the jacket to the circumferential score.

Abstract: There is provided a method of differentiating an induced pluripotent stem cell (iPSC) into a renal proximal tubular cell (PTC)-like cell. The method comprises culturing an undifferentiated iPSC in a renal epithelial cell culture medium in the presence of one or more extracellular matrix (ECM) molecules, bone morphogenic protein 2 (BMP2) and bone morphogenic protein 7 (BMP7), for a period of from about 8 to about 10 days, under conditions sufficient to induce differentiation of the iPSC into a PTC-like cell. A cell population of differentiated PTC-like cells is also provided, as well as uses and methods of use of the cell population.

Abstract: The present invention relates to methods of genotyping for selecting an animal with a desired trait such as the level monounsaturated fats in muscle tissue, the types and/or ratio of different monounsaturated fats in muscle tissue, marbling, carcass weight, meat quality, speed of finishing, feedlot efficiency and/or consumer preference. In particular the invention relates to methods of selecting an animal with a desired trait by analysing the M-RIP, NT5M and/or TCAP genes for one or more polymorphisms.

Abstract: A bumper structure includes: a bumper reinforcement including: a hollow body portion extending in a vehicle width direction of a vehicle; and an extending portion arranged on one end portion of the hollow body portion in a longitudinal direction of the hollow body portion; and a side member, which is formed to extend in a vehicle front-and-rear direction of the vehicle, and is configured to support one end portion of the bumper reinforcement in a longitudinal direction of the bumper reinforcement. The extending portion includes: a proximal end portion to be sandwiched between the one end portion of the hollow body portion in the longitudinal direction of the hollow body portion and one end portion of the side member in a longitudinal direction of the side member; and a protruding portion formed to extend outward from the proximal end portion in the vehicle width direction. The side member includes a projecting portion protruding outward in the vehicle width direction.