Patents Assigned to Office of Technology Transfer
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Publication number: 20140015749Abstract: “A computer-implemented method and system (“Legion”) for capturing and outsourcing an existing graphical user interface (“GUI”) of an application to a crowd for their collaborative real-time control using an input device are provided. A crowd refers to a dynamic pool of one or a plurality of anonymous worker of varying skill level and/or reliability. The pool is dynamic because workers are able to come and go at their leisure and no specific worker can be relied upon to be available at a given time or to continue working on a job for a specific amount of time. Mediation strategies for integrating the input of multiple crowd workers in real-time is also provided.Type: ApplicationFiled: July 10, 2012Publication date: January 16, 2014Applicant: University of Rochester, Office of Technology TransferInventors: Jeffrey Philip BIGHAM, Walter Stephen LASECKI, Kyle Ian MURRAY, Samuel Christopher WHITE
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Publication number: 20140010802Abstract: Systems, methods, and computer readable media for diagnosing or characterizing a genetic predisposition to develop cancer, including cancers of the BAP1 cancer syndrome, are provided. Nucleic acids comprising a germline nucleic acid sequence encoding the BRCA1 associated protein 1 (BAP1) are sequenced or probed to determine if the nucleic acid sequence includes alterations that predispose a subject to develop cancer.Type: ApplicationFiled: August 19, 2013Publication date: January 9, 2014Applicants: University of Hawaii, Office of Technology Transfer and Economic Development, Institute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center ("Fox Chase CInventors: Joseph R. Testa, Michele Carbone, Mitchell Cheung, Jianming Pei
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Patent number: 8518647Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 14, 2011Date of Patent: August 27, 2013Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
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Publication number: 20130211049Abstract: The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti-T cell immunotoxin fusion proteins. Also provided are immunotoxins that can be ex-pressed in bacterial, yeast, or mammalian cells. The invention also provides means for expression of the immunotoxin fusion protein. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.Type: ApplicationFiled: April 10, 2012Publication date: August 15, 2013Applicants: Office of Technology TransferInventors: David M. Neville, JR., Jerry T. Thompson, Huaizhong Hu, Jung-Hee Woo, Shenglin Ma, Jonathan Mark Hexham, Mary Ellen Digan
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Publication number: 20130203736Abstract: The present invention relates to novel compositions comprising an agonist and an antagonist, in certain ratios which allow for the onset of agonist action followed quickly by alleviation by antagonist action, and methods of use in personal defense and law enforcement.Type: ApplicationFiled: March 11, 2011Publication date: August 8, 2013Applicant: USDHHS Office of Technology TransferInventors: Peter M. Blumberg, Larry V. Pearce
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Publication number: 20130188409Abstract: An energy-efficient CAM architecture provides increased speed of searching, reduced power consumption, or a tuned combination of increased speed of searching and reduced power consumption. The CAM comprises a plurality of CAM banks, a plurality of Bloom filters, each Bloom filter associated with a content addressable memory bank, each Bloom filter recording elements inserted into an associated content addressable memory bank, wherein the size of each Bloom filter is configured to reduce energy or power consumption of the content addressable memory apparatus. The size of each Bloom filter may be configured to reduce energy or power consumption of the content addressable memory apparatus.Type: ApplicationFiled: January 22, 2013Publication date: July 25, 2013Applicant: University o Rochester, Office of Technology TransferInventor: University of Rochester, Office of Technology Transfer
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Patent number: 8487249Abstract: The apparatus introduces a second adjustable resonant point in a QMS at a frequency that is close to a multiple of the fundamental frequency by adjusting driving point impedance characteristics of the QMS. The apparatus measures the first and second resonant point of the QMS to account for changes in the operational characteristics of the QMS.Type: GrantFiled: December 14, 2011Date of Patent: July 16, 2013Assignee: The Regents of the University of Michigan Office of Technology TransferInventors: Daniel Gershman, Bruce Block, Martin Rubin, Thomas Zurbuchen
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Publication number: 20130162344Abstract: A technique for implementing an clock tree distribution network having a clock buffer and a plurality of LC tanks that each take into \consideration local capacitance distributions and conductor resistances. An AC-based sizing formulation is applied to the buffer and to the LC tanks so as to reduce the total buffer area. The technique is iterative and can be fully automated while also reducing clock distribution power consumption.Type: ApplicationFiled: June 23, 2012Publication date: June 27, 2013Applicant: The Regents of the University of California Office of Technology TransferInventor: Matthew Guthaus
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Publication number: 20130156781Abstract: The present invention provides antibodies and antibody fragments that specifically recognize and agonize the death receptor 4 (DR4). Also provided in the invention are polynucleotides and vectors that encode such molecules and host cells that harbor the polynucleotides or vectors.Type: ApplicationFiled: June 16, 2011Publication date: June 20, 2013Applicant: The Govt. of the United States of America H.H.N.I. H., Office of Technology TransferInventors: Dimiter Dimitrov, Yang Feng
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Publication number: 20130154727Abstract: A method of implementing a VLSI clock network is implemented. That method includes a step of generating an initial VLSI clock grid for incorporation on a silicon die. An input grid buffer is then sized and implemented for the VLSI clock grid. LC tanks are then placed and sized in the VLSI clock grid to implement a resonant tank clock grid and the input grid buffer is resized. A check of the resonant tank design criteria is then made. If the design criteria are met the resonant VLSI clock grid with its LC tanks is implemented. If not, another attempt at implementing a suitable LC tanks placement and sizing is made. The process iterates until a VLSI clock grid that meets the design criteria is obtained.Type: ApplicationFiled: June 23, 2012Publication date: June 20, 2013Applicant: The Regents of the University of California Office of Technology TransferInventor: Matthew Guthaus
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Patent number: 8465917Abstract: The invention provides a method of determining an HCC subtype in a subject comprising a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. The invention further provides methods of detecting HCC stem cells in a sample. Additionally, the invention provides methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.Type: GrantFiled: June 9, 2008Date of Patent: June 18, 2013Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institutes of Health, Office of Technology TransferInventors: Xin Wei Wang, Junfang Ji, Taro Yamashita, Carlo M. Croce
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Publication number: 20130123340Abstract: Disclosed herein are compositions and methods for the treatment and/or prevention of pathological conditions associated with ischemia/reperfusion injury and/or hypoxic injury of myocardial cell or tissue.Type: ApplicationFiled: May 11, 2010Publication date: May 16, 2013Applicants: PEKING UNIVERSITY, OFFICE OF TECHNOLOGY TRANSFER, UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEYInventors: Jianjie Ma, Noah Weisleder, Yan Zhang, Chunmei Cao, Rui-Ping Xiao
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Patent number: 8426154Abstract: Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer.Type: GrantFiled: April 8, 2010Date of Patent: April 23, 2013Assignees: SpiderTech, a Division of Stoecker & Associates, a Subsidiary of The Dermatology Center, LLC., The Regents of the University of Michigan, Office of Technology Transfer, The Curators of the University of Missouri, University Hall, The United States of America as Represented by the Secretary of the Air Force, Directorate of Intellectual Property LawInventors: William V. Stoecker, Hernan F. Gomez, Jonathan A. Green, David L. McGlasson
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Patent number: 8399518Abstract: Methods and compositions are disclosed for stimulating weight loss and/or lowering triglyceride levels in an individual mammal in need thereof. In an exemplary method, a pharmaceutical composition comprising a therapeutically effective amount of DITPA, and optionally one or more lipid-reducing agents, is administered to an individual mammal to stimulate weight loss, and/or reduce levels of triglyceride and/or lipoprotein in the mammal.Type: GrantFiled: February 27, 2008Date of Patent: March 19, 2013Assignees: University of Arizona Office of Technology Transfer, The United States of America as Represented by the Department of Veterans AffairsInventors: Eugene Morkin, Louis R. Bucalo, Steven Goldman
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Publication number: 20130065863Abstract: Disclosed is a compound of the formula (I) or a pharmaceutically acceptable salt thereof: (I) in which R1, R2, R3, and R4 are defined herein and pharmaceutical compositions thereof. Further provided is a method of treating various disorders, such as a disorder selected from the group consisting of a cardiovascular disorder, cancer, chronic pain, alcohol dependence, and inflammation in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt of formula (I).Type: ApplicationFiled: March 18, 2011Publication date: March 14, 2013Applicants: The Arizona Board of Regents, on behalf of the University of Arizona, Office of Technology Transfer, NIHInventors: Katrina M. Miranda, David A. Wink, Debra J. Salmon, Debashree Basudhar, Larry K. Keefer, Joseph E. Saavedra, Daniela Andrei
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Publication number: 20130065780Abstract: Label-free, multiplexed DNA assay using fluorescent conjugated polymers as a detection probe to illustrate hybridization on metallic striped nanorods are disclosed. Different DNA capture probes are encoded by the different reflectivity of Au and Ag stripe patterns. The integration of fluorescent conjugated polymers as detection moieties with metallic striped nanorods for multiplexed detection of clinically important cancer marker proteins in an immunoassay format is also provided.Type: ApplicationFiled: February 14, 2011Publication date: March 14, 2013Applicant: North Carolina State University Office of Technology TransferInventors: Lin He, Weiming Zheng
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Publication number: 20130029293Abstract: Disclosed are various embodiments for echoperiodontal imaging. In one embodiment, a system includes a transducer configured to transmit a series of ultrasonic signals at a plurality of corresponding locations along soft tissue of a jaw and receive a plurality of echo signals; and an imaging system controller configured to obtain a plurality of echo signal data of the soft tissue and a plurality of transducer positions, where each echo signal data corresponds to one of the plurality of transducer position.Type: ApplicationFiled: July 27, 2012Publication date: January 31, 2013Applicant: West Virginia University Research Corporation WVU Office of Technology TransferInventors: Osama M. Mukdadi, Ahmed M. Mahmoud, Eros S. Chaves, Richard Crout
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Patent number: 8362760Abstract: Disclosed are various embodiments of methods and systems related to stimulus responsive nanoparticles. In one embodiment includes a stimulus responsive nanoparticle system, the system includes a first electrode, a second electrode, and a plurality of elongated electro-responsive nanoparticles dispersed between the first and second electrodes, the plurality of electro-responsive nanorods configured to respond to an electric field established between the first and second electrodes.Type: GrantFiled: February 19, 2009Date of Patent: January 29, 2013Assignee: West Virginia University Research Corporation, WVU Office of Technology TransferInventors: Darren Robert Cairns, Wade W. Huebsch, Konstantinos A. Sierros, Matthew S. Shafran
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Patent number: 8349568Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 14, 2011Date of Patent: January 8, 2013Assignees: The Ohio State University Research Foundation, The United States of America, as Represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
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Patent number: 8343725Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 15, 2011Date of Patent: January 1, 2013Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter