Abstract: The innovation disclosed and claimed herein, in aspects thereof, comprises systems and methods of identifying AUs and emotion categories in images. The systems and methods utilized a set of images that include facial images of people. The systems and methods analyze the facial images to determine AUs and facial color due to facial blood flow variations that are indicative of an emotion category. In aspects, the analysis can include Gabor transforms to determine the AUs, AU intensities and emotion categories. In other aspects, the systems and method can include color variance analysis to determine the AUs, AU intensities and emotion categories. In further aspects, the analysis can include deep neural networks that are trained to determine the AUs, emotion categories and their intensities.

Abstract: According to one aspect, the present disclosure provides a system for manufacturing transition structures including fiber threads embedded within a metal component. The system may include a supply of base sheet metal. The system may include a conveyor supported on a plurality of rollers and configured to move the base sheet metal in a production direction. The system may include a plurality of stages arranged in the production direction. Each stage may include a channel forming device configured to form a channel in the base sheet metal, a fiber inserting device configured to insert a portion of a fiber material into the channel, and one or more ultrasonic welders configured to consolidate a layer of metal foil over the fiber. The disclosure includes methods of using the system to produce transition structures and reinforced components.

Abstract: Compositions for and methods of treating liver injury are provided. Said compositions comprise MG53 or express MG53. Said compositions can be used for treating chronic or acute injured liver tissue and can be administered systemically, locally, or both.

Abstract: A variable density Cartesian sampling method that allows retrospective adjustment of temporal resolution, providing added flexibility for real-time applications where optimal temporal resolution may not be known in advance. The methods provide for a computationally efficient sampling methods where a first step includes producing a uniformly random sampling pattern using a golden ratio on a grid, and the second step is applying a nonlinear stretching operation to create a variable density sampling pattern. Diagnostic quality images may be recovered at different temporal resolutions.

Abstract: The present technology is directed to fluorinated alkylsulfonamide electrolyte salts with high solubility, conductivity, and electrochemical stability as well as batteries incorporating fluorinated alkylsulfonamide salts. In any aspect and/or embodiment herein of the present technology, the battery may include a separator disposed between the cathode and the anode. The separator may be a porous paper, porous ceramic, or porous polymer separator.

Abstract: Aspects of the disclosure provide a method including determining a measurement configuration for one or more piezoelectric devices in an electronic apparatus. The electronic apparatus includes an electronic device mounted on a substrate block using a bonding layer. The one or more piezoelectric devices including a first subset and a second subset are attached to one of the electronic device and the bonding layer. The method includes performing, based on the measurement configuration, a defect measurement on the electronic apparatus by causing the first subset to transmit and the second subset to receive one or more acoustic signals. The method includes determining whether at least one mechanical defect is located in at least one of (i) the bonding layer, (ii) the electronic device, (iii) the substrate block, (iv) interfaces of the electronic device, the bonding layer, and the substrate block based on the received one or more acoustic signals.

Abstract: A transcatheter prosthetic heart valve includes a stent frame and at least one sheet of leaflet material formed in to a tube, which includes a lower portion disposed on an exterior of the stent frame and an upper edge portion disposed within the stent frame. The upper edge portion includes at least a portion configured to wrap around a first portion of the top edge of the stent frame and fold towards an exterior of the stent frame. The upper edge portion also includes at least another portion configured to weave through the stent frame and fold towards the interior of the stent frame.

Abstract: An example method for connectorizing a superconducting cable is described herein. The method can include depositing an oxide layer on a surface of a superconducting cable, electroplating a metal layer on the surface of the superconducting cable, and soldering a connector to the metal layer coated on the surface of the superconducting cable. The oxide layer allows the metal layer to adhere to the surface of the superconducting cable.

Abstract: An apparatus, method and system for resolving an n-number of photons from an optical source multiphoton event, the apparatus includes a cryostat includes a single-pixel superconducting nanowire single-photon detector (SNSPD) configured to receive an optical signal and therefrom produce a corresponding electrical signal, and a current bias source configured to supply a bias current to the SNSPD.

Abstract: Disclosed is a general, reversible bicyclization strategy to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fused with a short cell-penetrating motif and converted into a conformationally constrained bicyclic structure through the formation of a pair of disulfide bonds. The resulting bicyclic peptide has greatly enhanced proteolytic stability as well as cell-permeability. Once inside the cell, the disulfide bonds are reduced to produce a linear, biologically active peptide. This strategy was applied to generate a cell-permeable bicyclic peptidyl inhibitor against the NEMO-IKK interaction.

Abstract: Systems, methods, and computer program products for controlling use of sensitive data. A heartbeat signal conveying a context identifier is transmitted into areas where access to sensitive data is granted to authorized users. In response to receiving a request to access the sensitive data, access may be granted if the context identifier in the request matches the context identifier in the heartbeat and denied otherwise. If the requestor has exceeded an access threshold, access may be granted at a reduced rate. This reduced rate may be achieved by reducing a rate at which encryption keys are provided to the requestor. An access control layer positioned between an application layer and a communication layer allows the application layer to use plaintext of the sensitive data while protecting the sensitive data as ciphertext in the communication layer.

Abstract: Methods for automated calibration and adaption of a gearshift controller (39) are disclosed. In one aspect, the method automates calibration a gearshift controller (39) for controlling a sequence of gearshifts in either a stepped automatic transmission equipped with at least one speed sensor mounted on a dynamometer (42) or an automotive vehicle mounted on a dynamometer (42), where the dynamometer (42) is electronically controlled by a dynamometer controller (43). Each gearshift in the sequence includes a first phase, a second phase, . . . and an Nth phase. The gearshift controller (39) includes (initial values of) a first phase control parameters set, a second phase control parameters set, . . . and an Nth phase control parameters set for each gearshift in the sequence that are updated using a first phase learning controller, a second phase learning controller, . . . and an N*11 phase learning controller respectively.

Abstract: Disclosed herein is a Chlamydia-activated B cell (CAB) platform. Also disclosed is a method of enhancing a population of B cells, comprising exposing said B cells to Chlamydia spp. under conditions suitable to enhance the population of B cells, such that expansion and differentiation of said B cells takes place, and said B cells are exposed or crosslinked to an antigen. Also disclosed are methods of producing said CABs, and treating a subject in need thereof with said CABs.

Abstract: Compositions and methods for the treatment of Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), also known as Juvenile Batten Disease, are provided herein. In certain embodiments the compositions include but are not limited to adeno-associated viral (AAV) constructs, including self-complementary adeno-associated viral (sc-AAV) constructs, that express the human gene CLN3 (or a CLN3 cDNA).

Abstract: Articles including repellent surfaces and methods of making and using these articles are disclosed. The repellant surface can comprise a polymer having a roughened surface and a fluorinated silane and a lubricating liquid deposited on the roughened surface. The repellent surface, and by extension the articles described herein, can exhibit superomniphobic properties. The methods for producing the repellant surface can comprise dissolving a polymer in a solvent to produce a polymer solution and optionally adding a non-solvent to the polymer solution to produce a casting mixture. The polymer solution or casting mixture can be deposited on a surface of a substrate and the solvent and/or the non-solvent evaporated to provide a coated-substrate having a roughened surface. A functional layer comprising a fluorinated silane followed by a lubricating liquid can be deposited on the roughened surface to form the repellant surface.

Abstract: A non-invasive, continuous, and direct system for detecting the presence of malaria parasites that exploits the paramagnetic properties of hemozoin in red blood cells. An electromagnetic probe (EM probe) is comprised of a dual coaxial coil used to detect iron oxide particles by using sensitive lock-in amplification of detector voltage or phase shift.

Abstract: Disclosed herein are three-dimensional cage molecules, wherein the cage molecule is composed of RNA. Also disclosed is a composition including the three-dimensional cage molecule, as well as a pharmaceutical composition containing the three-dimensional cage molecule. Also disclosed herein are methods of administering a cage molecule, composition, or formulation thereof to a subject in need thereof.

Abstract: Disclosed are systems and methods for clinical trial assessment of skin disease treatment. The disclosure includes obtaining a series of digital images over a period of time, wherein each digital image includes an affected area of the subject; identifying characteristic morphologies and lesions in the affected area of the subject in each of the digital images; classifying each of the detected and segmented morphologies and lesions into one or more identified categories for each of the digital images; assigning a global score to each of the digital images based on a count of the detected and segmented characteristic morphologies and lesions in each of the one or more identified categories; analyzing the global scores of each of the digital images; and making an assessment of the clinical trial based on the analysis of the global scores of each of the digital images.

Abstract: Provided herein are devices and methods for topically and controllably delivering cargo across or into biological tissues, particularly the skin. These devices permit delivery of cargo to deeper cell layers of a tissue. These devices include microstructure arrays comprising nanochannels. Also disclosed is a device comprising a one or more microstructure arrays encased in a frame.

Abstract: Systems and methods are described herein for real-time data processing and for emergency planning. Scenario test data may be collected in real-time based on monitoring local or regional data to ascertain any anomaly phenomenon that may indicate an imminent danger or of concern. A computer-implemented method may include filtering a plurality of different test scenarios to identify a sub-set of test scenarios from the plurality of different test scenarios that may have similar behavior characteristics. A sub-set of test scenarios is provided to a trained neural network to identify one or more sub-set of test scenarios. The one or more identified sub-set of test scenarios may correspond to one or more anomaly test scenarios from the sub-set of test scenarios that is most likely to lead to an undesirable outcome. The neural network may be one of: a conventional neural network and a modular neural network.