Patents Assigned to Oclassen Pharmaceuticals, Inc.
  • Methods for treatment with compositions effective against acyclovir-resistant strains of herpes viruses
    Patent number: 6040298
    Abstract: The present invention relates to pharmaceutical compositions useful for the treatment of subjects suffering from an infection or disease caused by herpes virus strains that are resistant to treatment with acyclovir. In particular, it has been discovered that the low dosage amounts of 1-(2'-deoxy-2'-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil (FIAU) are effective in inhibiting replication of acyclovir-resistant HSV strains. The present invention is also directed to methods of the preparation of pharmaceutical antiviral compositions and to the methods of their use in the treatment of infection or disease.
    Type: Grant
    Filed: December 23, 1992
    Date of Patent: March 21, 2000
    Assignee: Oclassen Pharmaceuticals, Inc.
    Inventors: Dennis W. Adair, Karl M. Johnson, Earl R. Kern
  • Methods for the treatment of infection caused by Hepatitis B virus (HBV)
    Patent number: 5432165
    Abstract: The present invention relates to pharmaceutical compositions useful for the treatment of subjects suffering from an infection or disease caused by the hepatitis B virus (HBV). In particular, it has been discovered that the administration of low dosage amounts of 1-(2'-deoxy-2'-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil (FIAU) to humans chronically infected with HBV is effective to reduce drastically circulating markers associated with HBV. The present invention is also directed to methods of the preparation of pharmaceutical antiviral compositions.
    Type: Grant
    Filed: October 9, 1992
    Date of Patent: July 11, 1995
    Assignee: Oclassen Pharmaceuticals, Inc.
    Inventors: Dennis W. Adair, Kenneth A. Smiles, Dannie H. King
  • Diagnostic kit for the detection of atypical epithelia
    Patent number: 5116328
    Abstract: A kit for use in the visualization of genital warts or other atypical epithelia is disclosed. The kit provides a standardized quantity of acetic acid solution on readily available disposable towelettes sealed in a tear-open pouch for use in colposcopy. Methods for visualizing genital warts utilizing the kit are also disclosed.
    Type: Grant
    Filed: May 1, 1991
    Date of Patent: May 26, 1992
    Assignee: Oclassen Pharmaceuticals, Inc.
    Inventors: Dennie W. Dyer, Dennis W. Adair
  • Podophyllotoxin purification process
    Patent number: 5057616
    Abstract: Podophyllotoxin is recovered from podophyllum resin with improved efficiency by adsorbing impurities out of a solution using a solid adsorbent, preferably alumina. This improvement finds application in an overall process for purifying podophyllotoxin from podophyllum resin in which the podophyllotoxin is first crystallized from the podophyllum resin, the crystals so formed are dissolved and subjected to the solid adsorbent treatment, crystals are then recovered and optionally recrystallized and dried to give the desired product.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: October 15, 1991
    Assignee: Oclassen Pharmaceuticals, Inc.
    Inventors: Rex A. Jennings, Jay F. Stearns