Abstract: Devices and methods for treating obesity are provided. More particularly, intragastric devices and methods of fabricating, deploying, inflating, monitoring, and retrieving the same are provided. The intragastric devices include an intragastric balloon comprising an initial fill gas comprising an inert gas and CO2, a valve system, and a polymeric wall having, under conditions of an in vivo gastric environment, a permeability to CO2 of more than 10 cc/m2/day, such that a rate and an amount of diffusion of CO2 from the in vivo gastric environment into a lumen of the balloon through the polymeric wall is controlled, at least in part, by a concentration of the inert gas and a concentration of CO2 in the initial fill gas, wherein the concentration of CO2 in the initial fill gas is similar to gastric pCO2.
Type:
Grant
Filed:
March 22, 2011
Date of Patent:
June 19, 2012
Assignee:
Obalon Therapeutics, Inc.
Inventors:
Mark C. Brister, Andrew P. Rasdal, Neil R. Drake, Matthew S. Lake, Dubravka Markovic, Amy D. L. VandenBerg, Antonio C. Llevares, Josefina Nider
Abstract: An implant configured for ingestion by a patient. After the implant has been swallowed by the patient and is disposed within the target location, e.g. the patient's stomach, an inflation subcomponent causes the implant to expand from a compact delivery state to an expanded, volume-occupying, deployed state. In the deployed state the implant creates a sensation of satiety in the patient stomach and thereby aids in limiting food intake and obesity. After a predetermined time a deflation subcomponent is actuated and the implant reduces in size so as to allow it to pass through the remainder of the patient's digestive track. The device may further incorporate tracking and visualization subcomponents, as well as pharmaceutical delivery subcomponents.
Type:
Grant
Filed:
October 15, 2009
Date of Patent:
April 24, 2012
Assignee:
Obalon Therapeutics, Inc.
Inventors:
Mark C. Brister, Nelson Quintana, Kaushik A Patel, Neil R. Drake, Antonio C. Llevares, Dubravka Markovic, Andrew P. Rasdal, Amy D. L. VandenBerg
Abstract: An implant configured for ingestion by a patient. After the implant has been swallowed by the patient and is disposed within the target location, e.g. the patient's stomach, an inflation subcomponent causes the implant to expand from a compact delivery state to an expanded, volume-occupying, deployed state. In the deployed state the implant creates a sensation of satiety in the patient stomach and thereby aids in limiting food intake and obesity. After a predetermined time a deflation subcomponent is actuated and the implant reduces in size so as to allow it to pass through the remainder of the patient's digestive track. The device may further incorporate tracking and visualization subcomponents, as well as pharmaceutical delivery subcomponents.
Type:
Grant
Filed:
February 19, 2010
Date of Patent:
December 21, 2010
Assignee:
Obalon Therapeutics, Inc.
Inventors:
Mark C. Brister, Nelson Quintana, Kaushik A. Patel, Neil R. Drake, Antonio C. Llevares, Dubravka Markovic, Andrew P. Rasdal, Amy D. L. VandenBerg
Abstract: An implant configured for ingestion by a patient. After the implant has been swallowed by the patient and is disposed within the target location, e.g. the patient's stomach, an inflation subcomponent causes the implant to expand from a compact delivery state to an expanded, volume-occupying, deployed state. In the deployed state the implant creates a sensation of satiety in the patient stomach and thereby aids in limiting food intake and obesity. After a predetermined time a deflation subcomponent is actuated and the implant reduces in size so as to allow it to pass through the remainder of the patient's digestive track. The device may further incorporate tracking and visualization subcomponents, as well as pharmaceutical delivery subcomponents.
Type:
Application
Filed:
February 19, 2010
Publication date:
June 3, 2010
Applicant:
Obalon Therapeutics, Inc.
Inventors:
Mark C. Brister, Nelson Quintana, Kaushik A. Patel, Neil R. Drake, Antonio C. Llevares, Dubravka Markovic, Andrew P. Rasdal, Amy D.L. VandenBerg
Abstract: An implant configured for ingestion by a patient. After the implant has been swallowed by the patient and is disposed within the target location, e.g. the patient's stomach, an inflation subcomponent causes the implant to expand from a compact delivery state to an expanded, volume-occupying, deployed state. In the deployed state the implant creates a sensation of satiety in the patient stomach and thereby aids in limiting food intake and obesity. After a predetermined time a deflation subcomponent is actuated and the implant reduces in size so as to allow it to pass through the remainder of the patient's digestive track. The device may further incorporate tracking and visualization subcomponents, as well as pharmaceutical delivery subcomponents.
Type:
Application
Filed:
October 15, 2009
Publication date:
April 22, 2010
Applicant:
Obalon Therapeutics, Inc.
Inventors:
Mark C. Brister, Nelson Quintana, Kaushik A. Patel, Neil R. Drake, Antonio C. Llevares, Dubravka Markovic, Andrew P. Rasdal, Amy D.L. VandenBerg
Abstract: Intragastric volume-occupying devices and methods for treating obesity are provided. The devices, which are inflated by carbon dioxide, include an aluminum or silicon oxide barrier layer providing carbon dioxide retention and an alkylene vinyl alcohol polymer layer providing structural integrity in vivo.
Type:
Application
Filed:
October 15, 2009
Publication date:
April 22, 2010
Applicant:
Obalon Therapeutics, Inc.
Inventors:
Mark C. Brister, Kaushik A. Patel, Andrew P. Rasdal, Nelson Quintana, Neil R. Drake, Antonio C. Llevares, Dubravka Markovic, Amy D.L. VandenBerg