Abstract: A method of non-invasively measuring the presence, absence, or concentration of one or more analytes in a tissue of a subject includes exposing at least a portion of a tissue of the subject to electromagnetic radiation; obtaining electromagnetic radiation measurement data of electromagnetic radiation from the tissue; using a mathematical transformation to filter or smooth the electromagnetic radiation measurement data; and determining the presence, absence, or concentration of one or more analytes by determining a radiation signature of the filtered or smoothed electromagnetic radiation measurement data; correlating the radiation signature of the filtered or smoothed electromagnetic radiation measurement data with the presence, absence, or concentration of one or more analytes to determine the presence, absence, or concentration of one or more analytes in the subject.

Abstract: Systems and method for tracking measurements from a wireless measurement device are provided. A tracking server is in communication with wireless measurement devices deployed in the field and periodically receives usage reports from the measurement devices to ensure timely measurements by the user and to monitor usage of the measurement devices to ensure compliance. The wireless measurement device is configured to measure one or more analyte levels or concentrations, presence, and/or absence of one or more analytes of the user. The fact of the measurement and the results of the measurement are provided to the tracking server via a wireless communication network. The tracking server stores the information for historical tracking of measurement data usage data. The tracking server may send alerts to a predetermined list of people to notify them when the user is not using the measurement device or when the number of authorized uses needs to be replenished.

Abstract: An apparatus and method of use for enabling a NAM device are provided. The NAM device is configured to authenticate its use each time a measurement is requested. The operation of the NAM device is governed by a refillable media card that tracks a predetermined number of authorized uses. The NAM device confirms that remaining authorized uses are available on the refillable media card. In addition to tracking the number of authorized uses of the NAM device, the media card may also store the results of the measurements for tracking by a tracking server. When the number of authorized uses on the media card is depleted, the media card may be refilled by completing a refill transaction over a wired or wireless communication network. Alternatively, the media card may be refilled at a kiosk station or a new media card may be obtained for use with the NAM device.

Abstract: A method of using a non-invasive analyte reading device to substantially continuously measure the presence, absence, or concentration of one or more analytes in a tissue of a subject includes wearing the non-invasive analyte reading device constantly or for at least the duration of the desired measurement period; and using the non-invasive analyte reading device to non-invasively measure the presence, absence, or concentration of one or more analytes in a tissue of a subject substantially continuously.

Abstract: A combination non-invasive analyte reading and sample analyte reading device for both non-invasively measuring the presence, absence, or concentration of one or more analytes in a tissue of a subject and measuring the presence, absence, or concentration of one or more analytes in a biological sample of a subject includes a device housing; one or more outputs carried by the device housing; one or more inputs carried by the device housing to control operation of the device; a non-invasive analyte reader carried by the device housing and configured to measure the presence, absence, or concentration of one or more analytes in a tissue of a subject; and a sample analyte reader carried by the device housing and configured to measure the presence, absence, or concentration of one or more analytes in a biological sample of a subject.

Abstract: A method of non-invasively measuring the presence, absence or concentration of one or more analytes in an ocular element of a subject, the subject including an eye with an ocular surface and a tear layer, includes exposing at least a portion of the tear layer and/or other ocular elements of the subject to electromagnetic radiation without contact with the ocular surface; detecting electromagnetic radiation reflected from the tear layer and/or other ocular elements without contact with the ocular surface; and determining a radiation signature of the reflected electromagnetic radiation to determine the presence, absence or concentration of the one or more analytes in the tear layer and/or other ocular elements of the subject.

Abstract: A method of non-invasively measuring the presence, absence, or concentration of one or more analytes in a tissue of a subject includes exposing at least a portion of a tissue of the subject to electromagnetic radiation; obtaining a measurement of electromagnetic radiation from the tissue; and determining the presence, absence, or concentration of one or more analytes by determining a radiation signature of the electromagnetic radiation; correlating the radiation signature of the electromagnetic radiation with at least one of concentration, presence, and absence of one or more analytes by utilizing a mathematic transformation such as a transformation based on a 1st or higher derivative of the measurement to determine the presence, absence, or concentration of one or more analytes in the subject.

Abstract: The present invention is related to non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject by measuring electromagnetic radiation signatures from the subject's conjunctiva. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods the conjunctiva of the subject with electromagnetic radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.

Abstract: The present invention is related to optical non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods a body surface of the subject, such as the subject's eye, with radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.

Abstract: The present invention is related to optical non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument measures the level of mid-infrared radiation from the subject's body surface, such as the eye, and determines a specific analyte's concentration based on said analyte's distinctive mid-infrared radiation signature.