Abstract: A method may comprise: exposing a substituted chromone dissolved in a solvent to a sample; taking a fluorescence measurement of the sample after exposure to the substituted chromone; and determining a presence or absence of one or more ions in the sample, a concentration of the one or more ions in the sample, or both based on the fluorescence measurement.
Abstract: A method may comprise: exposing a substituted chromone dissolved in a solvent to a sample; taking a fluorescence measurement of the sample after exposure to the substituted chromone; and determining a presence or absence of one or more ions in the sample, a concentration of the one or more ions in the sample, or both based on the fluorescence measurement.
Abstract: The increase in antibacterial resistance has created the demand for new antibiotics. The present invention relates to a more potent antibiotic that targets the enzyme glutamate racemase from known glutamate racemase inhibitors. Glutamate racemase catalyses the interconversion of L-glutamate to D-glutamate, making D-glutamate available, which is required for bacterial peptidoglycan biosynthesis. Knockout mutations have shown glutamate racemase to be necessary for bacterial cell survival and, before the present invention, no antibiotic on the market targeted this enzyme. The present invention relates to new, ligand based glutamate racemase inhibitors, developed using software to extract a pharmacophore model from a group of known glutamate racemase inhibitors. Forty-seven (47) known inhibitors were collected from the literature and several pharmacophore models were extracted therefrom.
Type:
Grant
Filed:
October 15, 2009
Date of Patent:
August 7, 2012
Assignee:
Ohio Northern University
Inventors:
Tarek M. Mahfouz, Kyle W. Skidmore, Amy Stockert, Corey Scherer
Abstract: An automatic alignment vise capable of automatically precisely positioning a workpiece to be machined. The vise can provide precise three dimensional positioning in response to data signals provided by a robotic device, a vertical milling machine or other machining device. The vise allows precise machining of all faces of the workpiece.
Type:
Grant
Filed:
April 26, 1994
Date of Patent:
February 6, 1996
Assignee:
Ohio Northern University
Inventors:
Kris Vollrath, Shane Bendele, Chris Recker, Chad Weaver, Eric McWhorter, Jamie Cree, Adam Park, Kirby Harder, Sean Jeric, Michael Vaughn, Charles A. Shearrow