Patents Assigned to ODH IP CORP.
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Patent number: 11986818Abstract: This disclosure provides systems and methods for the production of formulations of active pharmaceutical ingredients (APIs). In some embodiments, the disclosure provides an automated medicine formulation system comprising a portable and self-contained API formulating apparatus where the API and excipients are formulated to make a drug product meeting drug quality and safety specifications. The automated formulation system produces liquid formulations including, for example, injectable and intravenous medicines. The systems are capable of producing a plurality of individual sterile injectable doses of drug comprising a specific API and excipient(s), which can be formulated on demand in a GMP and FDA acceptable manner.Type: GrantFiled: March 24, 2023Date of Patent: May 21, 2024Assignee: ODH IP CORP.Inventors: Mahdi Ramezani, Akshaya Nair, Gordon Brezicki, Jonathan Samuel, Alec Nicewick, Griffin Whittredge
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Publication number: 20240109848Abstract: Described herein are methods for the preparation of imidazobenzodiazepines such as midazolam and its intermediates. The processes are capable of using continuous flow chemistry and systems.Type: ApplicationFiled: September 13, 2023Publication date: April 4, 2024Applicant: ODH IP Corp.Inventors: D. Tyler McQuade, Luke Rogers, Josef Maier, Julian Chesterman, Esther Chen, Saad Bux, Brenden Herrera, Loan Truong, Melanie Pachter
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Publication number: 20240091733Abstract: This disclosure provides systems and methods for the on-demand synthesis, separation, purification and formulation of chemicals, and particularly for the on-demand production of pharmaceutical products. More particularly, the disclosure provides continuous-flow on-demand systems, comprising one or more reagent holding/dispensing containers, continuous-flow chemical synthesis modules and/or one or more separation, crystallization, filtration, wash and/or formulation modules, additionally comprising automated detection systems and methods for monitoring reagents, products and processing parameters and automated control systems and methods for controlling processing conditions and parameters.Type: ApplicationFiled: September 5, 2023Publication date: March 21, 2024Applicant: ODH IP Corp.Inventors: Eugene Choi, Kersten Rapp, Greg Hammersmith, Brian Cregger
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Publication number: 20240075448Abstract: Reactor systems, reactors, and removable liners for chemical and biological processes and manufacturing modules and systems using the same, are disclosed. Kits and methods of using the reactor systems and kits as with removable elements are also disclosed.Type: ApplicationFiled: September 5, 2022Publication date: March 7, 2024Applicant: ODH IP CORP.Inventors: Kersten Rapp, David Brancazio
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Publication number: 20240075440Abstract: A combination crystallizer washer filter dryer device and methods of using the device for producing washed and dried product of a reaction are disclosed. The device consolidates the functions of a crystallizer with the filtering, washing, and drying steps to a single vessel, eliminating the need for an additional crystallizer separate from the filter washer dryer device, the transfer of a reaction product or crystallized product from a crystallizer to a subsequent vessel for completing the filtering, washing, and drying process of the solid phase of the slurry.Type: ApplicationFiled: September 5, 2023Publication date: March 7, 2024Applicant: ODH IP Corp.Inventors: Julian Paul Chesterman, Kersten Rapp
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Publication number: 20230302444Abstract: This disclosure provides systems and methods for the production of formulations of active pharmaceutical ingredients (APIs). In some embodiments, the disclosure provides an automated medicine formulation system comprising a portable and self-contained API formulating apparatus where the API and excipients are formulated to make a drug product meeting drug quality and safety specifications. The automated formulation system produces liquid formulations including, for example, injectable and intravenous medicines. The systems are capable of producing a plurality of individual sterile injectable doses of drug comprising a specific API and excipient(s), which can be formulated on demand in a GMP and FDA acceptable manner.Type: ApplicationFiled: March 24, 2023Publication date: September 28, 2023Applicant: ODH IP CORP.Inventors: Mahdi Ramezani, Akshaya Nair, Gordon Brezicki, Jonathan Samuel, Alec Nicewick, Griffin Whittredge
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Publication number: 20230285930Abstract: Modular reactors comprising a chassis, reactor tubing and optionally a cover are disclosed. The chassis comprises a plurality of channels of different lengths into which a length of reactor tubing is placed to create the reactor portion of the flow reactor.Type: ApplicationFiled: March 20, 2023Publication date: September 14, 2023Applicant: ODH IP CORP.Inventor: Madhi Ramezani
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Publication number: 20230149887Abstract: A reactor filter washer dryer (R-FWD) apparatus and methods of using the apparatus for producing washed and dried product of a reaction is disclosed. The R-FWD comprises a vessel defining a process chamber, a filter plate laterally disposed on the vessel base, an agitator assembly, a solids discharge port in the vessel operable to remove the solid fraction of the slurry retained by the filter plate, and a filtrate outlet in the vessel for outflowing the liquid phase of the slurry filtered through the filter plate.Type: ApplicationFiled: September 12, 2022Publication date: May 18, 2023Applicant: ODH IP CORP.Inventor: Luke Rogers
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Patent number: 11623201Abstract: Modular reactors comprising a chassis, reactor tubing and optionally a cover are disclosed. The chassis comprises a plurality of channels of different lengths into which a length of reactor tubing is placed to create the reactor portion of the flow reactor.Type: GrantFiled: March 28, 2022Date of Patent: April 11, 2023Assignee: ODH IP CORP.Inventor: Mahdi Ramezani