Abstract: The invention provides modified Transferrin (Tf) molecules and conjugates of the Tf molecules with a therapeutic agent. The invention also provides methods of treating cancer wherein the therapeutic agents are chemotherapeutic agents. The modified Tf molecules improve the delivery of the conjugated agent to a target tissue. In some embodiments, the modified Tf molecule has a mutation which decreases the release of bound iron from a Tf complex. The complex can also contain, for instance, a carbonate, oxalate, or other anion to stabilize the Tf iron complex.
Type:
Application
Filed:
December 6, 2010
Publication date:
November 24, 2011
Applicants:
The Regents of the University of California Office of Technology Transfer, Office of Technology Transfer, University of Vermont
Inventors:
Daniel T. Kamei, Bert J. Lao, Wen-Lin P. Tsai, Foad Mashayekhi, Edward A. Pham, Anne B. Mason