Patents Assigned to Octane Biotech Inc.
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Patent number: 11827902Abstract: The present disclosure provides an automated method of producing genetically modified immune cells, including chimeric antigen receptor T (CAR T) cells, utilizing a fully-enclosed cell engineering system.Type: GrantFiled: May 24, 2022Date of Patent: November 28, 2023Assignees: LONZA WALKERSVILLE, INC., LONZA COLOGNE GMBH, OCTANE BIOTECH INC.Inventors: Yaling Shi, Erika McAfee, Samatha Bandapalle, Ann Siehoff, Timo Gleissner, Joseph O'Connor, Eytan Abraham, Kelly Purpura, Nuala Trainor, Timothy Smith
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Patent number: 11781113Abstract: The present disclosure provides an automated method of producing genetically modified immune cells, including chimeric antigen receptor T (CAR T) cells, utilizing a fully-enclosed cell engineering system.Type: GrantFiled: May 24, 2022Date of Patent: October 10, 2023Assignees: LONZA WALKERSVILLE, INC., LONZA COLOGNE GMBH, OCTANE BIOTECH INC.Inventors: Yaling Shi, Erika McAfee, Samatha Bandapalle, Ann Siehoff, Timo Gleissner, Joseph O'Connor, Eytan Abraham, Kelly Purpura, Nuala Trainor, Timothy Smith
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Patent number: 11714096Abstract: An automated carousel and system configured for translationally moving a plurality of biological production units in unison along a vertical frame while maintaining a precise alignment of each of the biological production units relative to gravity, and simultaneously providing independent dynamic adjustment of the axial orientation of each of the plurality of biological production units relative to gravity. The automated carousel may be adapted for use with a variety of biological production units supporting cell culture and/or tissue engineering systems in various clinical and laboratory settings and provides for ergonomic use thereof.Type: GrantFiled: December 18, 2019Date of Patent: August 1, 2023Assignee: OCTANE BIOTECH INC.Inventors: Timothy Smith, Ian Grant, Guy Oram, Chase McRobie, Raelyn Daniels, Taylor Plant
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Patent number: 11597905Abstract: An automated cell culture and tissue engineering system comprising defined and separate environmental zones provide for increased control and maintenance of the internal environment of the system such that the temperature, air flow and gases surrounding the bioreactor module form one zone that is maintained separately to a second zone formed surrounding the reagent fluid reservoir. The system further comprises means for elimination and/or management of condensation within the second zone of the system.Type: GrantFiled: December 26, 2019Date of Patent: March 7, 2023Assignee: OCTANE BIOTECH INC.Inventors: Guy Oram, Taylor Plant, Ian Grant, Timothy Smith
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Patent number: 11447745Abstract: The present disclosure provides an automated method of producing genetically modified immune cells, including chimeric antigen receptor T (CAR T) cells, utilizing a fully-enclosed cell engineering system.Type: GrantFiled: August 31, 2018Date of Patent: September 20, 2022Assignees: LONZA WALKERSVILLE, INC., LONZA COLOGNE GMBH, OCTANE BIOTECH INC.Inventors: Yaling Shi, Erika McAfee, Samatha Bandapalle, Ann Siehoff, Timo Gleissner, Joseph O'Connor, Eytan Abraham, Kelly Purpura, Nuala Trainor, Timothy Smith
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Patent number: 11371018Abstract: The present disclosure provides an automated method of producing genetically modified immune cells, including chimeric antigen receptor T (CAR T) cells, utilizing a fully-enclosed cell engineering system.Type: GrantFiled: October 30, 2019Date of Patent: June 28, 2022Assignees: OCTANE BIOTECH INC., LONZA WALKERSVILLE, INC., LONZA COLOGNE GMBHInventors: Yaling Shi, Erika McAfee, Samatha Bandapalle, Ann Siehoff, Timo Gleissner, Joseph O'Connor, Eytan Abraham, Kelly Purpura, Nuala Trainor, Timothy Smith
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Patent number: 10844338Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: GrantFiled: July 14, 2020Date of Patent: November 24, 2020Assignee: OCTANE BIOTECH INC.Inventors: Timothy J. N. Smith, Sydney M. Pugh, Martin R. Pecaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
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Patent number: 10723986Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: GrantFiled: December 30, 2016Date of Patent: July 28, 2020Assignee: OCTANE BIOTECH INC.Inventors: Timothy J. N. Smith, Sydney M. Pugh, Martin R. Pecaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
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Patent number: 9783768Abstract: The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module.Type: GrantFiled: April 20, 2011Date of Patent: October 10, 2017Assignee: Octane Biotech, Inc.Inventors: Yves Larcher, Rupert Hagg
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Patent number: 9701932Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: GrantFiled: May 31, 2013Date of Patent: July 11, 2017Assignee: Octane Biotech Inc.Inventors: Timothy J. N. Smith, Sydney M. Pugh, Martin R. Pecaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
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Patent number: 9534195Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors a associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: GrantFiled: May 31, 2013Date of Patent: January 3, 2017Assignee: Octane Biotech Inc.Inventors: Timothy J. N. Smith, Sydney M. Pugh, Martin R. Pecaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
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Patent number: 9499780Abstract: The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accommodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.Type: GrantFiled: May 26, 2005Date of Patent: November 22, 2016Assignee: OCTANE BIOTECH INC.Inventors: Timothy J. N. Smith, Sydney M. Pugh, Lowell Misener, Guy Oram, Rupert Hagg, Roberto Tommasini, Yves Larcher
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Publication number: 20140186937Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: ApplicationFiled: May 31, 2013Publication date: July 3, 2014Applicant: Octane Biotech Inc.Inventors: Timothy J.N. Smith, Sydney M. Pugh, Martin R. Pacaric, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misener
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Publication number: 20130210130Abstract: The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module.Type: ApplicationFiled: April 20, 2011Publication date: August 15, 2013Applicant: Octane Biotech, Inc.Inventors: Yves Larcher, Rupert Hagg
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Patent number: 8492140Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: GrantFiled: April 8, 2003Date of Patent: July 23, 2013Assignee: Octane Biotech Inc.Inventors: Timothy J. N. Smith, Martin R. Pecaric, Sydney J. Pugh, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misner