Abstract: The present invention is based on the discovery that teeth primordia can be generated using bone marrow cells and that bone marrow cells may be employed to generate teeth without the need for purification and expansion of a population of cells.
Abstract: The present invention is based on the discovery that when a tooth primordium is inserted into a mammalian jaw and tooth formation follows, new alveolar bone around the new tooth forms. The present invention is based on the idea of stimulating new tooth formation via the implantation of tooth primordia at selected places in the jaw (e.g. at four points in the molar regions) to result in the formation of bony protuberances which could facilitate denture retention. The teeth may then be removed from the jaw of the patient to leave the new alveolar bone.
Type:
Grant
Filed:
June 30, 2005
Date of Patent:
March 3, 2009
Assignees:
Odontis Ltd., Intercytek Ltd.
Inventors:
Paul Thomas Sharpe, Michael David Leek, Paul David Kemp, Ewan James Campbell
Abstract: The present invention is based on the discovery that when a tooth primordium is inserted into a mammalian jaw and tooth formation follows, new alveolar bone around the new tooth forms. The present invention is based on the idea of stimulating new tooth formation via the implantation of tooth primordia at selected places in the jaw (e.g. at four points in the molar regions) to result in the formation of bony protuberances which could facilitate denture retention. The teeth may then be removed from the jaw of the patient to leave the new alveolar bone.
Type:
Application
Filed:
June 30, 2005
Publication date:
March 16, 2006
Applicants:
Odontis Ltd., Intercytex, Ltd.
Inventors:
Paul Sharpe, Michael Leek, Paul Kemp, Ewan Campbell