Abstract: Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.
Type:
Grant
Filed:
March 28, 2018
Date of Patent:
July 12, 2022
Assignee:
Octane Orthobiologics Inc.
Inventors:
Dennis R. Sindrey, Sydney M. Pugh, Timothy J. N. Smith
Abstract: Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.
Type:
Grant
Filed:
September 15, 2015
Date of Patent:
February 12, 2019
Assignee:
Octane Orthobiologics Inc.
Inventors:
Dennis R. Sindrey, Sydney M. Pugh, Timothy J. N. Smith