Patents Assigned to Ohio University Edison Animal Biotechnology Institute
  • Method for eliciting an immune response using a gene expression system that co-delivers an RNA polymerase with DNA
    Patent number: 5846949
    Abstract: The present invention relates to a gene expression system in eukaryotic cells. In particular, it relates to a self-initiating and self-sustaining gene expression system utilizing an RNA polymerase prebound to a DNA construct before the introduction of the complex into cells. This system is capable of functioning in the cell cytoplasm without integration into the genome of host cells, and does not require host cell factors for initiation and maintenance of gene expression. Therefore, the invention has a wide range of applications in in vitro and in vivo gene expression, including gene therapy in resting cells.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: December 8, 1998
    Assignee: Ohio University Edison Animal Biotechnology Institute
    Inventors: Thomas E. Wagner, Xiaozhuo Chen, Yunsheng Li
  • DNA polymerase gene expression system utilizing an RNA polymerase co-delivered with the gene expression vector system
    Patent number: 5591601
    Abstract: The present invention relates to a gene expression system in eukaryotic cells. In particular, it relates to a self-initiating and self-sustaining gene expression system utilizing an RNA polymerase prebound to a DNA construct before the introduction of the complex into cells. This system is capable of functioning in the cell cytoplasm without integration into the genome of host cells, and does not require host cell factors for initiation and maintenance of gene expression. Therefore, the invention has a wide range of applications in in vitro and in vivo gene expression, including gene therapy in resting cells.
    Type: Grant
    Filed: May 14, 1993
    Date of Patent: January 7, 1997
    Assignee: Ohio University Edison Animal Biotechnology Institute
    Inventors: Thomas E. Wagner, Xiaozhuo Chen, Yunsheng Li