Patents Assigned to Ohgen Research Laboratories, Ltd.
  • Geranyl compounds
    Patent number: 7579376
    Abstract: This invention provides compounds having excellent antitumor activity, which are represented by the following formulae in which R1, R2, R3, m, n and R4 have the significations as given in the specification.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: August 25, 2009
    Assignee: Ohgen Research Laboratories, Ltd.
    Inventor: Kiyoshi Akiyama
  • Mevalonic acid derivatives
    Patent number: 7553820
    Abstract: This invention provides compounds having excellent antitumor activity, which are represented by the following formulae in which R1, R2, R3, m, n and R4 have the significations as given in the specification.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: June 30, 2009
    Assignee: Ohgen Research Laboratories, Ltd.
    Inventor: Kiyoshi Akiyama
  • Geranyl compounds
    Patent number: 7507765
    Abstract: This invention provides compounds having excellent antitumor activity, which are represented by the following formulae in which R1, R2, R3, m, n and R4 have the significations as given in the specification.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: March 24, 2009
    Assignee: Ohgen Research Laboratories, Ltd.
    Inventor: Kiyoshi Akiyama
  • Geranyl compounds
    Patent number: 7125852
    Abstract: This invention provides compounds having excellent antitumor activity, which are represented by the following formulae in which R1, R2, R3, m, n and R4 have the significations as given in the specification.
    Type: Grant
    Filed: December 26, 2002
    Date of Patent: October 24, 2006
    Assignee: Ohgen Research Laboratories, Ltd.
    Inventor: Kiyoshi Akiyama
  • N-methyldeacetylcolchiceinamide derivatives
    Patent number: 5672757
    Abstract: N-methyldeacetylcolchiceinamide derivatives represented by the formula ##STR1## wherein R denotes a residue obtained by removing COOH from a C.sub.3 -C.sub.7 sugar carboxylic acid, and hydroxyl groups present in the residue may properly be protected with a protecting group for a hydroxyl group.The N-methyldeacetylcolchiceinamide derivatives have less toxicity and strong effect for inhibiting proliferation of tumor cells, and are expected to be used as a carcinostatic.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: September 30, 1997
    Assignee: Ohgen Research Laboratories, Ltd.
    Inventor: Kiyoshi Akiyama
  • N-methyldeacetylcolchiceinamide derivatives
    Patent number: 5523320
    Abstract: N-methyldeacetylcolchiceinamide derivatives represented by the formula ##STR1## wherein R denotes a residue obtained by removing COOH from a C.sub.3 -C.sub.7 sugar carboxylic acid, and hydroxyl groups present in the residue may properly be protected with a protecting group for a hydroxyl group.The N-methyldeacetylcolchiceinamide derivatives have less toxicity and strong effect for inhibiting proliferation of tumor cells, and are expected to be used as a carcinostatic.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: June 4, 1996
    Assignee: Ohgen Research Laboratories, Ltd.
    Inventor: Kiyoshi Akiyama
  • 5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[alpha]heptalene derivative and pharmaceutical use
    Patent number: 5326786
    Abstract: Compounds represented by the formula ##STR1## wherein R.sub.1 and R.sub.2 each represent a hydrogen atom or a protective group for a hydroxyl group, or R.sub.1 and R.sub.2 combine to represent a protective group for hydroxyl groups, andR.sub.3 represents CH.sub.3 O-- or CH.sub.3 NH--.These compounds exhibit a strong effect to inhibit proliferation of cancer cells and are expected to be used as a carcinostatic agent.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: July 5, 1994
    Assignee: Ohgen Research Laboratories Ltd.
    Inventor: Kiyoshi Akiyama
  • Deacetylcolchicine derivatives
    Patent number: 5220002
    Abstract: Deacetylcolchicine derivatives represented by the formula ##STR1## wherein R denotes a residue obtained by removing COOH from a C.sub.3 -C.sub.7 sugar carboxylic acid, and a hydroxyl group present in the residue may properly be protected with a protecting group of the hydroxyl group.Said deacetylcolchicine derivatives have less toxicity and strong effect for inhibiting proliferation of tumor cells, and are expected to be used as an antitumor agent.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: June 15, 1993
    Assignee: Ohgen Research Laboratories, Ltd.
    Inventor: Kiyoshi Akiyama