Patents Assigned to Ocimum Biosolutions, Inc.
-
Patent number: 7590493Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: GrantFiled: February 17, 2005Date of Patent: September 15, 2009Assignee: Ocimum Biosolutions, Inc.Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
-
Patent number: 7558411Abstract: An automated system and method are provided for analyzing gene expression data obtained from a plurality of microarrays having mismatch (MM) probe pairs and perfect match (PM) probe pairs. Image data for a plurality of scanned microarrays is stored in a database along with a set of microarray parameters which includes one or more image processing metrics for quality control of the microarray and a pass/fail status of the microarray as determined by these metrics. The user can search the database records according to one or more microarray parameters. The image processing metrics include algorithms for removing local background effects from the probe measurements by determining a model for estimated background using PM probe values. Other image processing metrics utilize a modified Robust Multi-array Averaging (RMA) applied to PM probes to assign weights to probes for determining overall quality of a microarray.Type: GrantFiled: August 1, 2003Date of Patent: July 7, 2009Assignee: Ocimum Biosolutions, Inc.Inventors: Michael Elashoff, Chris Alvares, Peter Lauren
-
Patent number: 7469185Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: GrantFiled: February 4, 2003Date of Patent: December 23, 2008Assignee: Ocimum Biosolutions, Inc.Inventors: Donna L. Mendrick, Mark W. Porter, Kory R. Johnson, Brandon Higgs, Arthur L. Castle, Michael Orr, Michael R. Elashoff
-
Patent number: 7447594Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: GrantFiled: January 8, 2003Date of Patent: November 4, 2008Assignee: Ocimum Biosolutions, Inc.Inventors: Donna L. Mendrick, Mark W. Porter, Kory R. Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
-
Patent number: 7428554Abstract: A computer-based system and method are provided for retrieving information from a number of data sources on a computer network containing biological data. The network database is organized in a b-tree configuration having a plurality of sample nodes. Each sample node includes a curated data set of pre-formatted and pre-computed summary biological data obtained from at least one biological sample. The plurality of sample nodes are organized in a hierarchical arrangement according to clinical relevance. A set of attributes is assigned to each sample node to facilitate navigation through the database using a browser accessible through a graphical user interface. The set of attributes including at least one taxonomy designation selected from the group including tissues, diseases, medications and sample parameters. Search results that are produced include automated reports of the summary biological data stored in the sample nodes and custom reports generated using the summary biological data.Type: GrantFiled: May 20, 2004Date of Patent: September 23, 2008Assignee: Ocimum Biosolutions, Inc.Inventors: Carter Coberley, James C. Diggans, Doug Dolginow, Michael Elashoff, Larry Mertz
-
Patent number: 7426441Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: GrantFiled: January 18, 2005Date of Patent: September 16, 2008Assignee: Ocimum Biosolutions, Inc.Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
-
Patent number: 7415358Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: GrantFiled: May 22, 2002Date of Patent: August 19, 2008Assignee: Ocimum Biosolutions, Inc.Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff