Abstract: The object is to provide a method of manufacturing a fraction containing nobiletin and tangeretin at high concentrations, which is excellent in terms of safety, economic efficiency, and the potential for industrialization. The method includes (1-1) a step of treating citrus fruit with hot water to obtain a hot water-treated product; (1-2) a step of drying the hot water-treated product to obtain a dried product; (1-3) a step of treating the dried product with a solvent capable of dissolving nobiletin and tangeretin to obtain a nobiletin and tangeretin solution; (3) a step of concentrating and/or drying the nobiletin and tangeretin solution to obtain a nobiletin and tangeretin concentrate; and (4) a step of treating the nobiletin and tangeretin concentrate with a dilute alkali to obtain a composition containing nobiletin and tangeretin as an insoluble component, and by a composition containing nobiletin and tangeretin at high concentrations manufactured by the method.
Type:
Grant
Filed:
August 9, 2013
Date of Patent:
February 4, 2020
Assignees:
UNIVERSITY OF THE RYUNKYUS, OKINAWA RESEARCH CENTER CO., LTD.
Abstract: An objective of the present invention is to provide a method for producing a nepodin-containing extract containing a high concentration of nepodin with less contaminants present therein thereby being able to be readily carried out on an industrial scale, when compared to the conventional techniques.
Type:
Grant
Filed:
February 21, 2017
Date of Patent:
December 10, 2019
Assignees:
UNIVERSITY OF THE RYUKYUS, OKINAWA RESEARCH CENTER CO., LTD.
Abstract: An objective of the present invention is to provide a method for producing a nepodin-containing extract containing a high concentration of nepodin with less contaminants present therein thereby being able to be readily carried out on an industrial scale, when compared to the conventional techniques.
Type:
Application
Filed:
February 21, 2017
Publication date:
April 11, 2019
Applicants:
OKINAWA RESEARCH CENTER CO., LTD., UNIVERSITY OF THE RYUKYUS
Abstract: The present invention relates to a pharmaceutical composition comprising a Magnolia flower extract, a fraction thereof or the compound represented by formula 1 or formula 2 below as an active ingredient. Particularly, fargesin isolated from the said Magnolia flower extract and the fraction thereof can promote not only the growth of dental root but also the growth of periodontal tissue by forming alveolar bone in around teeth to inhibit periodontitis. Therefore, not only the fargesin but also the Magnolia flower extract comprising fargesin and the fraction thereof can be effectively used as an active ingredient for a pharmaceutical composition for promoting the growth of dental root and periodontal tissue and for preventing and treating periodontitis.
Abstract: The object of the invention is to provide a method of manufacturing a fraction containing nobiletin and tangeretin at high concentrations, which is excellent in terms of safety, economic efficiency, and the potential for industrialization.
Type:
Application
Filed:
August 9, 2013
Publication date:
October 8, 2015
Applicants:
OKINAWA RESEARCH CENTER CO., LTD., UNIVERSITY OF THE RYUKYUS